DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and Capn3

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_058813.2	Gene:	Capn3 / 29155	RGDID:	2269	Length:	821	Species:	Rattus norvegicus

Alignment Length:	850	Identity:	328/850 - (38%)
Similarity:	471/850 - (55%)	Gaps:	157/850 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 GPYSEV------------QDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEI 134
            |.||.:            :.:|.:...||....|:.||.||....||.:|::......|.||.||
  Rat    41 GIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLYLDPEFPPDETSLFYSQKFPIQFVWKRPPEI 105

  Fly   135 AENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQY 199
            .|||:|.:.|.:|.|:.||:|||||.|||.|.||....|.|||||.:|||.|||||||||:||:|
  Rat   106 CENPRFIIGGANRTDICQGDLGDCWFLAAIACLTLNERLLFRVIPHDQSFTENYAGIFHFQFWRY 170

  Fly   200 GKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGV 264
            |.||||:|||.|||||.:|::..|..:|||||||||||||||||||||||||:|.||||||||||
  Rat   171 GDWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235

  Fly   265 SEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAETPQ--------------------- 308
            :|::::|:||.:::.|::||.||.|:|||||:...|:|...:|.
  Rat   236 TEFFEIKDAPSDMYKIMRKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLR 300

  Fly   309 ----------------------------GLIRGHAYSIT--KVCLIDIVTPNRQGKIPMIRMRNP 343
                                        ||::|||||:|  :..|.      :..|:.::|:|||
  Rat   301 DSDLDPRASDDRPSRTIVPVQYETRMACGLVKGHAYSVTGLEEALF------KGEKVKLVRLRNP 359

  Fly   344 WGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTE 408
            || :.||||.|||...:|.::.:::||.:......|||||||:.||:.||.::|||||:.|:|..
  Rat   360 WG-QVEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFVYHFTKLEICNLTADALES 423

  Fly   409 DQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLV--DPDEEDEEGQCTVIVAL 471
            |:..:    |.:|:.||.|..|.:|||||||.||||.||||.:.|:  |.|.:|.|..|:.:|||
  Rat   424 DKLQT----WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVAL 484

  Fly   472 MQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGL--NFFRYKSSVGRSPHFINTREVCARFK 534
            ||||||..|.:|....|||||||.: .:|:....|.|  :||.|.:|..||..:||.|||..||:
  Rat   485 MQKNRRKDRKLGANLFTIGFAIYEV-PKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFR 548

  Fly   535 LPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKEG 599
            |||..|:|||||::|::|||||:|||||.:|..||.::.:.             ..:|:..:|.
  Rat   549 LPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEAENTIS-------------VDRPVKKKKN- 599

  Fly   600 LRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVF--NRFSNNMAFET-QAAGPGDDGAGAC 661
                                             ||::|  :|.::|..... |.|..|.|..
  Rat   600 ---------------------------------KPIIFVSDRANSNKELGVDQEAEEGKDKT--- 628

  Fly   662 GLLSLICGPFLKGTPFEEQLGMNDQSN----------KRLIGDNP---ADGGPVTANAIVD---- 709
                   ||..:|...:.:.|..||.:          :::.||:.   ||......|.:|:
  Rat   629 -------GPDKQGESPQPRPGHTDQESEEQQQFRNIFRQIAGDDMEICADELKNVLNTVVNKHKD 686

  Fly   710 -ETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREAL 773
             :|.||:.:.||||:|::|.|.||:|..:||..|..:|..|:.|||.||.:::|.::.:::|.|:
  Rat   687 LKTQGFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQKIFKHYDTDHSGTINSYEMRNAV 751

  Fly   774 NSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIE 838
            |.||:|||:::.:::..||..:...|.||.||.|.|:::.....|...|.:.:......:.||::
  Rat   752 NDAGFHLNSQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQ 816

  Fly   839 RTIYS 843
            .|:|:
  Rat   817 LTMYA 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	161/346 (47%)
		Calpain_III	418..565	CDD:279416	81/150 (54%)
		EFh	719..765	CDD:238008	21/45 (47%)
Capn3	NP_058813.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Peptidase_C2	77..415	CDD:395523	161/344 (47%)
		Domain III	418..586		87/172 (51%)
		Calpain_III	436..574	CDD:395848	74/138 (54%)
		Calpain_u2	583..653	CDD:406940	18/126 (14%)
		Linker	587..649		17/118 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..651		13/57 (23%)
		Domain IV	650..820		52/169 (31%)
		EFh_PEF_CAPN3	653..821	CDD:320065	52/167 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I918
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	641	1.000	Inparanoid score	I782
OMA	1	1.010	-	-		QHG48339
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm9065
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880