DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CalpA and Capn1

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_062025.2 Gene:Capn1 / 29153 RGDID:2267 Length:713 Species:Rattus norvegicus


Alignment Length:800 Identity:326/800 - (40%)
Similarity:459/800 - (57%) Gaps:121/800 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 LQSQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSR-RPDR 124
            :|.|.:..|..|........||     ||||.:...||.:|.||:|..||..:.||.|.. .|:.
  Rat    18 VQKQRDKELGLGRHENAIKYLG-----QDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNS 77

  Fly   125 H----IEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFE 185
            .    |:|.||.|:..||||.|:|.:|.|:.||.|||||||||.|:||....:..||:|..|||:
  Rat    78 SKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQ 142

  Fly   186 ENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKG 250
            |.|||||||:.||:|:||||::||.|||.:|:|:::||.:.||||||||||||||::||||||.|
  Rat   143 EGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSG 207

  Fly   251 GSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGH 314
            |.|.||.|||||||:|||||::||.:|:.|:.||.||.|::||||. .|....||.|.:.|:|||
  Rat   208 GCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGH 272

  Fly   315 AYSITKVCLIDIVTPNRQG-KIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDR 378
            |||:|     |......|| ::.:|||||||| |.||.|||||:|.||..:...::.::.:..: 
  Rat   273 AYSVT-----DAKQVTYQGQRVNLIRMRNPWG-EVEWKGPWSDNSYEWNKVDPYEREQLRVKME- 330

  Fly   379 DGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTF 443
            ||||||||:||:..|.::|||||:||:|    ::...|.|..:.|||.|..|.|||||||:..||
  Rat   331 DGEFWMSFRDFIREFTKLEICNLTPDAL----KSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATF 391

  Fly   444 WHNPQYIITLVDPDEEDE----EGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENR 504
            |.|||:.|.|.:.|:.|:    |..|:.::|||||:||.:|..|.:..|||||:|.: .|||..:
  Rat   392 WVNPQFKIRLEEVDDADDYDSRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQV-PRELAGQ 455

  Fly   505 PQGL--NFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNM 567
            |..|  :||...:|..:|.||||.|||..|.:||||.|::|||||:||:||:|::|.|||.:...
  Rat   456 PVHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGT 520

  Fly   568 EENDDHVGYGGKADTITPGFPTPKPIDPQK--EGLRRLFDSIAGKDMEVDWMELKRILDH--SMR 628
            :|.||.         |....|..|.:..::  :..:.||..:||.|||:...||:.||:.  |..
  Rat   521 QELDDQ---------IQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKH 576

  Fly   629 DDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIG 693
            .||                                                              
  Rat   577 KDL-------------------------------------------------------------- 579

  Fly   694 DNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDV 758
                            .|:|||.:.|||||.::|.|.:||||..||..|.:.|..:..||:.:|:
  Rat   580 ----------------RTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDL 628

  Fly   759 ENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDT 823
            :.:|.:|.:::|.|:.:||:.||.::..::...|...|..:.||:|:.|.|:::|....||..||
  Rat   629 DKSGSMSAYEMRMAIEAAGFKLNKKLHELIITHYSEPDLAVDFDNFVCCLVRLETMFRFFKILDT 693

  Fly   824 EKNETATFTLEEWIERTIYS 843
            :.:...||.|.:|::.|:::
  Rat   694 DLDGVVTFDLFKWLQLTMFA 713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 162/302 (54%)
Calpain_III 416..569 CDD:238132 77/158 (49%)
EFh_PEF_CalpA_B 600..843 CDD:320071 61/244 (25%)
EF-hand motif 600..627 CDD:320071 11/28 (39%)
EF-hand motif 717..747 CDD:320071 14/29 (48%)
EF-hand motif 748..778 CDD:320071 8/29 (28%)
EF-hand motif 784..812 CDD:320071 7/27 (26%)
EF-hand motif 813..843 CDD:320071 10/29 (34%)
Capn1NP_062025.2 Peptidase_C2 56..352 CDD:459889 162/302 (54%)
Domain III 355..525 81/174 (47%)
Calpain_III 366..523 CDD:238132 76/157 (48%)
Linker 526..541 3/23 (13%)
Domain IV 542..712 61/247 (25%)
EFh_PEF_CAPN1 545..713 CDD:320073 61/245 (25%)
EF-hand motif 545..573 CDD:320073 11/27 (41%)
EF-hand motif 588..617 CDD:320073 14/28 (50%)
EF-hand motif 618..648 CDD:320073 8/29 (28%)
EF-hand motif 654..682 CDD:320073 7/27 (26%)
EF-hand motif 684..713 CDD:320073 9/28 (32%)

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