Protein Alignment CalpA and capn10l

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_031758129.1
• Gene: capn10l / 100497805
• XenbaseID: XB-GENE-5889689
• Length: 708
• Species: Xenopus tropicalis
• Alignment Length: 829
• Identity: 249/829 - (30%)
• Similarity: 374/829 - (45%)
• Gaps: 179/829 - (21%)

  Fly    60 PLQSQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESL------QF 118
            |:...:|.....|  |.:|.::   .:.||:..:.:..|..|.||.|..|||....:      :|
 Frog     4 PMDRNANQLKLSG--GSESPTM---FKNQDFHALRDLHLRKGVLFNDEEFPADMRVIGPHLIDEF 63

  Fly   119 SRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQS 183
            .   ..::||.||.|..:||...|:|.|.||:.|.::||||:|:...::||:..|...:|||:|.
 Frog    64 K---IHNMEWRRPPEFCKNPHLIVDGASYFDIVQSKIGDCWVLSTIGSVTQKQTLLRNIIPADQG 125

  Fly   184 FEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEAL 248
            |..|||||||||||..||||||:||||||..||:...:.::...|:|..|||||||||.|||:.|
 Frog   126 FTRNYAGIFHFRFWYSGKWVDVVIDDRLPFLNGDFFSVRASCAKEYWPCLLEKAYAKLLGSYQNL 190

  Fly   249 KGGSTCEAMEDFTGGVSEWYDLKEAP---GNLFTILQKAAERNSMMGCSIE-------------- 296
            ..|...||:.:|||.::....||...   .:::.::.|:::: :::.|..|
 Frog   191 HWGDPAEALVNFTGALTLTLKLKGGDLHHSDIWEMVHKSSQK-ALITCISEKAEVMTHNRRYSVP 254

  Fly   297 -----------PDP---NVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMRNPWGNE 347
                       .||   .:.......||:..|||::|     |.....|:|.:.:||:.|||| .
 Frog   255 SAMEGRDERRRSDPANKYIENIHVDNGLVDRHAYTVT-----DTAQVYREGCVNLIRLWNPWG-R 313

  Fly   348 AEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQN 412
            .||.|.|||:...|..|..|.:.::. |...|||||||::.|:..|.||.||  ||   |.|..|
 Frog   314 GEWIGRWSDNCSWWNDIDPEDRKKLN-TKREDGEFWMSWETFVQQFSRVIIC--SP---TLDFLN 372

  Fly   413 SGK--RKWEMSMYEGEWTPGVTAGGCRNFL--DTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQ 473
            .|:  |.|..:.||..|.   .|.|..:..  |.|..||||:|. :.|.:|.::|. .||::|||
 Frog   373 WGRDQRSWHKTSYENIWP---KASGLEDSFNKDLFCKNPQYLIR-ISPSDEVQKGY-NVIISLMQ 432

  Fly   474 KNRRSKRNMGMECLTIGFAIYSLNDRELENRPQ----GLNFFR-YKSSVGRSPHFINTREVCARF 533
             |.|:::..|...|.|||.: |..|.||.: ||    |..|.: .:|.:    |....|:|....
 Frog   433 -NHRNRQKFGRGWLPIGFLV-SKVDAELPD-PQRKMPGSFFLKDLQSGI----HINKQRDVTKGL 490

  Fly   534 KLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKE 598
            ||..|.|:|.|...|.::|..|:::||..:|....|..|...:
 Frog   491 KLASGRYVITPFNADRSQESSFLLQVFLRSQGCTVELGDSQSF---------------------- 533

  Fly   599 GLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGL 663
                                ||       .::..:...|      |.:.||..
 Frog   534 --------------------LK-------NEEKTQEETF------MKYATQGG------------ 553

  Fly   664 LSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADG-GPVTANAIVDETHG---FSKDVCRSMVA 724
                              .||.|..::.:.|..:.| .|          ||   ||.:..|||:|
 Frog   554 ------------------KMNSQDLQKFLNDVISKGFAP----------HGGIRFSTEASRSMLA 590

  Fly   725 MLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLG 789
            .:|...:|||..|.|..|...:..:||||...||:..|.:...:||:|..|||..:::..|.:|.
 Frog   591 SMDFTCNGKLELEFFMRLWRYLNHFKAIFTDVDVDQNGFIGLSELRKAAKSAGMAVSSDQLTILL 655

  Fly   790 HRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIE 838
            .|||..:.|:.|:|::.|.|::|:....| :..|...:....|..:|::
 Frog   656 LRYGDYEMKLNFEDYLCCMVRLKSAFKRF-QMLTSDGKGVYLTEGKWLK 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	122/332 (37%)
		Calpain_III	416..569	CDD:238132	53/159 (33%)
		EFh_PEF_CalpA_B	600..843	CDD:320071	55/243 (23%)
		EF-hand motif	600..627	CDD:320071	2/26 (8%)
		EF-hand motif	717..747	CDD:320071	11/29 (38%)
		EF-hand motif	748..778	CDD:320071	12/29 (41%)
		EF-hand motif	784..812	CDD:320071	10/27 (37%)
		EF-hand motif	813..843	CDD:320071	4/26 (15%)
capn10l	XP_031758129.1	Peptidase_C2	43..365	CDD:459889	123/334 (37%)
		Calpain_III	400..517	CDD:460050	43/125 (34%)
		EFh_PEF_CAPN13_14	541..708	CDD:320070	53/210 (25%)
		EF-hand motif	541..568	CDD:320070	8/62 (13%)
		EF-hand motif	584..613	CDD:320070	11/28 (39%)
		EF-hand motif	614..644	CDD:320070	12/29 (41%)
		EF-hand motif	650..678	CDD:320070	10/27 (37%)
		EF-hand motif	680..708	CDD:320070	4/25 (16%)