Protein Alignment CalpA and LOC1280423

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_061515896.1
• Gene: LOC1280423 / 1280423
• VectorBaseID: AGAMI1_001723
• Length: 751
• Species: Anopheles gambiae
• Alignment Length: 856
• Identity: 231/856 - (26%)
• Similarity: 357/856 - (41%)
• Gaps: 214/856 - (25%)

  Fly    70 YYGNLGEKSSSLGPYSE--VQDYETIL-------------NSCLAS------------GSLFEDP 107
            ||.|.|.|   |..::.  :||:::.|             |..|.:            |.|.||.
Mosquito    28 YYTNGGPK---LRGWTNGGMQDHQSTLSRPRSAEVITANGNGTLPNGRHMNGVLTRGPGGLHEDL 89

  Fly   108 LFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGEL------GDCWLLAATAN 166
            .||.:..:|  |::  :.|.|:|||::...|||.:..... .:...||      ||..||||...
Mosquito    90 EFPPTPRTL--SKK--KQIVWMRPHDMCARPQFRIAPPGT-PLTARELPEPVGPGDPSLLAALGC 149

  Fly   167 LTQESNLFFRVIPAEQSFE--ENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEF 229
            |:|...|..||:|.||:|:  ..|.|:|.|||||:|||::|.:||||||......:||..:.:.|
Mosquito   150 LSQLPRLLERVVPPEQTFDTANGYCGMFKFRFWQWGKWIEVRVDDRLPTRGDRPAHMHCAQPDIF 214

  Fly   230 WSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCS 294
            |:||||||||||:|.|..||.|:...|::|.||.|                :|.......::|.:
Mosquito   215 WAALLEKAYAKLYGGYTFLKYGTVGRALQDLTGAV----------------VQSVPPSGPLLGGA 263

  Fly   295 IEPDPNVT--------EAETPQ---GLIRGHAYSITKVCLI-----DIVT---PNRQGKIPMIRM 340
            :   |..|        |.||.:   ||:..|.|.:|.:..:     |..|   .:..|...:||:
Mosquito   264 V---PRSTLLIAISGLEKETKRRRSGLLTEHPYCVTGLARVRANSNDSATHGSGSSGGDTSLIRL 325

  Fly   341 RNPW-GNE--AEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLS 402
            |:|| |.|  ..|.|.||:.|.||..:.|..:..:......|.|||||..:||..|..:.:.::.
Mosquito   326 RSPWIGGEWGGVWCGAWSERSWEWNALNERDRELLSSRSSNDCEFWMSVNEFLTRFVVIWLAHIG 390

  Fly   403 PDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTV 467
            ||....:.....:..|..::...:|..|..|||...|:||...|||:.|. |.|   ....:..|
Mosquito   391 PDDWALEPGLHTRAPWRAALAVRQWRGGFNAGGPHKFIDTTATNPQFRIR-VPP---GHPSKAHV 451

  Fly   468 IVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLNFFRYKSSVGRSPHFI-------- 524
            :||:.|| ....|:...|...|||.||.:        |.|:...        :|.::
Mosquito   452 VVAVAQK-YECYRSRNYEDEEIGFTIYEV--------PPGMQRV--------TPQYVSEQMPLDF 499

  Fly   525 ----NTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNM-EENDDHVGYGGKADTIT 584
                |.||:...|.||.|.::::|.... :.||.|::|:|::...:: |.|::::    ....|.
Mosquito   500 APLSNLREIATFFALPAGDFVVMPHAAQ-HREGRFLLRIFADQHTDVWEVNEENL----VIHNIA 559

  Fly   585 PGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILD-HSMRDDLPKPVVFNRFSNNMAFET 648
            ..|...:.||     .|.|:...|....|:|..:|:.||. |.              .||..|.
Mosquito   560 AEFCDERTID-----ARILYKLRARYPHEIDATQLQAILKAHG--------------GNNRGFR- 604

  Fly   649 QAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHG 713
                         ||..:.|||
Mosquito   605 -------------GLGGINCGP------------------------------------------- 613

  Fly   714 FSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTG-----------RVSGF 767
             |.::||.|:|:.|....|:|..|....|:..:..|||.|:.....::|           :||.:
Mosquito   614 -SLELCRGMLALRDPALGGRLSIEHVPALIGLMRFWKAAFRRCGPSSSGTATLSRGIWASKVSSY 677

  Fly   768 QLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFT 832
            .||..|.:.|...:|:||..|..|: :|:.:|..:.:::...::....:.:...|. |.:.:..:
Mosquito   678 CLRGLLWAGGATASNKVLEALVSRF-TRNRQITLEGYLLSMARLHLAHERYHSLDA-KAKASPLS 740

  Fly   833 LEEWIERTIYS 843
            |||.|..||||
Mosquito   741 LEEMILMTIYS 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	112/325 (34%)
		Calpain_III	416..569	CDD:238132	43/165 (26%)
		EFh_PEF_CalpA_B	600..843	CDD:320071	53/254 (21%)
		EF-hand motif	600..627	CDD:320071	9/27 (33%)
		EF-hand motif	717..747	CDD:320071	9/29 (31%)
		EF-hand motif	748..778	CDD:320071	10/40 (25%)
		EF-hand motif	784..812	CDD:320071	6/27 (22%)
		EF-hand motif	813..843	CDD:320071	8/29 (28%)
LOC1280423	XP_061515896.1	None