DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and CAPN9

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_011542319.1	Gene:	CAPN9 / 10753	HGNCID:	1486	Length:	721	Species:	Homo sapiens

Alignment Length:	736	Identity:	324/736 - (44%)
Similarity:	443/736 - (60%)	Gaps:	106/736 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 YSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRF 148
            :|..|.:|.:...||..|:||||..|||||.||.:|.||.....|.||.||.:||:|.:.|.:|.
Human    23 HSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRT 87

  Fly   149 DVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLPT 213
            |:.||||||||||||.|:||.......||||.:|||...|||||||:|||:.:|:||:|||||||
Human    88 DICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPT 152

  Fly   214 YNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLF 278
            :...|:::||.:.|||||||||||||||:||||||||||..||||||||||:|.:..||||.|.:
Human   153 FRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFY 217

  Fly   279 TILQKAAERNSMMGCSIEP-DPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMRN 342
            .||:||.:|.|::||.|:. ....:||.||.|||:|||||:|.:..:..    |..:|.:||:||
Human   218 EILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSF----RGQRIELIRIRN 278

  Fly   343 PWGNEAEWNGPWSDSSPEWRYI-PEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSL 406
            ||| :.||||.|||||||||.: |.|||.......| ||||||:|:||..|||:||||||:||:|
Human   279 PWG-QVEWNGSWSDSSPEWRSVGPAEQKRLCHTALD-DGEFWMAFKDFKAHFDKVEICNLTPDAL 341

  Fly   407 TEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTVIVAL 471
            .||    ...|||:::::|.|..|.|||||||||||||.|||..::|.:.||..||  |:.:|||
Human   342 EED----AIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE--CSFLVAL 400

  Fly   472 MQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLN--FFRYKSSVGRSPHFINTREVCARFK 534
            |||:||..:..|...||||:|||...|::     :.||  ||||.:|..||..|||.|||..|||
Human   401 MQKDRRKLKRFGANVLTIGYAIYECPDKD-----EHLNKDFFRYHASRARSKTFINLREVSDRFK 460

  Fly   535 LPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKE- 598
            ||||.|:::||||:|::|.:|.:|:|||.:....:.|      |..|...|..|.|.|.|.:.|
Human   461 LPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMD------GNVDIDLPEPPKPTPPDQETEE 519

  Fly   599 --GLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGAC 661
              ..|.||:.:||:||||...||:.:|:..::.  .|.:.|.:
Human   520 EQRFRALFEQVAGEDMEVTAEELEYVLNAVLQK--KKDIKFKK---------------------- 560

  Fly   662 GLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAML 726
              ||||.                                                  |:::::::
Human   561 --LSLIS--------------------------------------------------CKNIISLM 573

  Fly   727 DADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHR 791
            |...:|||.|:||:....::.:|..:|..:|.:.:|.:|.::||.||.:||:.|::.:|.::..|
Human   574 DTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLR 638

  Fly   792 YGSRDGKIAFDDFIMCAVKIK 812
            |...:.::.||||:.|.|:::
Human   639 YADEELQLDFDDFLNCLVRLE 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	174/297 (59%)
		Calpain_III	418..565	CDD:279416	78/148 (53%)
		EFh	719..765	CDD:238008	12/45 (27%)
CAPN9	XP_011542319.1	Peptidase_C2	43..335	CDD:279042	174/297 (59%)
		Calpain_III	349..491	CDD:279416	78/148 (53%)
		PTZ00184	514..657	CDD:185504	48/218 (22%)
		EFh	566..621	CDD:238008	16/54 (30%)
		EFh	600..652	CDD:298682	17/51 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143530
Domainoid	1	1.000	356	1.000	Domainoid score	I986
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38208
Inparanoid	1	1.050	643	1.000	Inparanoid score	I809
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm8590
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2435
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.830