DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and capn12

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_031746547.1	Gene:	capn12 / 100486294	XenbaseID:	XB-GENE-1008507	Length:	674	Species:	Xenopus tropicalis

Alignment Length:	782	Identity:	237/782 - (30%)
Similarity:	347/782 - (44%)	Gaps:	152/782 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRH---IEWLRPHEIAENPQFFVEG 144
            |.||..|            |||.|..||...|         .|   |||.||.||...|:|.::|
Frog    24 PQSEPPD------------SLFIDSNFPWEEE---------LHVGCIEWRRPQEICAKPRFILDG 67

  Fly   145 YSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDD 209
            .:|.||.||:|.:||.|:|.|.|:....|..:|:...|.|...|.|.|.|:|||||:||.|.|||
Frog    68 ATRMDVCQGKLSNCWFLSAVACLSLYPQLLEKVVLPGQDFVGAYDGKFRFQFWQYGQWVLVEIDD 132

  Fly   210 RLPT----------YNG---ELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFT 261
            ||||          :|.   ||::|||.:|:||||:|||||||||.|.|.||:.|...||:.|.|
Frog   133 RLPTVRIQRNEEAAHNREEYELLFMHSWKKDEFWSSLLEKAYAKLKGGYSALQLGFAGEALVDMT 197

  Fly   262 GGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAETPQ----GLIRGHAYSITKVC 322
            |||::..........|:..|....::.::..|      ..||.|...    |::..|.||:|...
Frog   198 GGVAQTCYTNGPLNMLWVSLSHLLQQGALTCC------GNTEGELEMANSLGILSHHMYSVTGAK 256

  Fly   323 LIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQ 387
            .:..:    .|.:.::|:|||||: .||:|||.|...||..:...::.|:...  .||||||..:
Frog   257 QVQTL----HGSVSLLRVRNPWGH-TEWSGPWRDGGSEWLSVINIKEIEVENL--EDGEFWMDVE 314

  Fly   388 DFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIIT 452
            ||..:|..:|||:|.|:||:  |..|..|.||...|||.|...:::||.....|.||.||||.::
Frog   315 DFQKNFQVLEICHLGPESLS--QIGSVARPWEYVTYEGCWLKDISSGGSIECKDHFWMNPQYTLS 377

  Fly   453 LVDPDEEDEEGQCTVIVALMQKNRRSK-RNMGMECLTIGFAIYSLNDRELENRPQGLNFFRYKSS 516
            ||..| .|....|::||::|.|::|.| ::|.:.|.     |:..|:..:....:.|...:...|
Frog   378 LVTED-TDSNPMCSIIVSVMLKHKRLKAKDMRVMCY-----IFQGNEDHVYLSQEILQCSQPVLS 436

  Fly   517 VGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKAD 581
            |....   ..||......||||.|:|:||....::||||:||:.:|..::....|.....|..|
Frog   437 VSSCD---KKREAVLSTSLPPGRYIIIPSLETTSDEGEFLIRILTEKGSSARPTDSKAACGESA- 497

  Fly   582 TITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAF 646
                 ..:.:|.|.|......||   :.:|..:....|..:|...|:|                |
Frog   498 -----AQSVRPTDEQCHSRFLLF---SDQDGRITNEGLHHLLTSLMKD----------------F 538

  Fly   647 ETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDET 711
            :                      |.|.....|.
Frog   539 D----------------------PLLPEITMES-------------------------------- 549

  Fly   712 HGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSA 776
                   |..::|.||....|.|.:|:|:.|...|.....||..........:...|:..||.||
Frog   550 -------CCRLIASLDTSAEGALCWEQFDRLWKNIITGSLIFSNLQSSKDRNLDKDQIGAALQSA 607

  Fly   777 GYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIERTI 841
            |...:|.::.::..||..:||.:::..||.|.:|||....:|:..|:..:.|.:....:|::..:
Frog   608 GLITDNFLVRLVQLRYADKDGSLSYSAFICCLLKIKAVTGMFEVADSTGSGTVSLNYHQWLQLAL 672

  Fly   842 YS 843
            ||
Frog   673 YS 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	121/315 (38%)
		Calpain_III	418..565	CDD:279416	50/147 (34%)
		EFh	719..765	CDD:238008	12/45 (27%)
capn12	XP_031746547.1	Peptidase_C2	33..327	CDD:395523	121/315 (38%)
		Calpain_III	350..476	CDD:395848	44/134 (33%)
		EFh_PEF	507..674	CDD:355382	45/246 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020