DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpA and zgc:162184

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001082852.1	Gene:	zgc:162184 / 559822	ZFINID:	ZDB-GENE-070424-83	Length:	514	Species:	Danio rerio

Alignment Length:	526	Identity:	207/526 - (39%)
Similarity:	316/526 - (60%)	Gaps:	30/526 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 QSNSTLYYGNLGEKSSSLG-PYSEV-QDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDR-- 124
            |.|..:....:.||:.:|. |.:.: |||:.:|.||:.:...|.|..||..:.|:.    |:.
Zfish     5 QVNKPMSEMTMKEKAGTLDVPLNFLGQDYQELLKSCITNRMRFVDDRFPPDSSSID----PNNKL 65

  Fly   125 -----HIEWLRPHEIAENPQFFVEGYSRFDVQQGE-LGDCWLLAATANLTQESNLFFRVIPAEQS 183
                 .|:||||.:|..:|||.|:|.||||..||. ||:||.||:...||.:.::.::|:|..||
Zfish    66 GLDMSQIQWLRPSKIVADPQFIVKGVSRFDYSQGSFLGNCWFLASVGTLTFQKDVLYQVMPEGQS 130

  Fly   184 FEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEAL 248
            |.::||||||||||::|||:||:|||:|||..|:|:::||...||||.|||||||||:.|||..:
Zfish   131 FGKDYAGIFHFRFWRFGKWIDVVIDDKLPTIKGDLIFVHSKTSNEFWPALLEKAYAKVCGSYSDM 195

  Fly   249 KGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRG 313
            ..|...||:.|||||:...::|::.|.:|::::.:||:..::|.|...|.......|.|.|:::|
Zfish   196 DAGVVSEALLDFTGGIHVRFELEKPPLDLWSLMDRAAKCKALMACGTYPGKTSANTELPNGIVQG 260

  Fly   314 HAYSITKVCLIDIVTPNRQG-KIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFD 377
            ||||:|.:..:     ..|| .:.::|:.|||| :.||.|.|.|.|..|..:.|.::.:. .:..
Zfish   261 HAYSVTGIFKV-----TWQGAPVRLVRVLNPWG-KREWTGAWCDKSSMWNKVSESERTKC-WSLA 318

  Fly   378 RDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDT 442
            .|||||||.:||..:|:.|:||..:||.|    .||.|..|:...|.|.|..|.|||||.|..::
Zfish   319 NDGEFWMSMEDFSKNFEEVDICCFTPDFL----DNSSKCSWKTVRYNGSWEAGKTAGGCLNHKES 379

  Fly   443 FWHNPQYIITLVDPDEEDEEGQC--TVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRP 505
            ||.|||:.:|:...|||....||  .|:|:|:|.:....|:....| :|||.:::: ..|:::..
Zfish   380 FWTNPQFRVTIEKLDEECSSSQCPENVLVSLLQIHEDRYRSRVKNC-SIGFCVFAI-PPEMKDER 442

  Fly   506 QGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEEN 570
            ...:||..:.:|..|..|:|.|.|...|||.||.|||||:||.|||..:|::.:||:::::.:..
Zfish   443 FPASFFSRRRTVAESEAFVNARHVMKFFKLEPGEYLIVPTTFKPNECAKFMLSIFSKSESHRKSR 507

  Fly   571 DDHVGY 576
            ...:.|
Zfish   508 KPEMTY 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	129/304 (42%)
		Calpain_III	418..565	CDD:279416	58/148 (39%)
		EFh	719..765	CDD:238008
zgc:162184	NP_001082852.1	Peptidase_C2	47..340	CDD:279042	128/303 (42%)
zgc:162184	NP_001082852.1	Calpain_III	355..502	CDD:279416	58/148 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920