DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and capn8

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001231009.1	Gene:	capn8 / 337730	ZFINID:	ZDB-GENE-050522-279	Length:	701	Species:	Danio rerio

Alignment Length:	775	Identity:	320/775 - (41%)
Similarity:	454/775 - (58%)	Gaps:	107/775 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 LGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRR-----PDRHIEWLRPHE 133
            ||....:: ||:: |||:::...|||..:||.||.|||.::||.::..     ..:.::|.||.|
Zfish    18 LGTNEKAI-PYNK-QDYQSLKQECLAKRALFCDPTFPAESDSLGYNELGRYSFKTKGVQWKRPKE 80

  Fly   134 IAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQ 198
            :..||:|.::|.:|.|:.||.|||||||||.|:||.:..:..||:|:.|||.|:|||||||:|||
Zfish    81 LCSNPEFIMDGANRTDICQGALGDCWLLAAIASLTLDKEILERVVPSGQSFTEDYAGIFHFQFWQ 145

  Fly   199 YGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGG 263
            ||:||||:|||||||.:|:|:::||.|.:|||||||||||||::||||||.||||.|..||||||
Zfish   146 YGEWVDVVIDDRLPTRDGKLLFVHSAEGSEFWSALLEKAYAKVNGSYEALTGGSTTEGFEDFTGG 210

  Fly   264 VSEWYDLKEAPGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITKVCLIDIV 327
            ::|.|:|.:||.|||.::|||....|::||||: .:...|||.|...|::|||||:|....:..
Zfish   211 ITENYELSKAPPNLFKLVQKALALGSLLGCSIDITNSYETEAVTSLKLVKGHAYSVTAAEEVHF- 274

  Fly   328 TPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNH 392
               |...:.::|:||||| |.||.|.|||:|.||..:..|:||::..:.: ||||||::.||:..
Zfish   275 ---RGSLVQLVRIRNPWG-EVEWTGAWSDNSKEWDSVRPEEKAKLDYSAE-DGEFWMAYSDFIQQ 334

  Fly   393 FDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITL--VD 455
            |.::|||||:||:|:.::.|    :|..|.:||.|..|.|||||||...||..|||::|.|  :|
Zfish   335 FSKLEICNLTPDTLSSEEVN----RWSYSQFEGNWRVGSTAGGCRNNPATFCSNPQFMIKLEEID 395

  Fly   456 PDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQ---GLNFFRYKSSV 517
            .|..|....||.:|.|:||:.|..:..|.:..|||||||.:.| ||:.|..   |.:....:.||
Zfish   396 DDPHDGVNGCTFLVGLIQKDGRKDKRFGRDLNTIGFAIYKVPD-ELKGRSNIHLGPDVLLRQRSV 459

  Fly   518 GRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADT 582
            ..|..|||.|||..|||||||.|:|:||||:|:.:|.||:|||:|    .|.:...:|....||
Zfish   460 AGSNTFINLREVSERFKLPPGEYIIIPSTFEPHRKGSFILRVFAE----KEADASQIGTEISAD- 519

  Fly   583 ITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFE 647
            :...|.:.|.|||.   .:|||..:||.|.||..:||::||:         .||..|.||
Zfish   520 VKKHFISEKDIDPH---FKRLFSQVAGSDSEVSVLELQQILN---------TVVSKRKSN----- 567

  Fly   648 TQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETH 712
                                                                         .:|.
Zfish   568 -------------------------------------------------------------VKTD 571

  Fly   713 GFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAG 777
            |||.:.||.::::||.|.|||||..||.||..:|.|:..|||..|.:|:|.:|..::|:|:..||
Zfish   572 GFSLETCRHIISLLDKDGSGKLGLLEFHTLWMKIQKYLEIFKHRDTDNSGTMSSLEMRDAVKEAG 636

  Fly   778 YHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWI 837
            :.|||.||.||..||.:::..|.||.|:.|.::::....:|:..|.:........:.:|:
Zfish   637 FQLNNDVLEVLIARYANQEYAIDFDSFVSCLIRLELLFKMFQLFDKKNTGKIELDILQWL 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	155/301 (51%)
		Calpain_III	418..565	CDD:279416	73/151 (48%)
		EFh	719..765	CDD:238008	22/45 (49%)
capn8	NP_001231009.1	Peptidase_C2	46..342	CDD:279042	155/301 (51%)
		Calpain_III	356..507	CDD:279416	73/155 (47%)
		EFh	578..633	CDD:238008	25/54 (46%)
		EFh	607..691	CDD:298682	28/83 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I921
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	656	1.000	Inparanoid score	I755
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm6388
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.970