Protein Alignment CalpA and capn14

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_031758480.1
• Gene: capn14 / 101732339
• XenbaseID: XB-GENE-22068150
• Length: 722
• Species: Xenopus tropicalis
• Alignment Length: 789
• Identity: 258/789 - (32%)
• Similarity: 379/789 - (48%)
• Gaps: 148/789 - (18%)

  Fly    39 FIKKEADTKRVLPSIKNMRVQPLQSQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSL 103
            |||....||.:|.:....:.:.|||                        |||:.:|...|....|
 Frog    12 FIKGGKKTKPLLRTGTLRKPRRLQS------------------------QDYQALLEKSLGGKQL 52

  Fly   104 FEDPLFPASNESL----QFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAAT 164
            |.|..||||..|:    ...:.|| .:||.||||:.:||||..|..|.|.:.||...:||.|||.
 Frog    53 FVDETFPASLASIGSGCLLDKLPD-CVEWKRPHELVQNPQFCTENASEFGLHQGLTENCWFLAAL 116

  Fly   165 ANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGE--LMYMHSTEKN 227
            ::||...::...|:|..|||.::|.||||||||::|:||||::|||||. |||  |:::.|..||
 Frog   117 SSLTFHPDILTNVVPQNQSFNKSYGGIFHFRFWRFGEWVDVVVDDRLPV-NGEGKLLFVSSVRKN 180

  Fly   228 EFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMG 292
            .||..|||||||||.||||.::.|...||:.||||||:....:.:||.:||.|:.:|....|:||
 Frog   181 LFWGPLLEKAYAKLCGSYEDMQIGQVSEALVDFTGGVNMSIKMAQAPPDLFQIMMRAQNSGSLMG 245

  Fly   293 CSIEPDPNVTEAETPQGLIRGHAYSITKVCLIDI--VTPNRQGKIPMIRMRNPWGNEAEWNGPWS 355
            |..:..|   |.....||:.||||::..|..:.:  ||.|      ::::||||| :.||.|.||
 Frog   246 CQTQTGP---ERVLDNGLVTGHAYTVMDVRQVTVKSVTEN------LVKLRNPWG-KIEWTGKWS 300

  Fly   356 DSSPEWRYIPEEQKAEIGLTFDR-DGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWE 419
            |..|:|..:  ..|..:.|...| |||||||.:||..||..:.||.|:||.::.:   .|| :|.
 Frog   301 DRCPKWEQL--SYKERLFLRKRREDGEFWMSIEDFEAHFVELVICKLTPDLMSHE---IGK-EWT 359

  Fly   420 MSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDE-EDEEGQCTVIVALMQKNRRSKRNMG 483
            :||..|.|:.|.||||...:.:::|.||||.:.::..|: |.....|.|:|:||||.....||..
 Frog   360 LSMQCGRWSAGSTAGGRMTYTESYWLNPQYRLKILKGDDMEKFTNSCNVLVSLMQKQSHKHRNQS 424

  Fly   484 MECLTIGFAIY--SLNDRELENRPQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPST 546
            .. |.||.:::  ....:.::..||  .||.....:.....|||.|||...:.|.||.|:|:|||
 Frog   425 PP-LYIGMSVFLVPFEYQGVKRLPQ--KFFLTHRPINNKCVFINEREVTQDYHLMPGSYVIIPST 486

  Fly   547 FDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFP--TPKPIDPQKEGL-RRLFDSIA 608
            .:||:|.|||:||||......|:            |.:|...  ..|..:..:.|: ...|:...
 Frog   487 AEPNQECEFILRVFSRKHLLQEQ------------TESPNIVLCCKKIAERHRNGIWETFFNKYF 539

  Fly   609 GKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLK 673
            .|..|:...:|:::|                  |.:.:......||.
 Frog   540 EKHPEIKVAQLQQLL------------------NKITWTNSKQAPGK------------------ 568

  Fly   674 GTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEE 738
                                                    ||.|.|:.::|:||...||.|..:|
 Frog   569 ----------------------------------------FSFDDCKLIMALLDMKTSGTLNMQE 593

  Fly   739 FETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDD 803
            |..|...:..::.||:..||:.||.:....|:.|:...|..|:.:..|::..|||....|::|::
 Frog   594 FRGLWKRLLSYQEIFQRRDVDKTGYLKLNDLQAAIKERGITLHRQFYNLVALRYGDSLLKMSFEN 658

  Fly   804 FIMCAVKIK 812
            |....::|:
 Frog   659 FACLMLRIE 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	136/304 (45%)
		Calpain_III	416..569	CDD:238132	57/155 (37%)
		EFh_PEF_CalpA_B	600..843	CDD:320071	39/214 (18%)
		EF-hand motif	600..627	CDD:320071	5/27 (19%)
		EF-hand motif	717..747	CDD:320071	11/29 (38%)
		EF-hand motif	748..778	CDD:320071	8/29 (28%)
		EF-hand motif	784..812	CDD:320071	7/27 (26%)
		EF-hand motif	813..843	CDD:320071	258/789 (33%)
capn14	XP_031758480.1	Peptidase_C2	53..344	CDD:459889	136/304 (45%)
		Calpain_III	365..500	CDD:460050	51/137 (37%)
		EFh_PEF	532..668	CDD:355382	39/212 (18%)
		EF-hand motif	532..558	CDD:320054	6/43 (14%)
		EF-hand motif	573..602	CDD:320054	10/28 (36%)
		EF-hand motif	603..632	CDD:320054	8/28 (29%)
		EF-hand motif	639..667	CDD:320054	7/27 (26%)