DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpA and clpr-3

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_492904.2	Gene:	clpr-3 / 186784	WormBaseID:	WBGene00010417	Length:	308	Species:	Caenorhabditis elegans

Alignment Length:	228	Identity:	55/228 - (24%)
Similarity:	86/228 - (37%)	Gaps:	48/228 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 GKWVDVIIDDRLPTYNGELMYMHSTEK------NEFWSALLEKAYAKLHGSYEALKGGSTCEAME 258
            |:|..:..|..||      |...|.|:      .:.|:|.:||.:|||.|||::|.......|..
Worm    45 GEWKIIKTDFHLP------MNKQSIEEYAWMIGKQTWAAFIEKGFAKLFGSYKSLSAKPIDVAFR 103

  Fly   259 DFTGGVSEWYDLKEAPGNLFTILQKAAERN--SMMGCSIEPDPNVTEAE---TPQGLIRGHAYSI 318
            ..||..|:.|:|:... |...:.....|.:  ..:.|:.:...:...||   ...|:.:.|||:|
Worm   104 KLTGAFSKNYELRSFK-NCDAVWDMIVEAHLAGFLLCTSKLSLDEESAEYIFNSTGIKQNHAYAI 167

  Fly   319 TKVCLIDIVTPNRQGKIPMIRMRN-----PWGN-EAEWN------GPWSDSSPEWRYIPEEQKAE 371
                |..:|..|.:    ::::.|     .|.. ..|||      ..:|...|...||....
Worm   168 ----LNSVVFENHR----LVQIGNTHACDKWKELHKEWNSLHYFYNKFSSKLPRRPYISHLD--- 221

  Fly   372 IGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPD 404
                   |..|||....:..||..:.:|....|
Worm   222 -------DMSFWMDIDQYCEHFSSLTVCEYRKD 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	53/222 (24%)
		Calpain_III	418..565	CDD:279416
		EFh	719..765	CDD:238008
clpr-3	NP_492904.2	CysPc	<40..242	CDD:381776	53/221 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158982
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740