DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and Capn1

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_062025.1	Gene:	Capn1 / 29153	RGDID:	2267	Length:	713	Species:	Rattus norvegicus

Alignment Length:	800	Identity:	327/800 - (40%)
Similarity:	460/800 - (57%)	Gaps:	121/800 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LQSQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSR-RPDR 124
            :|.|.:..|..|........||     ||||.:...||.:|.||:|..||..:.||.|.. .|:.
  Rat    18 VQKQRDKELGLGRHENAIKYLG-----QDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNS 77

  Fly   125 H----IEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFE 185
            .    |:|.||.|:..||||.|:|.:|.|:.||.|||||||||.|:||....:..||:|..|||:
  Rat    78 SKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQ 142

  Fly   186 ENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKG 250
            |.|||||||:.||:|:||||::||.|||.:|:|:::||.:.||||||||||||||::||||||.|
  Rat   143 EGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSG 207

  Fly   251 GSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGH 314
            |.|.||.|||||||:|||||::||.:|:.|:.||.||.|::||||. .|....||.|.:.|:|||
  Rat   208 GCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGH 272

  Fly   315 AYSITKVCLIDIVTPNRQG-KIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDR 378
            |||:|     |......|| ::.:|||||||| |.||.|||||:|.||..:...::.::.:..:
  Rat   273 AYSVT-----DAKQVTYQGQRVNLIRMRNPWG-EVEWKGPWSDNSYEWNKVDPYEREQLRVKME- 330

  Fly   379 DGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTF 443
            ||||||||:||:..|.::|||||:||:|    ::...|.|..:.|||.|..|.|||||||:..||
  Rat   331 DGEFWMSFRDFIREFTKLEICNLTPDAL----KSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATF 391

  Fly   444 WHNPQYIITLVDPDEEDE----EGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENR 504
            |.|||:.|.|.:.|:.|:    |..|:.::|||||:||.:|..|.:..|||||:|.: .|||..:
  Rat   392 WVNPQFKIRLEEVDDADDYDSRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQV-PRELAGQ 455

  Fly   505 PQGL--NFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNM 567
            |..|  :||...:|..:|.||||.|||..|.:||||.|::|||||:||:||:|::|.|||.:...
  Rat   456 PVHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGT 520

  Fly   568 EENDDHVGYGGKADTITPGFPTPKPIDPQK--EGLRRLFDSIAGKDMEVDWMELKRILDH--SMR 628
            :|.||.         |....|..|.:..::  :..:.||..:||.|||:...||:.||:.  |..
  Rat   521 QELDDQ---------IQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKH 576

  Fly   629 DDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIG 693
            .||
  Rat   577 KDL-------------------------------------------------------------- 579

  Fly   694 DNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDV 758
                            .|:|||.:.|||||.::|.|.:||||..||..|.:.|..:..||:.:|:
  Rat   580 ----------------RTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDL 628

  Fly   759 ENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDT 823
            :.:|.:|.:::|.|:.:||:.||.::..::..||...|..:.||:|:.|.|:::|....||..||
  Rat   629 DKSGSMSAYEMRMAIEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKILDT 693

  Fly   824 EKNETATFTLEEWIERTIYS 843
            :.:...||.|.:|::.|:::
  Rat   694 DLDGVVTFDLFKWLQLTMFA 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	162/302 (54%)
		Calpain_III	418..565	CDD:279416	76/152 (50%)
		EFh	719..765	CDD:238008	19/45 (42%)
Capn1	NP_062025.1	Peptidase_C2	56..352	CDD:279042	162/302 (54%)
		Domain III	355..525		81/174 (47%)
		Calpain_III	366..518	CDD:279416	76/152 (50%)
		Linker	526..541		3/23 (13%)
		PTZ00184	537..680	CDD:185504	51/220 (23%)
		Domain IV	542..712		62/247 (25%)
		EF-hand_8	556..609	CDD:290545	25/130 (19%)
		EFh	589..643	CDD:238008	21/53 (40%)
		EFh	622..704	CDD:298682	26/81 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I3983
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	641	1.000	Inparanoid score	I782
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm9065
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870