DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and capn6

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_031747775.1	Gene:	capn6 / 100494450	XenbaseID:	XB-GENE-992087	Length:	643	Species:	Xenopus tropicalis

Alignment Length:	509	Identity:	209/509 - (41%)
Similarity:	290/509 - (56%)	Gaps:	44/509 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 EVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDV 150
            :.|:|..:...|:.:|.|||||.||||:|||.:|:.||..|||.||.|:.|:|..||:|.|..|:
Frog     9 KTQNYHELKKECIKNGKLFEDPEFPASDESLFYSKAPDLRIEWKRPKELCEDPHLFVDGISSHDL 73

  Fly   151 QQGELGDCWLLAATANLTQESNLFFRVIP--AEQSFE----ENYAGIFHFRFWQYGKWVDVIIDD 209
            .||.||:||.:||.:.|..:..|:.:||.  .:|.::    ..|||||||:||..|.||||:|||
Frog    74 HQGRLGNCWFVAACSCLALKKALWTKVISNWKKQEWDPKRPHRYAGIFHFKFWCLGDWVDVVIDD 138

  Fly   210 RLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEA- 273
            |||:.:|.|:|.||..||||||||||||||||.||||||.||:|.:|:.||||.|:|.::|.:.
Frog   139 RLPSVDGNLVYCHSNVKNEFWSALLEKAYAKLAGSYEALDGGNTADAIVDFTGAVTESFELDKGD 203

  Fly   274 -------PGNLFTILQKAAERNSMMGCSIEP-DPNVTEAETPQGLIRGHAYSITKVCLID----I 326
                   ...||..|.|......::.|.|:| ..|..||.|..||::|||||:|.:..:.    |
Frog   204 YRTSLMEQTKLFQELLKVYRAGGLISCYIKPVSSNDMEAVTSYGLVKGHAYSVTAIKKMPVGQRI 268

  Fly   327 VTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLN 391
            :......|:.||||||||| :.||.|.|||.|.||..:...:||.:|||...||||||:|:|:..
Frog   269 LCFGNSNKLFMIRMRNPWG-KREWKGAWSDESEEWNKVSRSEKATLGLTVADDGEFWMTFEDWCL 332

  Fly   392 HFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGV-----TAGGCRNFLDTFWHNPQYII 451
            .|...::|.:...|..     |..:.|:.....|.|:...     .:|||.| ..||:.|||||.
Frog   333 SFTHADVCRILNTSYL-----SCYKTWKQEEVHGAWSKNTDPLLNRSGGCFN-ETTFFQNPQYIF 391

  Fly   452 TLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGM-ECLTIGFAIYSLNDRELENRPQGLNFFRYKS 515
            .:  ..:|||     |:::|.||::|..:..|. ....|||.|:.:   || ||...::....:.
Frog   392 EV--RKKEDE-----VLISLQQKDQRIHKKDGKGNNFIIGFEIFKV---EL-NREYRIHMISGQE 445

  Fly   516 SVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEE 569
            ...|| .:||.|.:..|..|..|.|:|:|:||.|.....||:|:|::..:...|
Frog   446 KTLRS-SYINLRAIFLRKVLTHGRYVIIPTTFHPGISSSFILRLFTDESSRFRE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	151/314 (48%)
		Calpain_III	418..565	CDD:279416	49/152 (32%)
		EFh	719..765	CDD:238008
capn6	XP_031747775.1	Peptidase_C2	27..341	CDD:395523	151/314 (48%)
		Calpain_III	361..489	CDD:395848	47/140 (34%)
		C2_Calpain	516..640	CDD:176011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920