DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and CAPN8

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_001137434.1 Gene:CAPN8 / 388743 HGNCID:1485 Length:703 Species:Homo sapiens


Alignment Length:797 Identity:323/797 - (40%)
Similarity:451/797 - (56%) Gaps:132/797 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 QPLQSQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQF----- 118
            |.|.|..|:..|.|               ||::|:...||.||.||:||.|||...:|.:     
Human    16 QGLGSNQNALKYLG---------------QDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGP 65

  Fly   119 SRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQS 183
            .....:.|.|.||.|:..:|||.|.|.:|.|:.||.|||||||||.|:||....|.:||:|.:|.
Human    66 GSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQD 130

  Fly   184 FEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEAL 248
            |:|||||||||:|||||:||:|:|||||||.||:|:::||.:.|||||||||||||||:|.||||
Human   131 FQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEAL 195

  Fly   249 KGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAE--TPQGLI 311
            .||||.|..||||||:||:||||:.|.||:.|::||....|::||||:.. :..|||  |.|.|:
Human   196 AGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVS-SAAEAEAITSQKLV 259

  Fly   312 RGHAYSITKVCLIDIVTPNRQGKIP--MIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGL 374
            :.||||:|.|..:     |.||. |  :||:||||| |.||:|.|||.:|||.:|...:|.|:..
Human   260 KSHAYSVTGVEEV-----NFQGH-PEKLIRLRNPWG-EVEWSGAWSDDAPEWNHIDPRRKEELDK 317

  Fly   375 TFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNF 439
            ..: |||||||..||:..|.|:||||||||||:.::.:    ||.:.::.|.||.|.|||||:|:
Human   318 KVE-DGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVH----KWNLVLFNGHWTRGSTAGGCQNY 377

  Fly   440 LDTFWHNPQYIITL--VDPDEEDEEGQ--CTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRE 500
            ..|:|.|||:.|.|  ||.|:|:..|:  |||::.|||||||.::.:|...|:||:|:|.: .:|
Human   378 PATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQV-PKE 441

  Fly   501 LENRPQ---GLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSE 562
            ||:...   |.:||.......|:..::|.|||..|.:||||.||:|||||:|.::|||.:|||||
Human   442 LESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSE 506

  Fly   563 TQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDH-- 625
            .:....|..|.|..       .|..|.|..:|.:.:..||||:.:||||.|:....||.:|:.  
Human   507 KKAQALEIGDVVAG-------NPYEPHPSEVDQEDDQFRRLFEKLAGKDSEITANALKILLNEAF 564

  Fly   626 SMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKR 690
            |.|.|:       :|.                                                 
Human   565 SKRTDI-------KFD------------------------------------------------- 573

  Fly   691 LIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKV 755
                                  ||:.:.||.|:::||::.:|.||..||:||..:|.|:..|:..
Human   574 ----------------------GFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWE 616

  Fly   756 YDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKE 820
            .|..::|.:...::|.||..||:.||::|...:..||......|.||.|:.|.::::|...:|..
Human   617 TDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSL 681

  Fly   821 RDTEKNETATFTLEEWI 837
            .|.:|:.....:|.||:
Human   682 LDEDKDGMVQLSLAEWL 698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 165/304 (54%)
Calpain_III 416..569 CDD:238132 72/159 (45%)
EFh_PEF_CalpA_B 600..843 CDD:320071 57/240 (24%)
EF-hand motif 600..627 CDD:320071 12/28 (43%)
EF-hand motif 717..747 CDD:320071 12/29 (41%)
EF-hand motif 748..778 CDD:320071 8/29 (28%)
EF-hand motif 784..812 CDD:320071 8/27 (30%)
EF-hand motif 813..843 CDD:320071 7/25 (28%)
CAPN8NP_001137434.1 Peptidase_C2 46..342 CDD:459889 165/304 (54%)
Calpain_III 354..514 CDD:238132 72/164 (44%)
Domain III 356..379 11/22 (50%)
EFh_PEF_CAPN8 536..703 CDD:320066 57/241 (24%)
EF-hand motif 536..564 CDD:320066 12/27 (44%)
EF-hand motif 578..608 CDD:320066 12/29 (41%)
EF-hand motif 609..639 CDD:320066 8/29 (28%)
EF-hand motif 645..673 CDD:320066 8/27 (30%)
EF-hand motif 674..703 CDD:320066 7/25 (28%)

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