DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and clp-7

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_500082.2	Gene:	clp-7 / 176953	WormBaseID:	WBGene00000547	Length:	778	Species:	Caenorhabditis elegans

Alignment Length:	575	Identity:	255/575 - (44%)
Similarity:	353/575 - (61%)	Gaps:	45/575 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GAAKDVVGSVINEI---FIKKEADTKRVLPSIKNMRVQPLQSQSNSTLYYGNL-------GEKSS 79
            |..:.:||::|:..   |......|..::.:|....:..:..|:||....|.:       |:...
Worm   207 GGMESIVGNLISSATHQFFGINPATGAIIGAIAGNIIFQMGGQNNSLSSIGKVVLDNIISGKFKR 271

  Fly    80 SLGPYSE----------VQDYETI-----LNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWL 129
            .:.|::.          .|.::||     ...||....|||||.|||::.||.:..|||..|.|.
Worm   272 DVQPFTPGGGGGPGIGFQQQFQTINFQQERQRCLDQRCLFEDPQFPANDSSLYYKTRPDEPIIWK 336

  Fly   130 RPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHF 194
            ||.||.||||..|...|||||:||.|||||||||.||||....||:||:|.:|||.|||||||||
Worm   337 RPGEIYENPQLIVGEKSRFDVKQGALGDCWLLAAVANLTLRDELFYRVVPPDQSFTENYAGIFHF 401

  Fly   195 RFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMED 259
            :||:||:||||:|||||||.:|.|.||.|.|.|||||||||||||||:|.||.|.||:|.||:||
Worm   402 QFWRYGQWVDVVIDDRLPTVDGRLCYMRSQENNEFWSALLEKAYAKLYGGYENLDGGTTAEALED 466

  Fly   260 FTGGVSEWYDL-KEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSITKVCL 323
            ||||::|::|: |........:|.:..:..|:.||||:.|.||.||:...||:||||||||.:..
Worm   467 FTGGLTEFFDISKGDKSTTLAMLVRGMQMGSLFGCSIDADENVKEAQLTNGLVRGHAYSITAIQT 531

  Fly   324 IDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQD 388
            ::    ...|::|::|:||||||..||||.|||.|.||..:..:|:.::|:.|.:||||||||.|
Worm   532 VN----TYGGQVPLLRIRNPWGNSKEWNGAWSDGSSEWSQVDPQQREQMGVQFAKDGEFWMSFDD 592

  Fly   389 FLNHFDRVEICNLSPDSLTEDQQNSG-------KRKWEMSMYEGEWTPGV-TAGGCRNFLDTFWH 445
            |:.:|.::|.||||.|.:.|..:.:|       |.:|.....:|||.... |||||:| .||:.:
Worm   593 FMTNFTQMECCNLSADVMDEISEMTGVEVHDKQKHQWVEKSEDGEWNSRQGTAGGCQN-NDTYCN 656

  Fly   446 NPQY-IITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLN 509
            |||| ....|..|..:.:|:||||.|::||.||..|..|::.|.|||::|     :.:...|.::
Worm   657 NPQYGTYFQVPMDSVEHDGKCTVIGAVLQKYRRELRTKGLDNLPIGFSVY-----KADGSGQAIH 716

  Fly   510 FFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQ 564
            ....:..:.|:..|||.|||..||::|||.|:|||.|||.:::..|::|:||..:
Worm   717 DVSGQKPIARTKVFINMREVTVRFRVPPGQYVIVPCTFDAHDDASFLLRIFSNAE 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	169/296 (57%)
		Calpain_III	418..565	CDD:279416	59/149 (40%)
		EFh	719..765	CDD:238008
clp-7	NP_500082.2	Peptidase_C2	311..604	CDD:366222	169/296 (57%)
clp-7	NP_500082.2	Calpain_III	627..777	CDD:238132	59/151 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158978
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	578	1.000	Inparanoid score	I553
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm4791
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.900