Protein Alignment CalpA and adgb

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_009293055.1
• Gene: adgb / 555435
• ZFINID: ZDB-GENE-041001-205
• Length: 1473
• Species: Danio rerio
• Alignment Length: 713
• Identity: 129/713 - (18%)
• Similarity: 226/713 - (31%)
• Gaps: 223/713 - (31%)

  Fly    56 MRVQPLQSQSNSTLYYGNLG-----EKSSSLG-PYSEVQDYETIL------NSCLASGSLFEDPL 108
            |...|.:..|.|:|...:.|     |.||.:| ..|.|:..::::      |....:...::.|.
Zfish     1 MSKTPKKKASASSLVASSPGHSPKKEASSLVGASESPVESKKSLISLWPEWNDTDVNAEKWDAPK 65

  Fly   109 FPASNESLQFSRRPDRHIE---------WLRPHE-IAENPQFFVEGYSRFDVQQGE--------- 154
            .|..::...   .|:..:|         |.||.| |.:.....||....||:....
Zfish    66 TPKDSKLFD---DPEGKVELPSSLRIHTWKRPSEFILKKIPVVVENADTFDLTSANEHLFSSELM 127

  Fly   155 ---LGDCWLLAATANLTQESNLFFRVIPA-----EQSFEENYAGIFHFRFWQ-YGK--------- 201
               :.:|.:|....|..::..:....:|.     |..:....||..|...:. |||
Zfish   128 RWIISECHILWKVCNTREDKVVSTETVPTLWKPWEHIYSLCKAGKDHMPLYNTYGKYVIKLYWLG 192

  Fly   202 -WVDVIIDDRLP-TYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCE-----AMED 259
             |..:.:||.|| ..:..|:...:|.::|.|..||.|...|: .|.:....||..|     .:..
Zfish   193 SWRKITVDDMLPFDKDNNLLLPATTNQSELWPMLLAKGILKV-ASTDTPVSGSGREFGEFTIIHC 256

  Fly   260 FTGGVSEWYDLKE-APGNLFTILQ------KAAERNSMMGCSIEPDPNVTEAET----------- 306
            .||.:.|...||. ..|.::..|:      :..|.:|....:| .|.||...::
Zfish   257 LTGWIPEMIPLKSWYTGKIWDFLRDNVAQFQLEEESSEEKITI-TDSNVNNVQSKSPKSRATGSV 320

  Fly   307 PQ---------------------------------GLIRGHAYSITKVCLID--IVTPNRQGKIP 336
            ||                                 ||.:..::.:...|..|  :|.|.:...:|
Zfish   321 PQIVVCASYQPLHLMEKRTSMLTRMADSSESLRQYGLSQLFSHPVLLTCTRDCPLVAPPKTPPLP 385

  Fly   337 MIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNL 401
            ..::..|   ..:.|  .:|...|    |..||.|             .|.:..:.|...::..:
Zfish   386 QWKLIRP---RKQTN--ITDEPKE----PPVQKPE-------------QFIEVSSPFINFKLMTM 428

  Fly   402 SPDSLTEDQQNSGKRKWEMSMYEGEWT----------PGVTAGGCRNFLDTFWHNPQYIITLVDP 456
            |    ..|.::.|.:|   .||....|          ..:.....:|..:|...|....:...|.
Zfish   429 S----AHDMEHGGLKK---RMYNSNLTSFSEMEDTEDEHIQNDNIQNSTNTLQTNENTQVPAEDK 486

  Fly   457 DEE-----DEEGQCTVIVALMQKNRRSKRNM--GMECLTIGFAIYSLNDRELENRP--------- 505
            .::     |.||..:......:.:|:.|..:  |.|.   ...:....|....|:|
Zfish   487 KKDNSIANDTEGVESTAAPDKETDRKDKEKVQTGKES---SAGLLQSQDALASNKPLLLKTWVDL 548

  Fly   506 -------QGLNFF--------RYKSSVGRSPHFINTREVCARFKLPPGHYLI--------VPSTF 547
                   |.|..|        ::|:|     ||.|:  :.:|.......|.:        :|...
Zfish   549 HNFTKCFQTLLIFHKPNMYPHQFKTS-----HFTNS--ISSRLSAAALSYTVASTHSVAALPKQS 606

  Fly   548 D-------PNEEGEFIIRVFSETQNNMEENDDHVGYGG-----------KADTITPGFPTPKP 592
            |       .:.:|:....:|::   |:...:..:|:..           |..:..||..|.||
Zfish   607 DLTGNIHTQSADGKGTYFLFAD---NLLSTEIVIGFSALVHWGESVEERKESSTRPGSLTAKP 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	73/392 (19%)
		Calpain_III	416..569	CDD:238132	33/208 (16%)
		EFh_PEF_CalpA_B	600..843	CDD:320071
		EF-hand motif	600..627	CDD:320071
		EF-hand motif	717..747	CDD:320071
		EF-hand motif	748..778	CDD:320071
		EF-hand motif	784..812	CDD:320071
		EF-hand motif	813..843	CDD:320071
adgb	XP_009293055.1	CysPc	72..>269	CDD:469591	43/200 (22%)
		Adgb_C_mid-like	712..1114	CDD:412094
		globin helix C	713..719	CDD:412094
		globin helix D	728..733	CDD:412094
		globin helix E	735..755	CDD:412094
		globin helix F	766..774	CDD:412094
		globin helix G	780..798	CDD:412094
		globin helix H	807..830	CDD:412094
		IQ motif	851..869	CDD:412094
		globin helix A	878..894	CDD:412094
		globin helix B	895..908	CDD:412094
		CR6_interact	<1387..1447	CDD:431088