Protein Alignment CalpA and Capn10

DIOPT Version :9

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_035926.2
• Gene: Capn10 / 23830
• MGIID: 1344392
• Length: 666
• Species: Mus musculus
• Alignment Length: 797
• Identity: 222/797 - (27%)
• Similarity: 320/797 - (40%)
• Gaps: 218/797 - (27%)

  Fly   103 LFEDPLFPASNESL---------QFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDC 158
            ||.|..||||:.||         ||  |.|  |.|.||.||...||.|.:......|:||.||||
Mouse    13 LFRDAAFPASDSSLFYNLSTPLAQF--RED--ITWRRPQEICATPQLFPDNPWEGQVKQGLLGDC 73

  Fly   159 WLLAATANLTQESNLFFRVIPAEQS--FEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYM 221
            |.|.|.|.|.:..:|..:|.|..|.  .::.|.|.|..|.||:|.|.:|.||||||...|.|.:.
Mouse    74 WFLCACAALQKSQHLLDQVFPPGQPGWSDQKYQGFFTCRIWQFGHWEEVTIDDRLPCLAGRLCFS 138

  Fly   222 HSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAA- 285
            ....::.||..||||||||:|||||.|..|...:|:.|.||.::|.:.||:        :.||:
Mouse   139 RCQREDVFWLPLLEKAYAKVHGSYEHLWAGQVADALVDLTGSLAERWSLKD--------VTKASG 195

  Fly   286 --ERNS-----------------MMGCSI-EPDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPN 330
              :|.|                 ::.||: .|.....|      |...||:.|:.  |.::.:..
Mouse   196 QQDRPSGGEHRTCRQLLHLKDRCLISCSVLSPRAGARE------LGEFHAFIISD--LQELRSQT 252

  Fly   331 RQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDR 395
            .|| |.::|:.||||... |.|.|.:....|..:...:::|: |...::||||:..::||..||.
Mouse   253 GQG-ILLLRIHNPWGRRC-WQGLWREGGEGWNQVEPAKESEL-LAQLQEGEFWVEEEEFLREFDE 314

  Fly   396 VEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEED 460
            |.|.....::......::.:.........|.|..|.:|||||| ...|..||::.:.|::|.|
Mouse   315 VTIGYPVTEAGHLQSLHTERVLCHTRTLPGAWVTGQSAGGCRN-NSCFPCNPKFWLRLLEPSE-- 376

  Fly   461 EEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLNFFRY---KSSVGR--- 519
                  |.||::|:.||  |.:|......|.:...:|....:.:..||:.::.   |.|:.|
Mouse   377 ------VCVAVLQRPRR--RLVGQTRALAGASPAPVNLPGKDYQAVGLHIWKVEKRKISLPRVLS 433

  Fly   520 SPHFINT------REVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGG 578
            :|....|      ||:..|.:|.||:||.|||||..:..|:|::||||..:.::..    |....
Mouse   434 APPVAGTACHAYDREIHLRCELSPGYYLAVPSTFLKDVPGQFLLRVFSTGKISLSA----VRLAT 494

  Fly   579 KADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNN 643
            |.  .:||...|                 ||     :|
Mouse   495 KG--ASPGTALP-----------------AG-----EW--------------------------- 508

  Fly   644 MAFET-QAAG---PGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTA 704
               || |..|   .|....|:....|..|.|.|   ||..                |...||...
Mouse   509 ---ETVQLQGCWRAGQTAGGSRNFASYPCNPCL---PFSV----------------PEGAGPRYI 551

  Fly   705 NAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQL 769
            . |..:.|      ||     |...:...:||..|:.             ..|.||....| ..|
Mouse   552 R-ITLQQH------CR-----LSDSQLHPIGFHVFQV-------------PADGENQDACS-LLL 590

  Fly   770 REALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKI-------KTYIDIFKERDTEKNE 827
            :|.|           |:.:.|||.....:       :|.:.:       .||:.     |||  .
Mouse   591 QEPL-----------LSCVPHRYAQEVSR-------LCLLSVGNYRIVPSTYLP-----DTE--G 630

  Fly   828 TATFTLEEWIER-TIYS 843
            |.|.|:...|:| :|:|
Mouse   631 TFTVTIATRIDRQSIHS 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	115/327 (35%)
		Calpain_III	418..565	CDD:279416	51/158 (32%)
		EFh	719..765	CDD:238008	9/45 (20%)
Capn10	NP_035926.2	CysPc	8..319	CDD:238004	116/328 (35%)
		Domain III 1	322..488		51/176 (29%)
		calpain_III	338..488	CDD:214786	51/160 (32%)
		Calpain_III	506..647	CDD:238132	48/245 (20%)
		Domain III 2	507..648		48/241 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910