DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and clp-9

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001256150.1	Gene:	clp-9 / 266916	WormBaseID:	WBGene00011705	Length:	718	Species:	Caenorhabditis elegans

Alignment Length:	508	Identity:	144/508 - (28%)
Similarity:	211/508 - (41%)	Gaps:	124/508 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 YETILNSCLASGSLFEDPLF---PASNESLQFSR-------RPDRHIEWLRPHEI-----AENPQ 139
            |..|::.|.:|.|.|.|..|   ..|..||||::       .|| .:.||||.::     ..:|.
Worm   123 YSNIISYCKSSNSPFIDDSFLHNKKSIGSLQFTKNGVKRHEEPD-FLNWLRPSQMFTKDGRSSPW 186

  Fly   140 FFVEGYSRFDVQQGEL-GDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWV 203
            ..:......|::||.| |||||::|.|.:.:..::...:||.:|   .::.|::..:....|||.
Worm   187 SVLNNPRPSDIEQGTLVGDCWLMSAMALIAERPDVLDDIIPKKQ---YSHYGVYQIKLCVEGKWE 248

  Fly   204 DVIIDDRLPTYN-GELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEW 267
            .:|:||..|.|: ...:.|....:|:.|..|:|||.||:.|||..|.|.|..:.:...||.....
Worm   249 VIIVDDFFPCYSKTNSIAMAVGRRNQLWVPLIEKAMAKVLGSYSKLHGASLAQGLSMLTGASCVN 313

  Fly   268 YDLKEAPGNLFTI------LQKAAERNSMMGCSIEPDPN-VTEAE-TPQGLIRGHAYSITKVCLI 324
            |:....|.::..:      |..:.|...:|.|......| |.||| ...||:..|||||     :
Worm   314 YNCPPIPSSVDDVDTFWAQLVSSKESGFLMCCHCGAFENVVAEAEFKAMGLLTNHAYSI-----L 373

  Fly   325 DIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDF 389
            |::  ..|| ..::|:||||| :..|||.|||..|.|. |..:||. :....|..|.|||..:||
Worm   374 DVI--YEQG-YRLLRIRNPWG-QFVWNGKWSDGWPGWP-IGMKQKF-LNQRKDETGAFWMDLEDF 432

  Fly   390 LNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTP-GVT--AGGCRNFLDTFWHNP---Q 448
            :..|..|.:|.|..|                      |:. .||  .||         |:.   |
Worm   433 VARFASVTVCKLRMD----------------------WSELRVTHKVGG---------HSDTALQ 466

  Fly   449 YIITLVDPDEEDEEGQCTVIVALMQK---NRRSKRNMGMECL-------TIGFAIYSLNDRELEN 503
            .:||          ..|.|.|...||   |::...|..|.|:       .|| .:..::.|..:|
Worm   467 IVIT----------DTCEVSVTAFQKGAFNKKDNLNDLMVCVHRISGDRRIG-ELIEMSSRISDN 520

  Fly   504 RPQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIV---PSTFDPNEEG 553
                              ||     ....|.|.||.|.||   .|:...|::|
Worm   521 ------------------HF-----TIDEFFLAPGEYQIVCHSQSSLLTNKKG 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	102/320 (32%)
		Calpain_III	418..565	CDD:279416	34/155 (22%)
		EFh	719..765	CDD:238008
clp-9	NP_001256150.1	CysPc	123..453	CDD:128526	111/366 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920