DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpA and Capn5

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_006507338.1	Gene:	Capn5 / 12337	MGIID:	1100859	Length:	653	Species:	Mus musculus

Alignment Length:	512	Identity:	212/512 - (41%)
Similarity:	309/512 - (60%)	Gaps:	51/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 EVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDV 150
            |.|:|..:..:||....|||||||||:::||.:...|...:.|.||.:|.::|:.||:|.|..|:
Mouse    22 EDQNYSALKRACLRKKVLFEDPLFPATDDSLYYKGTPGPTVRWKRPKDICDDPRLFVDGISSHDL 86

  Fly   151 QQGELGDCWLLAATANLTQESNLFFRVIP--AEQSFE----ENYAGIFHFRFWQYGKWVDVIIDD 209
            .||::|:||.:||.::|....:|:.:|||  .||.:.    ::|||||||.||::|:|||||:||
Mouse    87 HQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWNPEKPDSYAGIFHFNFWRFGEWVDVIVDD 151

  Fly   210 RLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAP 274
            ||||.|.:|:|.||..|||||.||:|||||||.|.|:||.||:|.:|:.||||||||..||.|..
Mouse   152 RLPTVNNQLIYCHSNSKNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGD 216

  Fly   275 --------GNLFTILQKAAERNSMMGCSIEPDPNVT----EAETPQGLIRGHAYSITKVCLI--- 324
                    ..||..:.|...|..::..||:.   ||    ||....||::||||::|.|..:
Mouse   217 LATDEAKRNQLFERVLKVHSRGGLISASIKA---VTAADMEARLACGLVKGHAYAVTDVRKVRLG 278

  Fly   325 -DIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQD 388
             .::...:..|:.|||:||||| |.||.|||||:|.||:.:.:.::.::|:|...||||||:|:|
Mouse   279 HGLLAFFKSEKLDMIRLRNPWG-EREWTGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFED 342

  Fly   389 FLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWT----PGVT-AGGCRNFLDTFWHNPQ 448
            ...:|..:..|.|...|..     |..:.||.:...|.||    |... :|||.|..|||:.|||
Mouse   343 MCRYFTDIIKCRLINTSYL-----SIHKTWEEARLHGAWTRHEDPQQNRSGGCINHKDTFFQNPQ 402

  Fly   449 YIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGM-ECLTIGFAIYSLNDRELENRPQGLNFFR 512
            |:..:..|::|       |::::.|:.:||.|..|. |.|.|||.||.:.    |||...::..:
Mouse   403 YVFEVKKPEDE-------VLISIQQRPKRSTRREGKGENLAIGFDIYKVE----ENRQYRMHSLQ 456

  Fly   513 YKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEE 569
            :|::   |..:||:|.|..|.:||.|.|:|:|:||:|...|||::|||::..:|..|
Mouse   457 HKAA---SSIYINSRSVFLRTELPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRE 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	143/317 (45%)
		Calpain_III	418..565	CDD:279416	57/152 (38%)
		EFh	719..765	CDD:238008
Capn5	XP_006507338.1	Peptidase_C2	40..354	CDD:366222	143/317 (45%)
		Calpain_III	365..511	CDD:238132	59/160 (37%)
		C2_Calpain	528..651	CDD:176011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4459
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.770