DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and capn1

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001013632.1	Gene:	capn1 / 541455	XenbaseID:	XB-GENE-990196	Length:	713	Species:	Xenopus tropicalis

Alignment Length:	812	Identity:	321/812 - (39%)
Similarity:	454/812 - (55%)	Gaps:	145/812 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LQSQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSR-RPDR 124
            ||.|.:..|..|........||     |||:.||:.||.:.:||:|..||.|..||.|.. .|:.
Frog    18 LQKQRDQELGVGKHENAVKFLG-----QDYDRILHECLQNRTLFKDDTFPPSAYSLGFKELGPNS 77

  Fly   125 H----IEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFE 185
            .    ::|:||.::..||||.|:|.:|.|:.||.|||||||||.|:||....:..||:|..|||:
Frog    78 SKTYGVKWVRPSQLVSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTILHRVVPHGQSFQ 142

  Fly   186 ENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKG 250
            :||||:|||:.||:|:||||:|||.||..:|:|:::||...||||||||||||||.:|.||||.|
Frog   143 DNYAGVFHFQLWQFGEWVDVVIDDYLPVKDGKLVFVHSASGNEFWSALLEKAYAKANGCYEALSG 207

  Fly   251 GSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVT-----EAETPQGL 310
            |||.|..|||||||:|||::|:||.:||:|:.||.||.|:|||||:    :|     ||.|.:.|
Frog   208 GSTSEGFEDFTGGVTEWYEMKKAPKDLFSIIMKAVERGSLMGCSID----ITSATDMEAVTFKKL 268

  Fly   311 IRGHAYSITKVCLIDIVTPNRQGKI-PMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGL 374
            ::|||||:|....|     |.:|:. .:|||||||| |.||.|.|||:|.||..:......::.:
Frog   269 VKGHAYSVTGAKEI-----NFRGRSQKLIRMRNPWG-EVEWTGAWSDNSSEWNSVDAADSQDLRI 327

  Fly   375 TFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNF 439
            ..: ||||||:|:|||..|.|:|||||:||:||..:.    |||..:::.|.|..|.||||||||
Frog   328 KME-DGEFWMAFEDFLREFSRLEICNLTPDALTARKY----RKWNTTVFNGNWRKGSTAGGCRNF 387

  Fly   440 LDTFWHNPQYIITLVDPDEEDEEGQ---CTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDREL 501
            ..|||.|||:.|.|.:.|::|:.|.   ||.::|||||::|.:|..|.:..|||||:|     |:
Frog   388 PATFWINPQFKIKLDEEDDDDDFGSEKGCTFLLALMQKDKRKERRFGKDMETIGFAVY-----EV 447

  Fly   502 ENRPQG-------LNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRV 559
            .::..|       .:||...:|..||..|||.|||..|.|||||.|::|||||:||.||:|::|.
Frog   448 PSQFHGQSGVHLKRDFFLQNASRARSEQFINLREVSTRHKLPPGEYIVVPSTFEPNVEGDFVVRF 512

  Fly   560 FSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQK--------EGLRRLFDSIAGKDMEVDW 616
            |||.::...|.||               |....:.|::        :|.:.||..:||.|.|:..
Frog   513 FSENKHGSVEMDD---------------PLSADLPPEEVLSEAEIDQGFKNLFKQLAGADNEISA 562

  Fly   617 MELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQL 681
            .||:.||:..|
Frog   563 TELQSILNKIM------------------------------------------------------ 573

  Fly   682 GMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEI 746
                ..:|.|                  .|.|||.:.|||||.::|.|.:||||..||..|.::|
Frog   574 ----SKHKDL------------------RTSGFSLESCRSMVNLMDKDGNGKLGLVEFNVLWNKI 616

  Fly   747 AKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKI 811
            ..:..:|:.:|::.:|.:|.:::|.|:.|||:.|.|.:..::..||...|..:.||.|..|.:::
Frog   617 KNYLTVFRKFDMDKSGSMSAYEMRLAVESAGFKLTNSLHQLIITRYSEPDMAVNFDSFTCCLIRL 681

  Fly   812 KTYIDIFKERDTEKNETATFTLEEWIERTIYS 843
            :|....|:..||||.....|.:.:|::.|:::
Frog   682 ETMFRFFQGMDTEKKGVIHFDIFKWLQMTMFA 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	159/306 (52%)
		Calpain_III	418..565	CDD:279416	73/156 (47%)
		EFh	719..765	CDD:238008	18/45 (40%)
capn1	NP_001013632.1	Peptidase_C2	56..352	CDD:366222	159/306 (52%)
		Calpain_III	373..518	CDD:366446	72/149 (48%)
		EFh_PEF_CAPN1	545..713	CDD:320073	60/243 (25%)
		EF-hand motif	545..573	CDD:320073	11/27 (41%)
		EF-hand motif	588..617	CDD:320073	14/28 (50%)
		EF-hand motif	618..648	CDD:320073	8/29 (28%)
		EF-hand motif	654..682	CDD:320073	7/27 (26%)
		EF-hand motif	684..713	CDD:320073	8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I950
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	643	1.000	Inparanoid score	I801
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm9483
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060