DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpA and clpr-2

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001309563.1	Gene:	clpr-2 / 3565584	WormBaseID:	WBGene00023410	Length:	502	Species:	Caenorhabditis elegans

Alignment Length:	231	Identity:	54/231 - (23%)
Similarity:	90/231 - (38%)	Gaps:	42/231 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 GIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTC 254
            ||...|....|:|..:.||..:|:.:..........:.:.|:||::||:|||.|||..|.||...
Worm     4 GIAQIRLLINGEWKVIKIDFHVPSSSASYEIFTPMVRKQAWAALIQKAFAKLGGSYAKLHGGFAD 68

  Fly   255 EAMEDFTGGVSEWYDLKE--APGNLFT-ILQKAAERNSMMGCSIEPDPNVTEAE--TPQGLIRGH 314
            .|....||..:..|.|.:  :..:::. ||.....:..:..||...:....|.:  ....:...|
Worm    69 IAFLQLTGSFTSTYYLNKLSSDNDIWDFILSMQKSKFLVTACSTYCEEGSEEWDIFLKNQISPNH 133

  Fly   315 AYSI--TKVCLIDIVTPNRQG-KIPMIRMRNPWGNEAEWNGPWSDSSPE-------WRYIPE-EQ 368
            .|||  ||:         .:| ::.:|             |.::.|.|:       |.::|. ::
Worm   134 GYSILDTKI---------HEGHRLVLI-------------GNFTYSLPDQGTGTLKWGHLPRFDE 176

  Fly   369 KAEIGLTFD----RDGEFWMSFQDFLNHFDRVEICN 400
            |...|..||    .....|:........|...|||:
Worm   177 KCLCGNIFDYVLSTTSIHWVDLHILSRFFSCFEICH 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	53/229 (23%)
		Calpain_III	418..565	CDD:279416
		EFh	719..765	CDD:238008
clpr-2	NP_001309563.1	CysPc	<2..212	CDD:381776	53/229 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820