DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpA and CAPN12

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_016881844.1	Gene:	CAPN12 / 147968	HGNCID:	13249	Length:	723	Species:	Homo sapiens

Alignment Length:	808	Identity:	273/808 - (33%)
Similarity:	389/808 - (48%)	Gaps:	166/808 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQFSR-RPD----RHIEWLRPHEIAENPQFFVEGYSR 147
            |.||.|..:||.||.||.||.|||..::|.:.: .||    :.::|:||||....|:|..|..||
Human    30 QSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSR 94

  Fly   148 FDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLP 212
            .||.||.||:||.|||.|:||....|..||:|..|.|:..|||:|||:.||:|:|:||::|||||
Human    95 TDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFGRWMDVVVDDRLP 159

  Fly   213 TYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNL 277
            ...|:||::.|.::||||:.||||||||||||||.::||...||..||||||.|...|::....|
Human   160 VREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSMGL 224

  Fly   278 FTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSIT---KVCLIDIVTPNRQG--KIPM 337
            |:.|:.|..:.|::|.:...|..  |..|.:||::|||||||   ||.|         |  |:.:
Human   225 FSALRHALAKESLVGATALSDRG--EYRTEEGLVKGHAYSITGTHKVFL---------GFTKVRL 278

  Fly   338 IRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLS 402
            :|:|||||. .||.|.||||.|.|..:|.|.:..: |....||||||..:|||.|||.|:||:||
Human   279 LRLRNPWGC-VEWTGAWSDSCPRWDTLPTECRDAL-LVKKEDGEFWMELRDFLLHFDTVQICSLS 341

  Fly   403 PDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQ--- 464
            |:.|....:..|   |.:..::|.|..|..:||.:...:|||.|||:.:||::|||||:|.:
Human   342 PEVLGPSPEGGG---WHVHTFQGRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGP 403

  Fly   465 --------------------CTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDR--ELENRPQG 507
                                |||:::|:|:|||..|..|:..||:||.::.:.:.  .|.:.|:.
Human   404 WGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRS 468

  Fly   508 LNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDD 572
            ...........||| ....|:|..|..|.|||||:||||....:|.:|.:|||||.::.
Human   469 HALLPRLLRADRSP-LSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHT------ 526

  Fly   573 HVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVF 637
                                               ||                ..|.|..:|
Human   527 -----------------------------------AG----------------DRRRDQRRP--- 537

  Fly   638 NRFSNNMAFETQAAGPGDD-------GAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDN 695
                        |..||.|       |.|:...|:.                      :...|..
Human   538 ------------AVSPGGDCSWRGGMGRGSWPALNF----------------------RHAAGPL 568

  Fly   696 PADGGPV---------TANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKA 751
            ||.|..|         .|.|............|..::......:|  |....|:.|...:.:|:|
Human   569 PAPGAGVGAAVSGAGWRARAHTSTPREIGLRTCEQLLQCFGHGQS--LALHHFQQLWGYLLEWQA 631

  Fly   752 IFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYID 816
            ||..:|.:.:|.::.::||.|||:||:||||::...|..||.....::.|:.|:.|...: |.|.
Human   632 IFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRVDFERFVSCVAHL-TCIF 695

  Fly   817 IFKERDTEKNE-TATFTLEEWIERTIYS 843
            ....:..:..| ....|..:|:|...:|
Human   696 CHCSQHLDGGEGVICLTHRQWMEVATFS 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	145/305 (48%)
		Calpain_III	418..565	CDD:279416	59/171 (35%)
		EFh	719..765	CDD:238008	11/45 (24%)
CAPN12	XP_016881844.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920