Protein Alignment CalpA and Capn6

DIOPT Version :9

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_031629.3
• Gene: Capn6 / 12338
• MGIID: 1100850
• Length: 641
• Species: Mus musculus
• Alignment Length: 520
• Identity: 187/520 - (35%)
• Similarity: 280/520 - (53%)
• Gaps: 55/520 - (10%)

  Fly    81 LGPYSEV---QDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFV 142
            :||..::   |.|:.:...|:..|.||.||.|...|:||.|:|.....:.|.||.:|:::|...|
Mouse     1 MGPPLKLFKNQKYQELKQECMKDGRLFCDPTFLPENDSLFFNRLLPGKVVWKRPQDISDDPHLIV 65

  Fly   143 EGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFE------ENYAGIFHFRFWQYGK 201
            ...|...:.||.||:..:::|.:.|..:.:.:.:.||..:..|      |.||||||||||.:|:
Mouse    66 GNISNHQLIQGRLGNKAMISAFSCLAVQESHWTKAIPNHKDQEWDPRKPEKYAGIFHFRFWHFGE 130

  Fly   202 WVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSE 266
            |.:|:|||.|||.||:|::..||..||||:||||||||||.|.||||.|.:..:.:.||||.::|
Mouse   131 WTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIMDFTGTLAE 195

  Fly   267 --------WYDLKEAPGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITKV- 321
                    :.||.|....||..|.|...:..::.|||| |.....|.||..||::|:.|::|.:
Mouse   196 IIDMQKGRYTDLVEEKYKLFGELYKTFTKGGLICCSIESPSQEEQEVETDWGLLKGYTYTMTDIR 260

  Fly   322 ------CLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDG 380
                  .|:::.:..   |:.|:|:|||.|.: ||:||||:.|.||:.:....:..:||....||
Mouse   261 KLRLGERLVEVFSTE---KLYMVRLRNPLGRQ-EWSGPWSEISEEWQQLTVTDRKNLGLVMSDDG 321

  Fly   381 EFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWT----PGVT-AGGCRNFL 440
            |||||.:||.::|.::.:|        .:..|....:.|:....|.||    |.:. :|||.|..
Mouse   322 EFWMSLEDFCHNFHKLNVC--------RNVNNPVFGRKELESVVGCWTVDDDPLMNRSGGCYNNR 378

  Fly   441 DTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGM-ECLTIGFAIYSLNDRELENR 504
            |||..|||||.|:      .|:|. .||::|.||:.|:.|.||. :...|||.::.:.    .||
Mouse   379 DTFLQNPQYIFTV------PEDGH-KVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVE----MNR 432

  Fly   505 PQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEE 569
            ...|:....:...|.|. :|:||.|.....|..|.|::||:.|......||::|:|||....:.|
Mouse   433 RFRLHHLYIQERAGTST-YIDTRTVFLSKYLKKGSYVLVPTMFQHGRTSEFLLRIFSEVPVQLRE 496

  Fly   570  569
            Mouse   497  496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	124/317 (39%)
		Calpain_III	418..565	CDD:279416	53/152 (35%)
		EFh	719..765	CDD:238008
Capn6	NP_031629.3	CysPc	13..351	CDD:128526	130/349 (37%)
		Domain III	344..495		54/162 (33%)
		Calpain_III	349..497	CDD:238132	54/160 (34%)
		C2_Calpain	514..639	CDD:176011

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820