DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hts and add3a

DIOPT Version :9

Sequence 1:	NP_001097377.2	Gene:	hts / 37230	FlyBaseID:	FBgn0263391	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_017208635.1	Gene:	add3a / 556762	ZFINID:	ZDB-GENE-030131-2721	Length:	678	Species:	Danio rerio

Alignment Length:	740	Identity:	233/740 - (31%)
Similarity:	367/740 - (49%)	Gaps:	139/740 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PPQNG-----IDPTAGEDDDNSKAR--PADIEQDMREMERRKRVEAIMGSKLFREELERIVDSAR 64
            ||..|     .|.....|.:..:||  ..|:.||...||::|||..|:.|..|::|||.::....
Zfish    15 PPSVGKREGYFDRVNENDPEYLRARNMSPDLRQDFNMMEQKKRVTQILQSPAFKDELEGMIQEQM 79

  Fly    65 DGGAGASGI--LQQLSD------IVGVPVSRVGSVFKSSNCMVPINDIRGVESMGYAKGEKILRC 121
            :.|...:|:  |:|::|      :.|...|.:     |...:.||||:..|||....||||..||
Zfish    80 NKGNNPTGLLALRQIADFFMSSSVAGFSTSPL-----SLGMVTPINDMFSVESSTMVKGEKQTRC 139

  Fly   122 KLAATFRLLDLYGWTQGLGAQITARLKVDQEYFLVNPYGLLYHEITASALNKVDMQGQIVEQGTT 186
            |||:.:|::||:.|.......||.|:..:|::.|:.|.||.:.|.:||.|.||::.|.:::||:|
Zfish   140 KLASLYRIVDLFSWAHFASCYITVRVSKEQDHILIIPRGLSFAEASASNLVKVNILGDVIDQGST 204

  Fly   187 NFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVVAISSLKTGLLPLTKDACVLGEITTHAYTGLF 251
            |...:.:.|..|:.:::.|||:||.::|......|:||:|.||||::::|.:||:|..:.|.|..
Zfish   205 NLRIDAAGFSPHAAIYSIRPDVRCIVHISTPATAAVSSMKCGLLPISQEALILGDIAYYNYQGSL 269

  Fly   252 DE-EERNRLVRSLGPNSKVILLTNHGALCCGETIEEAFFAACHIVQACETQLKLLPV--GLDNLV 313
            || |||..|.::|||.:||::|.|||.:..||||||||........|||.|:.....  |::||:
Zfish   270 DEQEERVELQKALGPTAKVLVLRNHGIVALGETIEEAFHYIYGAQYACEIQVNAFSCAGGMENLI 334

  Fly   314 LIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDGAATAEKDAAEAVPKVGSPPKWRVGGAEFEAL 378
            ::                 ||| ||.|          ..:..|:....:||..|||:|..|||:|
Zfish   335 VL-----------------DLE-KFKA----------RTQGVAQVGVNMGSQQKWRLGELEFESL 371

  Fly   379 MRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELPPAVSSLGYLLEEEE-------LFRQGIWKKG 436
            ||||||.||||||.||||::: :.|:.|::||:|..|::  ::.:|::       |.:|
Zfish   372 MRMLDNLGYRTGYTYRHPIVR-EKPRHKSEVEIPATVTA--FMFDEDDAPRFPLKLLQQ------ 427

  Fly   437 DIRKGGDRSRWLNSPNVYQKVEVLETGTPDPKKI-TKWVA--EGSPTHSTPVRIEDPLQFVPAGT 498
              |:..:::|||||||.|.||.|.:..:.:.::. |.|:.  :|.....||:|||||.||||..|
Zfish   428 --RQQREKTRWLNSPNCYMKVNVADGASEENRRTKTTWMKSDDGGNASGTPIRIEDPNQFVPLNT 490

  Fly   499 NPREFKRVQQLIKDNRRADKISAGPQSHILEGVTWDEASRLKDATVSQAGDHVVMMGAASKGIIQ 563
            ||.|..:.:..|::..|.|.::|||||..|.|                    :|:.....:..:|
Zfish   491 NPSEVLQKRNKIREQNRFDVMTAGPQSQKLAG--------------------IVVERPPGQSPVQ 535

  Fly   564 --RGFQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERKKKSVHGEYTDTDFSESEAVLQAGTKK 626
              .|.....|....|   |||..:.:.|.::.:..::..::.:..:...| .|:|.:
Zfish   536 PYMGNDEEETGALPP---NPFSELNEKEEHQRRLRIDADEEQLTSDDAST-LSQSVS-------- 588

  Fly   627 YPQSEPETEHQVIEIQTQQAPVPRQAEVVLSDDDSKNNEYGDDMENQLYER-----------NRN 680
             ||..|..|.             ....|:|:..|    ::||  |::|.:|           ..:
Zfish   589 -PQHTPAKEE-------------NHTGVMLNGKD----DHGD--EDELIKRVSQLTTSLESMEIS 633

  Fly   681 VHNNSKCRRDLFATKRRDPHPSPER 705
            |.:..|....|  |....|..||.:
Zfish   634 VRSGEKIEEAL--TPESSPSKSPNK 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hts	NP_001097377.2	Aldolase_II	116..323	CDD:238232	82/209 (39%)
add3a	XP_017208635.1	Aldolase_II	134..382	CDD:320825	107/275 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589177
Domainoid	1	1.000	193	1.000	Domainoid score	I3138
eggNOG	1	0.900	-	-		E1_COG0235
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2051
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001205
OrthoInspector	1	1.000	-	-		otm25846
orthoMCL	1	0.900	-	-		OOG6_100477
Panther	1	1.100	-	-	O	PTHR10672
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X937
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.750