DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and Capn11

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001002806.2	Gene:	Capn11 / 408218	RGDID:	1302946	Length:	715	Species:	Rattus norvegicus

Alignment Length:	797	Identity:	299/797 - (37%)
Similarity:	443/797 - (55%)	Gaps:	137/797 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 KSSSLGPYSEV-----QDYETILNSCLASGSLFEDPLFPASNESLQFSR-----RPDRHIEWLRP 131
            |...:|.|...     |::|.:..|||..|.|||||.|||..:|:.|..     :...::.|.||
  Rat    24 KDKGVGQYQNAYNYKNQNFEDLRASCLKMGELFEDPFFPAEPQSIGFKELGPKSQEVHNVYWQRP 88

  Fly   132 HEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRF 196
            .:|..||||....:|..|:.||.|||||||||..:||....|.|||:|..|||::||||||||:.
  Rat    89 KDIIHNPQFITNDFSPTDICQGILGDCWLLAAIGSLTTSPKLLFRVVPRSQSFKKNYAGIFHFQL 153

  Fly   197 WQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFT 261
            ||:|.|::|::||||||.|.:|:::|::.:.|||.||||||||||:||||||.||||.|.:||||
  Rat   154 WQFGHWLNVVVDDRLPTKNNKLVFVHASHRQEFWGALLEKAYAKLNGSYEALTGGSTMEGLEDFT 218

  Fly   262 GGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITKVCLID 325
            ||:::...|:..|.||..:|:||.|::|:|||||| .:.:..|......|::||||:||.  |.|
  Rat   219 GGMAQCIRLQNPPHNLLRLLRKALEKSSLMGCSIEATNSDDVEKMAHNMLVKGHAYAITG--LQD 281

  Fly   326 IVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFL 390
            :.  .|.....:||::|||| ..||||.|||.:.||..:..|.:.:: |....|||||||::||:
  Rat   282 VY--YRDKLETLIRIQNPWG-RIEWNGAWSDKAKEWEEVMPEVQMQL-LHKKEDGEFWMSYEDFM 342

  Fly   391 NHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLV- 454
            ::|..:|||||:||:|:....   |..|..:.:||.|..|.|||||||:.:|||.|||:.|:|.
  Rat   343 SNFTLLEICNLTPDALSSWDY---KSCWHTTFFEGSWRRGSTAGGCRNYPETFWSNPQFRISLPE 404

  Fly   455 --DPDEEDEEGQ--CTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLN-----F 510
              ||::..::.:  ||.:|||||||.|..|. |.:.|||||.::|: .:|.:|. |.::     |
  Rat   405 TDDPEDSSDKSEMVCTCLVALMQKNWRHARE-GPQLLTIGFVVFSV-PKEFQNL-QDIHLKKDFF 466

  Fly   511 FRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQ---------NN 566
            .:|:.. |.|..|.|||||.:..:||||.|:|:||||:|:::.:|::|||:|..         |.
  Rat   467 MKYRDH-GFSEIFTNTREVNSHLRLPPGEYVIIPSTFEPHKDADFLLRVFTEKHSETWLLDEVNM 530

  Fly   567 MEENDDHVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDL 631
            :|:..:        :|||........::        ||:::|.:|.:||..:|:::|
  Rat   531 LEQLQE--------ETITDADLDQNSVE--------LFETLANRDSQVDMYDLQKLL-------- 571

  Fly   632 PKPVVFNRFSNNM-AFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDN 695
                  |:.|:.. :|:::
  Rat   572 ------NKMSSKFKSFKSK---------------------------------------------- 584

  Fly   696 PADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVEN 760
                             |||.||||.||.::|.|.|||||..||..|..:|.||..|||..|.:.
  Rat   585 -----------------GFSLDVCRRMVNLMDKDDSGKLGLHEFHILWKKIKKWMEIFKECDQDR 632

  Fly   761 TGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEK 825
            :|.::.:::|.|:..||..:||||..|:..||...:..:.||:||.|.:::|.....|...||:|
  Rat   633 SGNLNSYEMRLAIEKAGIRMNNRVTEVVVARYADANMIVDFDNFINCFLRLKAMFAFFLSMDTKK 697

  Fly   826 NETATFTLEEWIERTIY 842
            ..:....:.:|:..|::
  Rat   698 TGSICLNINQWLHITMW 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	147/301 (49%)
		Calpain_III	418..565	CDD:279416	69/165 (42%)
		EFh	719..765	CDD:238008	22/45 (49%)
Capn11	NP_001002806.2	Peptidase_C2	56..352	CDD:279042	147/301 (49%)
		Calpain_III	367..520	CDD:279416	69/156 (44%)
		Linker. /evidence=ECO:0000250\|UniProtKB:Q9UMQ6	528..543		5/22 (23%)
		Domain IV. /evidence=ECO:0000250\|UniProtKB:Q9UMQ6	544..714		61/254 (24%)
		EFh	591..641	CDD:238008	22/49 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I6051
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48339
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.830