DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and Capn12

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_038967508.1	Gene:	Capn12 / 308476	RGDID:	1307341	Length:	766	Species:	Rattus norvegicus

Alignment Length:	773	Identity:	270/773 - (34%)
Similarity:	401/773 - (51%)	Gaps:	147/773 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQFSR-RPD----RHIEWLRPHEIAENPQFFVEGYSR 147
            |:||.|..:||.||.||.||.|||..::|.:.: .||    :.:||.||||....|||..|..||
  Rat    30 QNYEAIRAACLDSGILFRDPCFPAGPDALGYDKLGPDSEKAKGVEWKRPHEFCAEPQFICEDMSR 94

  Fly   148 FDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLP 212
            .||.||.||:||||||.|:||....|.:||:|..|.|::.|||:|||:.||:|:||||::||:||
  Rat    95 TDVCQGSLGNCWLLAAAASLTLYPRLLYRVVPPGQGFQDGYAGVFHFQLWQFGRWVDVVVDDKLP 159

  Fly   213 TYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNL 277
            ..:|:|:::.|.::||||:.||||||||||||||.::||...||..||||||.|...|::....:
  Rat   160 VRDGKLLFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNTPGV 224

  Fly   278 FTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSIT---KVCLIDIVTPNRQG--KIPM 337
            |..|:.|..:.|::|.:...|..  |..|.:||::|||||:|   |:.|         |  |:.:
  Rat   225 FAALRHALAKESLVGATALSDRG--EIRTDEGLVKGHAYSVTGTHKMSL---------GFTKVRL 278

  Fly   338 IRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLS 402
            :|:||||| ..||:||||||.|.|..:|.|.:..: |....||||||..||||.||:.|:||:||
  Rat   279 LRLRNPWG-RVEWSGPWSDSCPRWDMLPSEWRDAL-LVKKEDGEFWMELQDFLTHFNTVQICSLS 341

  Fly   403 PDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEE----DEEG 463
            |:.|.......|   |.:..::|.|..|..:||.:...:.||.|||:.:||::||||    ||||
  Rat   342 PEVLGPSPAGGG---WHIHTFQGRWVRGFNSGGSQPSAENFWTNPQFRLTLLEPDEEEDEDDEEG 403

  Fly   464 -------------------QCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDREL----ENRP 505
                               :|||:::|:|:|||..|..|:..||:||.::.:.:..|    ..|.
  Rat   404 PWGGWGAAGARPARGGRVPKCTVLLSLIQRNRRCLRAKGLTYLTVGFHVFQIPEELLGLWDSPRS 468

  Fly   506 QGL--NFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNME 568
            :.|  ...|...||     |...|:|..|.:|||||||:|||.....:|.:|.:|:|||..:...
  Rat   469 RALLPGLLRADRSV-----FCARRDVSRRCRLPPGHYLVVPSASRVGDEADFTLRIFSERSHTAV 528

  Fly   569 ENDDHVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPK 633
            |.||.:  ....|.:...:   ||::.:   |.:||..:||::.|::.::|:.
  Rat   529 EIDDVI--SADLDALQAPY---KPLELE---LAQLFLELAGEEEELNALQLQT------------ 573

  Fly   634 PVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPAD 698
                                         |:|:...|....|....::|:.
  Rat   574 -----------------------------LISIALEPARNNTRTSGEIGLR-------------- 595

  Fly   699 GGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGR 763
                               .|..:|...  .:..:|....|:.|...:..|:|.|..:|.:.:|.
  Rat   596 -------------------TCEQLVQCF--GRGQRLALYHFQELWGHLLSWQATFDKFDEDASGT 639

  Fly   764 VSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKER 821
            ::..:||.||.:||:||||::...|..||.:...::.|:.|:.||.::..   ||:||
  Rat   640 MNSCELRLALTAAGFHLNNQLTQALTSRYRNSRLRVDFEHFVCCAARLTC---IFRER 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	145/305 (48%)
		Calpain_III	418..565	CDD:279416	61/175 (35%)
		EFh	719..765	CDD:238008	10/45 (22%)
Capn12	XP_038967508.1	Peptidase_C2	46..339	CDD:395523	145/305 (48%)
		Calpain_III	352..530	CDD:238132	62/185 (34%)
		EFh_PEF	567..693	CDD:355382	35/204 (17%)
		EF-hand motif	596..623	CDD:320054	5/28 (18%)
		EF-hand motif	624..654	CDD:320054	10/29 (34%)
		EF-hand motif	660..688	CDD:320054	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920