DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and CAPN11

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_011512576.1	Gene:	CAPN11 / 11131	HGNCID:	1478	Length:	744	Species:	Homo sapiens

Alignment Length:	807	Identity:	317/807 - (39%)
Similarity:	457/807 - (56%)	Gaps:	121/807 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 QPLQSQSNSTLYYGNLGEKSSSLGPYSEVQD-----YETILNSCLASGSLFEDPLFPASNESLQF 118
            :|..:.:....:..|...|:..:|.:...|:     :|.:..:||..|.|||||||||...||.|
Human    35 EPTFTDTGMVAHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPSSLGF 99

  Fly   119 -----SRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVI 178
                 :.:..::|.|.||.:|..||.|.::|.|..|:.||.|||||||||..:||....|.:||:
Human   100 KDLGPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVV 164

  Fly   179 PAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHG 243
            |..|||::||||||||:.||:|:||:|::||||||.|.:|:::||||::||||||||||||||.|
Human   165 PRGQSFKKNYAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSG 229

  Fly   244 SYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETP 307
            |||||.||||.|.:|||||||::.:.|:..|.||..:|:||.||:|:|||||| ...:..|:.|.
Human   230 SYEALSGGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTD 294

  Fly   308 QGLIRGHAYSITKVCLIDIVTPNRQGKI-PMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAE 371
            :.|:||||||:|.  |.|:   :.:||: .:||:||||| ..||||.||||:.||..:..:.:.:
Human   295 KMLVRGHAYSVTG--LQDV---HYRGKMETLIRVRNPWG-RIEWNGAWSDSAREWEEVASDIQMQ 353

  Fly   372 IGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGC 436
            : |....|||||||:|||||:|..:|||||:||:|:.|.    |..|..:.|||.|..|.:||||
Human   354 L-LHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDY----KSYWHTTFYEGSWRRGSSAGGC 413

  Fly   437 RNFLDTFWHNPQYIITLVDPD--EEDEEGQ---CTVIVALMQKNRRSKRNMGMECLTIGFAIYSL 496
            ||...|||.|||:.|:|.:.|  |:|.||.   ||.:|||||||.|..|..|.:..||||.:|::
Human   414 RNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAV 478

  Fly   497 NDRELENRPQGLN----FFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFII 557
             .:|.:| .|.::    ||......|.|..|.|:|||.::.:||||.|:|:||||:|:.:.:|::
Human   479 -PKEFQN-IQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLL 541

  Fly   558 RVFSETQNNMEENDDHVGYGG--KADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELK 620
            |||:|..:...|.|: |.|..  :.:.::.        |...:....||..:||:..|:...||:
Human   542 RVFTEKHSESWELDE-VNYAEQLQEEKVSE--------DDMDQDFLHLFKIVAGEGKEIGVYELQ 597

  Fly   621 RILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMND 685
            |:|                  |.||.:.::.
Human   598 RLL------------------NRMAIKFKSF---------------------------------- 610

  Fly   686 QSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWK 750
                                    :|.||..|.||.|:.::|.|.|||||..||:.|..::.||.
Human   611 ------------------------KTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWM 651

  Fly   751 AIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYI 815
            .||:..|.:::|.::.:::|..:..||..|||:|:.||..||...|..|.||.||.|.:::||..
Human   652 DIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMF 716

  Fly   816 DIFKERDTEKNETATFTLEEWIERTIY 842
            ..|...|.:.......:||:|::.|::
Human   717 TFFLTMDPKNTGHICLSLEQWLQMTMW 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	163/302 (54%)
		Calpain_III	418..565	CDD:279416	70/155 (45%)
		EFh	719..765	CDD:238008	19/45 (42%)
CAPN11	XP_011512576.1	Peptidase_C2	85..381	CDD:279042	163/302 (54%)
		Calpain_III	395..549	CDD:279416	70/155 (45%)
		EFh	620..670	CDD:298682	19/49 (39%)
		EFh	651..706	CDD:298682	19/54 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4108
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48339
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm8590
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.830