DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and tra-3

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_502751.1	Gene:	tra-3 / 178385	WormBaseID:	WBGene00006606	Length:	648	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	198/557 - (35%)
Similarity:	295/557 - (52%)	Gaps:	93/557 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIE 127
            ::|..|.::||              |:||.:...|:.....|.|.|||.:|:||...:|....|.
Worm     2 TRSEKTRHFGN--------------QNYEKLRKICIKKKQPFVDTLFPPTNQSLFLEQRQSSDIV 52

  Fly   128 WLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIP----AEQSFEENY 188
            |.||.|:..:|..||||.|..||.||.||:||.::|.:.||....|..:|||    .|.|.:..|
Worm    53 WKRPGELHPDPHLFVEGASPNDVTQGILGNCWFVSACSALTHNFKLLAQVIPDADDQEWSTKHAY 117

  Fly   189 AGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGST 253
            ||||.||||::||||:|:|||.|||.:|:|::..|...|||||||||||:|||:|.||.|.||..
Worm   118 AGIFRFRFWRFGKWVEVVIDDLLPTRDGKLLFARSKTPNEFWSALLEKAFAKLYGCYENLVGGHL 182

  Fly   254 CEAMEDFTGGVSEWYD----LKEAPGN----LFTILQKAAERNSMMGCSIEPDPNVTEAETPQ-- 308
            .:|::|.:|||:|...    ||:.|.:    ||..|:.|.::.:::..:|...   |:.|..:
Worm   183 SDALQDVSGGVAETLHVRKFLKDDPNDTELKLFNDLKTAFDKGALVVAAIAAR---TKEEIEESL 244

  Fly   309 --GLIRGHAYSITKVCLIDIVTPNRQG----------KIPMIRMRNPWGNEAEWNGPWSDSSPEW 361
              ||::||||:::.||.||:..||.:.          |..:||::|||| |.||||.|||.||||
Worm   245 DCGLVKGHAYAVSAVCTIDVTNPNERSFTSFIMGSKRKQNLIRLQNPWG-EKEWNGAWSDDSPEW 308

  Fly   362 RYIPEEQKAEIGL----TFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSM 422
            :.:...|.:.:|:    :...||:|||.::.|:::|..:.:|.|...|:.     |..|.::..:
Worm   309 QNVSASQLSTMGVQPANSDSDDGDFWMPWESFVHYFTDISLCQLFNTSVF-----SFSRSYDEQI 368

  Fly   423 YEGEWT--------PGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSK 479
            ...|||        |...||||.||..||.:|||||..:..|:       |:|:.||:|.:....
Worm   369 VFSEWTTNGKKSGAPDDRAGGCHNFKATFCNNPQYIFDIPSPN-------CSVMFALIQNDPSEG 426

  Fly   480 RNMGMECLTIGFAIYSLNDRELENRPQGLNFFRYKSSVGRSP----HFINTREVCARFK-LPPGH 539
            .......:|||..:     .::||..|      |:......|    .:.:.|.|....: ||.|.
Worm   427 LKKREPFVTIGMHV-----MKVENNRQ------YRVHTAMHPIAISDYASGRSVYLHLQSLPRGR 480

  Fly   540 YLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGY 576
            ||::|:||.|.|:..|::||:|         |:|:.:
Worm   481 YLLIPTTFAPKEQTLFMLRVYS---------DEHIHF 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	136/325 (42%)
		Calpain_III	418..565	CDD:279416	47/159 (30%)
		EFh	719..765	CDD:238008
tra-3	NP_502751.1	CysPc	15..361	CDD:128526	143/354 (40%)
		Calpain_III	362..511	CDD:238132	50/174 (29%)
		C2_Calpain	526..646	CDD:176011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820