Protein Alignment CalpA and LOC1280602

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_320457.4
• Gene: LOC1280602 / 1280602
• VectorBaseID: AGAMI1_000303
• Length: 869
• Species: Anopheles gambiae
• Alignment Length: 845
• Identity: 428/845 - (50%)
• Similarity: 537/845 - (63%)
• Gaps: 70/845 - (8%)

  Fly    46 TKRVLPSIKNMRVQ--PLQSQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPL 108
            |..|.|::...|.:  |::...|...|     .|.....| :.||||..:...||.:|.|||||.
Mosquito    48 TTLVKPTLHQSRTRFMPIEFDRNGRAY-----PKPDPQRP-AYVQDYYKLRTDCLRAGKLFEDPE 106

  Fly   109 FPASNESLQFSRRPDR--HIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQES 171
            |||.:.||.||....|  ..:|||||||:.:..|.|:|:||||:|||.|||||||||.||||...
Mosquito   107 FPADDSSLHFSSFAGRQSQYKWLRPHEISPDAVFDVDGFSRFDIQQGLLGDCWLLAAAANLTTFP 171

  Fly   172 NLFFRVIPAEQSFEE------NYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFW 230
            .||.||:|.:....:      :||||||||||::|:|.||::||||||..|:|:|:.|:.|:|||
Mosquito   172 VLFSRVVPDDNDRIQGGRKGVDYAGIFHFRFWRFGQWYDVVVDDRLPTIRGQLVYIKSSTKHEFW 236

  Fly   231 SALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSI 295
            |||||||||||.||||||.|||..|||||||||::|.|::|:||..||.:::|.....:|..|||
Mosquito   237 SALLEKAYAKLFGSYEALSGGSASEAMEDFTGGLTEGYEMKDAPEGLFEMIEKGCNNYAMFACSI 301

  Fly   296 EPDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPE 360
            |......|..|||||::||||||||...:||.||..:|||.::|:|||||||.||||.|||.|||
Mosquito   302 EAGAGEMEQVTPQGLVKGHAYSITKAQAVDIETPRVKGKIQLLRLRNPWGNENEWNGAWSDKSPE 366

  Fly   361 WRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEG 425
            ||:|.|:.|..|||||:.||||||||.||...|||||:|:||||.....|::  :..|....:||
Mosquito   367 WRFINEDTKRSIGLTFEVDGEFWMSFPDFRKCFDRVEMCHLSPDCPIALQES--RFAWRQCAFEG 429

  Fly   426 EWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIG 490
            ||..|.|||||||:.|||||||||:|.|.|||.:||...||:||:|:|||||||||.|:.|||||
Mosquito   430 EWVLGSTAGGCRNYPDTFWHNPQYVIRLDDPDADDEAKLCTLIVSLIQKNRRSKRNKGITCLTIG 494

  Fly   491 FAIYSLNDRELENRPQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEF 555
            ||||.:...:|:.:|....||....|..:|. |||.|||..||:||||.|:|:||||:|||||||
Mosquito   495 FAIYRVEPSDLQRKPLPREFFTSHLSAAKST-FINLREVTCRFRLPPGSYVIIPSTFEPNEEGEF 558

  Fly   556 IIRVFSETQNNMEENDDHVGYGGKADTI---------TPGFPTPKPI-----DPQKEGLRRLFDS 606
            :||||||...||:|||..:|.|...|..         .|..|:||.:     |.|:..:.|||..
Mosquito   559 MIRVFSECAANMQENDSAIGVGTPTDPSPSKPSAGVGPPSKPSPKDVDTGVTDAQRATMERLFIE 623

  Fly   607 IAGKDMEVDWMELKRILDHSMRDDLPKPV--VFNRFSNN----MAFETQAAGPGDDGAGACGLLS 665
            :||:|.||||||||.:||...|:|:.|..  :...:.:.    :..:...||..........|..
Mosquito   624 VAGEDGEVDWMELKLVLDRCFREDIVKASRGISRTYQSTRTTPLEKQQSVAGTASAAISQTSLER 688

  Fly   666 LICGPF--LKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANA---------IVDETH------G 713
            .:||.:  |:.. |.:..|          |||   ..|..||.         .|.:.|      |
Mosquito   689 SLCGMWSTLQNL-FRDIAG----------GDN---SPPAAANGERRELMRSENVTQVHADPSNPG 739

  Fly   714 FSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGY 778
            ||||.|||||||||.|.|||||..||:.||::||:||.:||.||.:.:||:|.|:||.||.||||
Mosquito   740 FSKDACRSMVAMLDEDGSGKLGLAEFQKLLADIARWKGVFKQYDTDQSGRISPFELRAALQSAGY 804

  Fly   779 HLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIERTIYS 843
            .|||.::|:|.|||||::|:|.|||||.|||||:|..||||.||......|.|||||||.:||||
Mosquito   805 TLNNHIINMLMHRYGSKEGEIWFDDFITCAVKIRTMFDIFKARDLSNRNEARFTLEEWITKTIYS 869

  Fly   844  843
            Mosquito   870  869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	181/303 (60%)
		Calpain_III	416..569	CDD:238132	92/152 (61%)
		EFh_PEF_CalpA_B	600..843	CDD:320071	118/265 (45%)
		EF-hand motif	600..627	CDD:320071	16/26 (62%)
		EF-hand motif	717..747	CDD:320071	20/29 (69%)
		EF-hand motif	748..778	CDD:320071	16/29 (55%)
		EF-hand motif	784..812	CDD:320071	18/27 (67%)
		EF-hand motif	813..843	CDD:320071	17/29 (59%)
LOC1280602	XP_320457.4	None