DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and capn2l

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001003485.1	Gene:	capn2l / 445091	ZFINID:	ZDB-GENE-050417-341	Length:	700	Species:	Danio rerio

Alignment Length:	760	Identity:	324/760 - (42%)
Similarity:	443/760 - (58%)	Gaps:	104/760 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQFSR-RPD----RHIEWLRPHEIAENPQFFVEGYSR 147
            ||||.:...||.||.||.|.:|.|:..:|.|.. .|:    |.:|||||.::..||.|...|.:|
Zfish    30 QDYEALKRECLESGRLFHDDMFEANVSALGFKELGPNSSKVRGVEWLRPKQLTSNPTFISGGATR 94

  Fly   148 FDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLP 212
            .|:.||.|||||||||.|:||...::|.||:||.|||:.:|||||||:|||:|:||||:||||||
Zfish    95 TDICQGALGDCWLLAAIASLTLNQDVFARVVPAGQSFDGDYAGIFHFQFWQFGEWVDVVIDDRLP 159

  Fly   213 TYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNL 277
            ..||||:::||.|.:||||||||||||||:|.||||.||:|.|..||||||::|.::|.:|..||
Zfish   160 ARNGELLFVHSAEGSEFWSALLEKAYAKLNGCYEALSGGTTTEGFEDFTGGIAEVHELAKAGPNL 224

  Fly   278 FTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMR 341
            |..:|||....|::||||: ...:.:||.|.|.|::|||||:|....::.    |.....:||:|
Zfish   225 FKTIQKALSWGSLLGCSIDITSSSDSEAITSQKLVKGHAYSVTGAEEVEY----RGDLTKLIRIR 285

  Fly   342 NPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSL 406
            |||| :.||.|||||.|.|||.|.:..:..:....: ||||||||.||:.|:.|||||||:||:|
Zfish   286 NPWG-QVEWTGPWSDGSSEWRQISDNDRERLSSKAE-DGEFWMSFSDFMRHYSRVEICNLTPDAL 348

  Fly   407 TEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEE--DEEGQCTVIV 469
            |::..|    ||.:|.::|.|..|.|||||||:.::||.|||::|.|.:.|::  |.|..|:.:|
Zfish   349 TDESVN----KWALSKFDGNWRNGSTAGGCRNYPNSFWMNPQFLIKLEEQDDDPTDNEAGCSFVV 409

  Fly   470 ALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGL--NFFRYKSSVGRSPHFINTREVCAR 532
            .|:|||||..|.:|.:..|||||||.:.|:.:..|...|  |||...:|..||..|||.||||:|
Zfish   410 GLIQKNRRKMRKVGEDMNTIGFAIYEVPDQFVGQRNVHLDRNFFVRHASAARSETFINLREVCSR 474

  Fly   533 FKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQK 597
            |.||||.||||||||:||::|:|.:|||||.|...:|.||.|........||.|     .||.:
Zfish   475 FCLPPGEYLIVPSTFEPNKDGDFCVRVFSEKQAEFQELDDPVESKVAEIEITEG-----DIDSR- 533

  Fly   598 EGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACG 662
              .::||..:||.|.|:...||::||                  ||
Zfish   534 --FKKLFGQLAGADCEISAFELQKIL------------------NN------------------- 559

  Fly   663 LLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLD 727
                                                   |.|.....:|.|||.:.||:||.:||
Zfish   560 ---------------------------------------VIAKRKEIKTDGFSLETCRNMVNLLD 585

  Fly   728 ADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRY 792
            .|.:||||..||:.|.::|..:..::...|.:.:|.:|..::|||:..||:.|||.:..:|..||
Zfish   586 KDGTGKLGLLEFKILWTKIELFVDVYSKNDKDQSGTMSSMEMREAVEKAGFSLNNALHQILVARY 650

  Fly   793 GSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWI 837
            ...:..|.||:|:.|.::::.....||..|.:||.|....:.||:
Zfish   651 SESNLTIDFDNFVACLIRLECMFKAFKVLDKDKNGTVELNMIEWL 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	158/301 (52%)
		Calpain_III	418..565	CDD:279416	78/150 (52%)
		EFh	719..765	CDD:238008	17/45 (38%)
capn2l	NP_001003485.1	Peptidase_C2	46..342	CDD:279042	158/301 (52%)
		Calpain_III	356..507	CDD:279416	78/150 (52%)
		EFh	577..631	CDD:298682	20/53 (38%)
		FRQ1	604..>695	CDD:227455	27/90 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I921
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	656	1.000	Inparanoid score	I755
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm6388
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.870