Protein Alignment CalpA and Capn8

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_063128053.1
• Gene: Capn8 / 170808
• RGDID: 620085
• Length: 753
• Species: Rattus norvegicus
• Alignment Length: 801
• Identity: 332/801 - (41%)
• Similarity: 463/801 - (57%)
• Gaps: 144/801 - (17%)

  Fly    61 LQSQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFS----RR 121
            |.|..|:..|.|               ||:||:...||.||.||:||.|||...:|.:.    ..
  Rat    68 LGSNQNAVKYLG---------------QDFETLRKQCLNSGVLFKDPEFPACPSALGYKDLGPGS 117

  Fly   122 PD-RHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFE 185
            || :.|.|.||.|:..||||.|.|.:|.|::||.|||||||||.|:||....|.:||:|.:|||:
  Rat   118 PDTQGIVWKRPTELCPNPQFIVGGATRTDIRQGGLGDCWLLAAIASLTLNEKLLYRVLPRDQSFQ 182

  Fly   186 ENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKG 250
            ::|||||||:|||||:||:|:|||||||.||:|:::||.|.|||||||||||||||:||||||.|
  Rat   183 KDYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEEGNEFWSALLEKAYAKLNGSYEALVG 247

  Fly   251 GSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNV-TEAETPQGLIRGH 314
            |||.|..||||||:||:||||:.|.||:.|:|||..:.|::||||:..... .||.|.|.|::||
  Rat   248 GSTIEGFEDFTGGISEFYDLKKPPENLYYIIQKALRKGSLLGCSIDVSTAAEAEATTRQKLVKGH 312

  Fly   315 AYSITKVCLIDIVTPNRQGKIP--MIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFD 377
            |||:|.|..:     |..|: |  :||:||||| |.||:|.|||::|||.||...:|.|:....:
  Rat   313 AYSVTGVEEV-----NFHGR-PEKLIRLRNPWG-EVEWSGAWSDNAPEWNYIDPRRKEELDKKAE 370

  Fly   378 RDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDT 442
             ||||||||.|||..:.|:||||||||||:.::.:    ||.:.::.|.||.|.|||||.|:..|
  Rat   371 -DGEFWMSFSDFLKQYSRLEICNLSPDSLSSEEIH----KWNLVLFNGRWTRGSTAGGCLNYPGT 430

  Fly   443 FWHNPQYIITLVDPDEEDEEGQ----CTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELEN 503
            :|.|||:.|.|.:.||:.|||.    |||::.|||||||.::.:|...|:||:|:|.: .:|||:
  Rat   431 YWTNPQFKIHLDEVDEDQEEGTSEPCCTVLLGLMQKNRRRQKRIGQGMLSIGYAVYQI-PKELES 494

  Fly   504 RPQ---GLNFFRYKSSVGRSPH-----FINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVF 560
            ...   |.:||     :||.|.     ::|.|||.:|.:||||.||:|||||:|.::|:|.:|||
  Rat   495 HTDAHLGRDFF-----LGRQPSTCSSTYMNLREVSSRVRLPPGQYLVVPSTFEPFKDGDFCLRVF 554

  Fly   561 SETQNNMEENDDHVGYGGKADTIT--PGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRIL 623
            ||.:....|    :|     ||::  |..|.|:.:|.:.|.:|.||:...|||.|:...:|||:|
  Rat   555 SEKKAKALE----IG-----DTVSGHPHEPHPRDMDEEDEHVRSLFEEFVGKDSEISANQLKRVL 610

  Fly   624 DH--SMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQ 686
            :.  |.|.|             |.|:
  Rat   611 NEVLSKRTD-------------MKFD--------------------------------------- 623

  Fly   687 SNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKA 751
                                      ||:.:.||.|:::||:|.:|.||..||:||..:|..:..
  Rat   624 --------------------------GFNINTCREMISLLDSDGTGSLGPMEFKTLWLKIRTYLE 662

  Fly   752 IFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYID 816
            ||:..|..:.|.:...::|.||..||:.|||:|...:..||......:.|:.|:.|.::::|...
  Rat   663 IFQEMDHNHVGTIEAHEMRTALKKAGFTLNNQVQQTIAMRYACSKLGVDFNGFVACMIRLETLFK 727

  Fly   817 IFKERDTEKNETATFTLEEWI 837
            :|:..|.::|.....:|.||:
  Rat   728 LFRLLDKDQNGIVQLSLAEWL 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	171/303 (56%)
		Calpain_III	416..569	CDD:238132	73/164 (45%)
		EFh_PEF_CalpA_B	600..843	CDD:320071	57/240 (24%)
		EF-hand motif	600..627	CDD:320071	11/28 (39%)
		EF-hand motif	717..747	CDD:320071	13/29 (45%)
		EF-hand motif	748..778	CDD:320071	8/29 (28%)
		EF-hand motif	784..812	CDD:320071	6/27 (22%)
		EF-hand motif	813..843	CDD:320071	7/25 (28%)
Capn8	XP_063128053.1	None