DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hts and add1

DIOPT Version :9

Sequence 1:	NP_001097377.2	Gene:	hts / 37230	FlyBaseID:	FBgn0263391	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_021324516.1	Gene:	add1 / 555511	ZFINID:	ZDB-GENE-030909-2	Length:	848	Species:	Danio rerio

Alignment Length:	966	Identity:	298/966 - (30%)
Similarity:	432/966 - (44%)	Gaps:	257/966 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PPQN---------GIDPTAGEDDDNSKARPADIEQDMREMERRKRVEAIMGSKLFREELERIV-D 61
            ||.|         .:|.::.|........| |:.||...||:||||..|:.|..|.:|||.:: |
Zfish    14 PPTNPPHKERYFDRVDESSPEYQRERNMAP-DLRQDFNMMEQRKRVSMILQSPAFCDELESLIQD 77

  Fly    62 SARDGGAGASGI-LQQLSDIV---------GVPVSRVGSVFKSSNCMVPINDIRGVESMGYAKGE 116
            ..:.|....|.: |||::|.:         ..|...:.::..|...:.|:||:||.:|:.|.|||
Zfish    78 QMKKGKTPTSLLALQQIADFMTTSVPTMYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYEKGE 142

  Fly   117 KILRCKLAATFRLLDLYGWTQGLGAQITARLKVDQEYFLVNPYGLLYHEITASALNKVDMQGQIV 181
            |:|||||||.:||.||:||:|.:...:|.||..:||.||:.|:||||.|:|||:|.|:::||:||
Zfish   143 KLLRCKLAAFYRLADLFGWSQLIYNHLTVRLNSEQERFLIVPFGLLYSEVTASSLVKINLQGEIV 207

  Fly   182 EQGTTNFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVVAISSLKTGLLPLTKDACVLGEITTHA 246
            ::|:||.|.|::.|.|||.::|||||::|.::|......|:|::|.||||::.:|..|||:..|.
Zfish   208 DRGSTNLGVNQAGFTLHSAIYAARPDVKCIVHIHTPAGAAVSAMKCGLLPISPEALSLGEVAYHD 272

  Fly   247 YTGLFDEEERNRLV-RSLGPNSKVILLTNHGALCCGETIEEAFFAACHIVQACETQLKLLPV--G 308
            |.|:..:||.|.|: ::|||.|||::|.|||.:..|||:||||:...::|.|||.|::.|..  |
Zfish   273 YHGILVDEEENVLIQKNLGPKSKVLILRNHGLVSVGETVEEAFYYIHNLVTACEIQVRTLASAGG 337

  Fly   309 LDNLVLIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDGAATAEKDAAEAVPKVGSPPKWRVGGA 373
            .||||::.....|     ||  |..||       .|.||::              |.|||::|..
Zfish   338 PDNLVMLDPSKYK-----SR--PRHLE-------PAGDGSS--------------SHPKWQIGEQ 374

  Fly   374 EFEALMRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELPPAVSSLGYLLEEEELFRQGIWKKGDI 438
            |||||||||||.||||||.||.|.:: |..|..:|||:||:.:...|..:.:...|..: |....
Zfish   375 EFEALMRMLDNLGYRTGYPYRCPALR-DKTKKYSDVEIPPSATGYSYAEDSDSGARSPL-KHSFQ 437

  Fly   439 RKGGDRSRWLNSPNVYQKVEVLETGTPDPKKITK-WVAEGSPTH----------STPVRI----- 487
            |:..|::|||.:....:..|..:.|:..||..|| |.   :.||          |:.|.:
Zfish   438 RQQRDKTRWLAAGRPDESAEDGQDGSGSPKAKTKVWT---NITHDHVKPLLQSLSSGVCVPSCIT 499

  Fly   488 ------EDPL-------QFVPAGTNPREFKRVQQLIKDNRRADKISAGPQSHILEGVT------- 532
                  |:.|       ||||..|||:|.:.::..|::....||.:|||||.:|.|..
Zfish   500 NCLWTKEESLRQAAVANQFVPLNTNPKEVQEMRNKIREQNLQDKKTAGPQSQVLTGAVVDRSFVQ 564

  Fly   533 ----WDEASRLKDATVSQAG---------DHVVMMG---AASKGIIQRGFQHNATVYKAPYAKNP 581
                |.:|. |.|.|.|..|         ...:..|   .|||.||::.:|....|.|.  ..||
Zfish   565 RVTIWHDAP-LSDCTDSIDGIDPSGGFSPSRSIRKGELVTASKAIIEKEYQPRVIVSKT--GPNP 626

  Fly   582 FDNVTDDELNEYKRTVERKKKSVHGEYTDTDFSESEAVLQAGTKKYPQSEPE-------TEHQVI 639
            |:.:||.||.||::.||.|:|.          .|.||.::...     |.||       :.|:..
Zfish   627 FNKLTDQELEEYRKEVELKQKG----------GEDEAQVEDSA-----SSPEDVQGLLSSTHENP 676

  Fly   640 EIQTQQAPVPRQAEVVLSDDDSKNNEYGDDMENQLYERNRNVHNNSKCRRDLFATKRRDPHPSPE 704
            :.|...||.|.......|..||                                     |..:||
Zfish   677 DPQVIAAPPPSIIPSRASGQDS-------------------------------------PADNPE 704

  Fly   705 RLYTYVYATAASVGQCVQPEVCSALLRAL--HSEQLGYLASSYRGGAGNSNATTASTCTITSVTG 767
                           ..|.|..||:|:||  .:|..|.......|      ...:||||
Zfish   705 ---------------SPQKEFHSAVLKALGCETEAAGQPLEVEEG------KVPSSTCT------ 742

  Fly   768 SSTASRRPLQNVNIMYPQPYRTGSHFGFNSPRQQPRTEHKHVPRERDYNALGYRPMQRGISYEEI 832
                                          |...|....:.|.:|:.:.             ||.
Zfish   743 ------------------------------PPSSPVRVDEEVKQEQTFK-------------EES 764

  Fly   833 FATPRYEQLCQVCFDKLLRLKPELQRIGSGTATSSCAEEQA--STGSTPLQRRQLP 886
            .|....:.|            |:|....:..||:..:|:.|  .|.|||....:.|
Zfish   765 DAATLRQTL------------PDLTSDEASEATALPSEDPAPGQTDSTPQPEGEEP 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hts	NP_001097377.2	Aldolase_II	116..323	CDD:238232	101/209 (48%)
add1	XP_021324516.1	Aldolase_II	145..390	CDD:320825	125/272 (46%)
add1	XP_021324516.1	E3_binding	648..>815	CDD:332172	50/295 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589179
Domainoid	1	1.000	193	1.000	Domainoid score	I3138
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22758
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2051
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001205
OrthoInspector	1	1.000	-	-		otm25846
orthoMCL	1	0.900	-	-		OOG6_100477
Panther	1	1.100	-	-	LDO	PTHR10672
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R22
SonicParanoid	1	1.000	-	-		X937
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.920