DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and Capn1

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001103974.1	Gene:	Capn1 / 12333	MGIID:	88263	Length:	713	Species:	Mus musculus

Alignment Length:	790	Identity:	325/790 - (41%)
Similarity:	456/790 - (57%)	Gaps:	121/790 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 EKSSSLGPYSEV-----QDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRH-----IEWLR 130
            :|...||.:...     |||||:...||.||.||:|..||..:.||.|.......     |:|.|
Mouse    23 DKELGLGRHENAIKYLGQDYETLRARCLQSGVLFQDEAFPPVSHSLGFKELGPHSSKTYGIKWKR 87

  Fly   131 PHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFR 195
            |.|:..||||.|:|.:|.|:.||.|||||||||.|:||....:..||:|..|||::.|||||||:
Mouse    88 PTELMSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQDGYAGIFHFQ 152

  Fly   196 FWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDF 260
            .||:|:||||:|||.|||.:|:|:::||.:.||||||||||||||::||||||.||.|.||.|||
Mouse   153 LWQFGEWVDVVIDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDF 217

  Fly   261 TGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITKVCLI 324
            ||||:|||||::||.:|:.|:.||.||.|::||||. .|....||.|.:.|:||||||:|....:
Mouse   218 TGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTGAKQV 282

  Fly   325 DIVTPNRQG-KIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQD 388
                 ..|| ::.:|||||||| |.||.|||||||.||..:...::.::.:..: ||||||||:|
Mouse   283 -----TYQGQRVNLIRMRNPWG-EVEWKGPWSDSSYEWNKVDPYEREQLRVKME-DGEFWMSFRD 340

  Fly   389 FLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITL 453
            |:..|.::|||||:||:|    ::...|.|..:.|||.|..|.|||||||:..|||.|||:.|.|
Mouse   341 FIREFTKLEICNLTPDAL----KSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWVNPQFKIRL 401

  Fly   454 VDPDEEDE----EGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGL--NFFR 512
            .:.|:.|:    |..|:.::|||||:||.:|..|.:..|||||:|.: .|||..:|..|  :||.
Mouse   402 EEVDDADDYDNRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQV-PRELAGQPVHLKRDFFL 465

  Fly   513 YKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYG 577
            ..:|..:|.||||.|||..|.:||||.|::|||||:||:||:|::|.|||.:...:|.||.
Mouse   466 ANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQELDDQ---- 526

  Fly   578 GKADTITPGFPTPKPIDPQK--EGLRRLFDSIAGKDMEVDWMELKRILDH--SMRDDLPKPVVFN 638
                 |....|..|.:..::  :..:.||..:||.|||:...||:.||:.  |...||
Mouse   527 -----IQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKHKDL------- 579

  Fly   639 RFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVT 703

Mouse   580 ----------------------------------------------------------------- 579

  Fly   704 ANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQ 768
                  .|:|||.:.|||||.::|.|.:||||..||..|.:.|..:..||:.:|::.:|.:|.::
Mouse   580 ------RTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYE 638

  Fly   769 LREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTL 833
            :|.|:.:||:.||.::..::..||...|..:.||:|:.|.|:::|....||..||:.:...||.|
Mouse   639 MRMAIEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKLLDTDLDGVVTFDL 703

  Fly   834 EEWIERTIYS 843
            .:|::.|:::
Mouse   704 FKWLQLTMFA 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	161/302 (53%)
		Calpain_III	418..565	CDD:279416	76/152 (50%)
		EFh	719..765	CDD:238008	19/45 (42%)
Capn1	NP_001103974.1	Peptidase_C2	56..352	CDD:279042	161/302 (53%)
		Domain III	355..525		81/174 (47%)
		Calpain_III	366..518	CDD:279416	76/152 (50%)
		Linker	526..541		3/23 (13%)
		PTZ00184	537..680	CDD:185504	51/220 (23%)
		Domain IV	542..712		62/247 (25%)
		EF-hand_8	556..609	CDD:290545	25/130 (19%)
		EFh	589..643	CDD:238008	21/53 (40%)
		EFh	622..704	CDD:298682	26/81 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4099
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	640	1.000	Inparanoid score	I814
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm8819
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870