Protein Alignment CalpA and clp-1

DIOPT Version :9

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_498741.3
• Gene: clp-1 / 176122
• WormBaseID: WBGene00000542
• Length: 780
• Species: Caenorhabditis elegans
• Alignment Length: 590
• Identity: 288/590 - (48%)
• Similarity: 386/590 - (65%)
• Gaps: 56/590 - (9%)

  Fly    25 GAAKDVVGSVINEI---FIKKEADTKRVLPSIKNMRVQPLQSQSNSTLYYGNLGE---------- 76
            |...:|:|::|.|.   |:..:..|.|::.::....:..|..:.||   .||:|:
 Worm   204 GGMVNVIGNLIGEAAHRFLGVDPGTGRIIGAVAGNVIMGLGGKDNS---LGNIGKVILDNIISGK 265

  Fly    77 ------------------------KSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQ 117
                                    ...|..|.:|.||:..:.:.||.|..|||||.|.|::.||.
 Worm   266 FRRDVDPFVRPGPDPDRGGGGSGPSPISPRPTTEPQDFYELRDQCLESKRLFEDPQFLANDSSLF 330

  Fly   118 FSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQ 182
            ||:||.:.:|||||.||...||...||:|||||.||||||||||||.||||.:..||:||:|.:|
 Worm   331 FSKRPPKRVEWLRPGEITREPQLITEGHSRFDVIQGELGDCWLLAAAANLTLKDELFYRVVPPDQ 395

  Fly   183 SFEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEA 247
            ||.|||||||||:||||||||||:|||||||.||||:||||...|||||||||||||||.|||||
 Worm   396 SFTENYAGIFHFQFWQYGKWVDVVIDDRLPTSNGELLYMHSASNNEFWSALLEKAYAKLFGSYEA 460

  Fly   248 LKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIR 312
            ||||:|.||:||.|||::|:.|||..|.||..::.:..|..|:.|||||.||||.||:...||::
 Worm   461 LKGGTTSEALEDMTGGLTEFIDLKNPPRNLMQMMMRGFEMGSLFGCSIEADPNVWEAKMSNGLVK 525

  Fly   313 GHAYSITKVCLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFD 377
            |||||||...::|  .||  |:..::|:|||||||.||||||||:|.|||.:|:..|.::||.||
 Worm   526 GHAYSITGCRIVD--GPN--GQTCILRIRNPWGNEQEWNGPWSDNSREWRSVPDSVKQDMGLKFD 586

  Fly   378 RDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRK----WEMSMYEGEWTPGVTAGGCRN 438
            .||||||||.||:.:|:::|||||.||.:.|..|.:|.:.    |..:.::|.|....|||||||
 Worm   587 HDGEFWMSFDDFMRNFEKMEICNLGPDVMDEVYQMTGVKAAGMVWAANTHDGAWVRNQTAGGCRN 651

  Fly   439 FLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELEN 503
            :::||.:|||:.:.|.|.|.:|::..||||.|::||.||:.:..|::.:.||||:|...:    |
 Worm   652 YINTFANNPQFRVQLTDSDPDDDDELCTVIFAVLQKYRRNLKQDGLDNVPIGFAVYDAGN----N 712

  Fly   504 RPQ-GLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNM 567
            |.: ...||....|..||..|||.||:..||::|||:|::|||||:||||.||::||::   |..
 Worm   713 RGRLSKQFFAANKSAMRSAAFINLREMTGRFRVPPGNYVVVPSTFEPNEEAEFMLRVYT---NGF 774

  Fly   568 EENDD 572
            .|:::
 Worm   775 IESEE 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	190/295 (64%)
		Calpain_III	418..565	CDD:279416	65/147 (44%)
		EFh	719..765	CDD:238008
clp-1	NP_498741.3	Peptidase_C2	317..609	CDD:279042	190/295 (64%)
		Calpain_III	631..772	CDD:279416	65/147 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158976
Domainoid	1	1.000	424	1.000	Domainoid score	I312
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	578	1.000	Inparanoid score	I553
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48339
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm4791
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2435
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.940