DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and PEF1

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_036524.1	Gene:	PEF1 / 553115	HGNCID:	30009	Length:	284	Species:	Homo sapiens

Alignment Length:	332	Identity:	77/332 - (23%)
Similarity:	118/332 - (35%)	Gaps:	100/332 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   536 PPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKEGL 600
            |||.|...|    ||..|::        .:.:....   ||||.|    ||.|...|......|
Human    21 PPGSYYPGP----PNSGGQY--------GSGLPPGG---GYGGPA----PGGPYGPPAGGGPYG- 65

  Fly   601 RRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDD-GAGACGLL 664
                                    |      |.|.:|           .:..||.. |..|.|
Human    66 ------------------------H------PNPGMF-----------PSGTPGGPYGGAAPG-- 87

  Fly   665 SLICGPFLKGTPFE---EQLGMNDQSNKRLIGDNPADGGPVTAN--AIVDETH------------ 712
                ||:.:..|..   :|.|:..|      |..|.:..|...:  ..||..|
Human    88 ----GPYGQPPPSSYGAQQPGLYGQ------GGAPPNVDPEAYSWFQSVDSDHSGYISMKELKQA 142

  Fly   713 -------GFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLR 770
                   .|:.:.|..|:.|.|..|||::....|..|...|.:||.:|:.||.:.:|.:|..:|:
Human   143 LVNCNWSSFNDETCLMMINMFDKTKSGRIDVYGFSALWKFIQQWKNLFQQYDRDRSGSISYTELQ 207

  Fly   771 EALNSAGYHLNNRVLNVLGHRYGSRDGKIA--FDDFIMCAVKIKTYIDIFKERDTEKNETATFTL 833
            :||:..||:|:.:...:|..||..|....|  .|.||....:::...:.|:|:||........:.
Human   208 QALSQMGYNLSPQFTQLLVSRYCPRSANPAMQLDRFIQVCTQLQVLTEAFREKDTAVQGNIRLSF 272

  Fly   834 EEWIERT 840
            |:::..|
Human   273 EDFVTMT 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042
		Calpain_III	418..565	CDD:279416	8/28 (29%)
		EFh	719..765	CDD:238008	16/45 (36%)
PEF1	NP_036524.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..111		34/162 (21%)
		9 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-P. /evidence=ECO:0000305	21..109		33/160 (21%)
		EFh_PEF_peflin	118..283	CDD:320059	41/162 (25%)
		EF-hand motif	118..147	CDD:320059	3/28 (11%)
		EF-hand motif	155..184	CDD:320059	9/28 (32%)
		EF-hand motif	185..215	CDD:320059	10/29 (34%)
		Required for interaction with PDCD6. /evidence=ECO:0000269\|PubMed:11883899	204..284		20/76 (26%)
		EF-hand motif	221..251	CDD:320059	8/29 (28%)
		EF-hand motif	252..283	CDD:320059	6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910