DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hts and add3b

DIOPT Version :9

Sequence 1:	NP_001097377.2	Gene:	hts / 37230	FlyBaseID:	FBgn0263391	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_001189456.1	Gene:	add3b / 553243	ZFINID:	ZDB-GENE-080718-6	Length:	722	Species:	Danio rerio

Alignment Length:	783	Identity:	252/783 - (32%)
Similarity:	370/783 - (47%)	Gaps:	159/783 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTEVEQPPQNGIDPTAGEDDDNSKARP-----------------------------ADIEQDMRE 36
            |:|.|....|.||...|     .:.||                             .|:.||...
Zfish     1 MSETEIVKMNTIDEEGG-----FRTRPPSSLNVKKFYSENAEEVQSPESLRGCALSPDLRQDFNM 60

  Fly    37 MERRKRVEAIMGSKLFREELERIVDSARDGGAGASGILQQLSDIVGVPVSRVGSVFKSSN--CMV 99
            ||:||||..|:.|..|:||||.:|......|:.:||:|..::.|:...:|..| |...||  .:.
Zfish    61 MEQRKRVTQILQSPDFKEELECMVKEQSSKGSNSSGLLGHIAHIISNTLSNTG-VHSPSNTGSIS 124

  Fly   100 PINDIRGVESMGYAKGEKILRCKLAATFRLLDLYGWTQGLGAQITARLKVDQEYFLVNPYGLLYH 164
            |:||:.|:|....:|.|:..|||||..:|||||||.|......||.|:..:|::.|:.|.||.:.
Zfish   125 PVNDLCGMEWFNCSKAERQGRCKLACLYRLLDLYGHTHLPNTYITLRINKEQDHILILPKGLSFS 189

  Fly   165 EITASALNKVDMQGQIVEQGTTNFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVVAISSLKTGL 229
            |.||::|.||::.|::|:||.|....:...|..||.:::||||.:|.::.......|:||:|.|:
Zfish   190 EATAASLVKVNLIGEVVDQGATALPVDVLGFKPHSAIYSARPDAKCVVHTYTPNTAAVSSMKCGI 254

  Fly   230 LPLTKDACVLGEITTHAYTG-LFDEEERNRLVRSLGPNSKVILLTNHGALCCGETIEEAFFAACH 293
            ||:|.:|.:|||::..:|.| |.||:|:..|.::|||.:||::|.|.|.|..||||||||....|
Zfish   255 LPITHEALLLGEVSYFSYHGDLADEQEKMELQKALGPTAKVLVLRNQGLLAFGETIEEAFHYLYH 319

  Fly   294 IVQACETQLK--LLPVGLDNLVLIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDGAATAEKDAA 356
            ..||||.|:.  |...|::||.::...|.|                                 .|
Zfish   320 CHQACEIQVSAVLSAGGVNNLCVLDRASLK---------------------------------TA 351

  Fly   357 EAVPKVGSPP----KWRVGGAEFEALMRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELPPAVSS 417
            .|....|..|    :||||.||||:|||||||.||||||.||||::| :.|:..||||:|..|:
Zfish   352 PAKNPGGQMPDGQIRWRVGEAEFESLMRMLDNLGYRTGYTYRHPIVK-EKPRHHNDVEIPATVT- 414

  Fly   418 LGYLLEEEELFRQG----IWKKGDIRKGGDRSRWLNSPNVYQKVEVLE---TGTPDPKKITKWV- 474
             |..|||::.|...    :.:|.|    .:|.|||||||.|.||:|.|   .||..|:..|.|:
Zfish   415 -GMALEEKDTFPHSPLHILGQKRD----RERIRWLNSPNSYLKVDVPEESFNGTCSPRTKTTWLK 474

  Fly   475 -AEGSPTHSTPVRIEDPLQFVPAGTNPREFKRVQQLIKDNRRADKISAGPQSHILEGVTWDEASR 538
             .|......||::||||.||||..|||.|....:..|::..|||.::|||:|.:|..:..|:..
Zfish   475 SEESGSCKDTPIKIEDPNQFVPLNTNPTEVLEKRNKIREQNRADLMTAGPKSQLLADIVIDKPP- 538

  Fly   539 LKDATVSQAGDHVVMMGAASKGIIQRGFQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERK-KK 602
                            |.|        |.:......|....||||. ::.:|..|.:|||.| .:
Zfish   539 ----------------GPA--------FIYEDEEKTAALPPNPFDQ-SEADLQAYTQTVENKNSQ 578

  Fly   603 SVHGEYTDTDFSESEAVLQAGT----KKYPQSEPE-----------------TEHQVIEIQTQQA 646
            |......|.:|::.|.....|:    ...|...||                 |:.:.:.:|..:.
Zfish   579 SALQSEADEEFTDGEMTTYDGSTISLSISPLMSPERGDCLSALLQSSDGDDLTQDEDLTLQVTEL 643

  Fly   647 PVPRQAEVVLSDDDSKNNEYGDDMENQLYERNRNVHNNSKCRRDLFAT----------KRRDPHP 701
            .:.::.:|.::...:.|.......|:|        ..:.|.::..|.|          :||:...
Zfish   644 SLTKEMQVSITTTVANNISVTSSSESQ--------QKSPKKKKKKFRTPSFLRMSKKKERREKEK 700

  Fly   702 SPE 704
            :.|
Zfish   701 TTE 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hts	NP_001097377.2	Aldolase_II	116..323	CDD:238232	89/209 (43%)
add3b	NP_001189456.1	Aldolase_II	137..388	CDD:294146	111/283 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589178
Domainoid	1	1.000	193	1.000	Domainoid score	I3138
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2051
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001205
OrthoInspector	1	1.000	-	-		otm25846
orthoMCL	1	0.900	-	-		OOG6_100477
Panther	1	1.100	-	-	O	PTHR10672
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X937
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.890