Protein Alignment CalpA and capn3b

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_001230250.1
• Gene: capn3b / 100034405
• ZFINID: ZDB-GENE-041001-149
• Length: 723
• Species: Danio rerio
• Alignment Length: 847
• Identity: 312/847 - (36%)
• Similarity: 463/847 - (54%)
• Gaps: 156/847 - (18%)

  Fly    16 LNAAGEAAMGAAKDVVGSVINEIFIKKEADTKRVLPSIKNMRVQPLQSQSNSTLYYGNLGEKSSS 80
            |..|....:|:.....|::.:.|..:.||        :|:.|
Zfish    14 LTEAAPQTVGSGFTAPGNIYSAILSRNEA--------VKDAR----------------------- 47

  Fly    81 LGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGY 145
                 .::|::.:.:..:....|||||||||.:.||.:|.:....:||.||.||.:||||.:.|.
Zfish    48 -----RLKDFQELRDKYVRKKVLFEDPLFPAQDSSLFYSEKFPLKLEWKRPMEICKNPQFILGGA 107

  Fly   146 SRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDR 210
            :|.|:.||:|||||||||.|.||....:..||:|.:|||.|||||||||:||:||:||||:||||
Zfish   108 NRTDICQGDLGDCWLLAAIACLTLNDVILKRVVPHDQSFTENYAGIFHFQFWRYGEWVDVVIDDR 172

  Fly   211 LPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPG 275
            ||||..:|::..|.:.|||||||:|||||||||||||||||::.||||||||||:|:|::.|||.
Zfish   173 LPTYKNKLVFTRSGQNNEFWSALMEKAYAKLHGSYEALKGGNSLEAMEDFTGGVTEFYEITEAPK 237

  Fly   276 NLFTILQKAAERNSMMGCSIEP-DPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGK----- 334
            .|:.|::||.:|.|:|||:|:. .|.....:|..||:||||||:|.|         .|||
Zfish   238 ELYNIMRKALKRGSLMGCAIDTLVPTAQRTKTASGLVRGHAYSVTGV---------EQGKRKDGK 293

  Fly   335 ---IPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRV 396
               |.::|:|:|||...    |.:..|.:|..:.:.::.:..|.....|||||.|::|..:|.::
Zfish   294 DLMIRLVRVRDPWGVAP----PPACKSNDWVELAKTEQDKQRLQPGEQGEFWMCFEEFQKNFTKL 354

  Fly   397 EICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDE 461
            |||||:||:|.:||.    .||.::::||.|..|.:|||||||.||:|.|||:.:.|::.|.  :
Zfish   355 EICNLTPDTLEDDQM----FKWNVTVHEGRWVKGCSAGGCRNFPDTYWTNPQFRLVLLEADA--K 413

  Fly   462 EGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGL--NFFRYKSSVGRSPHFI 524
            |..|||:||||||.||.:|..|.....||||||.:......|:.|.|  :||.|.:|..||..::
Zfish   414 EKTCTVVVALMQKGRRVERCSGATLHNIGFAIYEVPKEMKGNQQQQLSKDFFLYNASTARSKSYV 478

  Fly   525 NTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHV-GYGGKADTITPGFP 588
            |.|||..||.|.||.|:|:||||||::|.||::|||||.::..:..|..: ....:.|.:
Zfish   479 NIREVTERFCLKPGEYVIIPSTFDPHKESEFLLRVFSENRSTSKVIDAEIEAEPMQVDNV----- 538

  Fly   589 TPKPIDP-------QKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAF 646
             .|.|.|       :::..|.:|..|||.|||::..||:.:|:..:
Zfish   539 -KKKIKPFEEEETEEEKQFRAIFQQIAGDDMEINANELRTVLNRVV------------------- 583

  Fly   647 ETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDET 711
                                                   ..:|.|                  :|
Zfish   584 ---------------------------------------AKHKEL------------------KT 591

  Fly   712 HGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSA 776
            .|||.:.||||:|:||.|.:|.|..:||:.|.::|.:||.:|..:|.:.:..:|.|::|.||..|
Zfish   592 EGFSLESCRSMIALLDTDGTGHLNLQEFKHLWNKIKQWKLVFTRFDTDKSSTISSFEMRNALTEA 656

  Fly   777 GYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIERTI 841
            |:.|||::.:::..||.:...::.||.:|.|.|:::.....|:..|.:.:......:.||::.|:
Zfish   657 GFQLNNQLYDIICMRYANEHMELDFDSYISCLVRLEGMFRAFRAFDKDGDGLIKLNVFEWLQLTM 721

  Fly   842 YS 843
            |:
Zfish   722 YA 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	155/304 (51%)
		Calpain_III	416..569	CDD:238132	75/154 (49%)
		EFh_PEF_CalpA_B	600..843	CDD:320071	57/242 (24%)
		EF-hand motif	600..627	CDD:320071	11/26 (42%)
		EF-hand motif	717..747	CDD:320071	13/29 (45%)
		EF-hand motif	748..778	CDD:320071	10/29 (34%)
		EF-hand motif	784..812	CDD:320071	7/27 (26%)
		EF-hand motif	813..843	CDD:320071	5/29 (17%)
capn3b	NP_001230250.1	Peptidase_C2	66..358	CDD:459889	155/304 (51%)
		Calpain_III	377..514	CDD:460050	69/138 (50%)
		EFh_PEF_CAPN3	555..723	CDD:320065	57/243 (23%)
		EF-hand motif	555..583	CDD:320065	11/27 (41%)
		EF-hand motif	598..627	CDD:320065	13/28 (46%)
		EF-hand motif	628..658	CDD:320065	10/29 (34%)
		EF-hand motif	663..692	CDD:320065	7/28 (25%)
		EF-hand motif	693..723	CDD:320065	5/29 (17%)