DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpA and clp-3

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_493052.3	Gene:	clp-3 / 173089	WormBaseID:	WBGene00000544	Length:	752	Species:	Caenorhabditis elegans

Alignment Length:	591	Identity:	214/591 - (36%)
Similarity:	313/591 - (52%)	Gaps:	70/591 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AGQEFLNAAGE--AAMGAAKDVVGSVINEIFIKKEADTKRVLPSIKNMRVQPLQSQSNSTLYYGN 73
            ||.|..|..||  :.....|.|:.::::..| |:|...           ..||..|   .:|:..
Worm   205 AGNEMFNMGGETNSLSSIGKIVLDNIVSGKF-KRECHV-----------YVPLSCQ---PIYFHE 254

  Fly    74 LGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENP 138
            ..:|                   ||....|||||.|||:|.|:....||..||.|.||.|:..||
Worm   255 ERQK-------------------CLDEKRLFEDPQFPANNSSIYVKVRPKDHIVWKRPGELFANP 300

  Fly   139 QFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWV 203
            :......:.|||:.|.|.:.|.|:..|||:....||:||:|.:|||.|.|||||||:||:||:||
Worm   301 RLIGSDKTHFDVKLGRLENRWFLSGAANLSLRDELFYRVVPPDQSFTEKYAGIFHFQFWRYGEWV 365

  Fly   204 DVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAM----EDFTGGV 264
            ||:|||||||.||.|.||.|...:|||..|||||||||.|:||.|....|.:|:    ..||||:
Worm   366 DVVIDDRLPTVNGTLCYMSSPGGSEFWGPLLEKAYAKLLGTYEHLNDPYTEQALWQASASFTGGL 430

  Fly   265 SEWYDLKEAPG-NLFTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSITKVCLIDIVT 328
            ::|:|:..|.. .:..::.:..:..|::.| :..|.|........|||:|:.|.||.|.|::
Worm   431 TQWFDIFMADEMAVLAMIMRGVQMGSLIVC-LNIDVNEKGVRQKNGLIKGYGYCITGVNLME--- 491

  Fly   329 PNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHF 393
             ....|.|:||:|:||| :.:|.|.:...|..|..:.:|::....:  ..|||||||.:||:..|
Worm   492 -TEWEKAPLIRIRSPWG-KVKWKGDFCYRSHRWFGLDKEKRESFRI--KEDGEFWMSLKDFMVEF 552

  Fly   394 DRVEICNLSPDSLTEDQQ-------NSGKRKWEMSMYEGEWTPGV-TAGGCRNFLDTFWHNPQYI 450
            ..|..||||.|::.|.::       ....::|..:.:||||:..: |||||.:. |||..|.||.
Worm   553 TDVYCCNLSADTMHEVEKMTEVKVMEHQSQQWIQASFEGEWSSRIGTAGGCDDH-DTFCTNLQYE 616

  Fly   451 ITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLNFFRYKS 515
            |.....|..|...:||:|.||.||||......|:|...||..:|.:.....:..|:   ..:.::
Worm   617 IHFRATDSYDSNHKCTIIAALFQKNRDHCVYKGLELFLIGLLVYEMPGPNEKVTPE---MVKSQT 678

  Fly   516 SVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDH-----VG 575
            .:..|..|.::||...||.:|.|||:|||||:||:::|||::|:|:    |::.:..|     :|
Worm   679 PIADSKLFKDSREANIRFTVPLGHYVIVPSTYDPDQDGEFLLRIFT----NVDFDKTHALSNGIG 739

  Fly   576 YGGKAD 581
            ...|:|
Worm   740 LICKSD 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	128/300 (43%)
		Calpain_III	418..565	CDD:279416	56/147 (38%)
		EFh	719..765	CDD:238008
clp-3	NP_493052.3	MDN1	<5..136	CDD:227596
		CysPc	254..559	CDD:238004	132/331 (40%)
		Calpain_III	582..732	CDD:238132	57/157 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158979
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.710