DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hts and add1

DIOPT Version :9

Sequence 1:	NP_001097377.2	Gene:	hts / 37230	FlyBaseID:	FBgn0263391	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_017947468.1	Gene:	add1 / 448173	XenbaseID:	XB-GENE-995030	Length:	913	Species:	Xenopus tropicalis

Alignment Length:	839	Identity:	277/839 - (33%)
Similarity:	405/839 - (48%)	Gaps:	202/839 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PPQNGIDPTAGE------DDDN-----SKARPADIEQDMREMERRKRVEAIMGSKLFREELERIV 60
            ||.|   |...|      |::|     .:....|:.||...||::|||..|:.|..|.:|||.::
Frog    14 PPTN---PPHKEKYFDRVDENNPEYLRERNMAPDLRQDFNMMEQKKRVSMILQSPAFCDELESLI 75

  Fly    61 DSARDGGAGASGI--LQQLSDIV--GVPVSRVGSVFKSS------------NCMVPINDIRGVES 109
            ......|...:|:  |||::|.:  |||     :|:.|:            ..:.|:||:||.:|
Frog    76 QDQLKKGKNPTGLLALQQIADFMTTGVP-----NVYPSAPQGGMAALNLSLGMVTPVNDLRGSDS 135

  Fly   110 MGYAKGEKILRCKLAATFRLLDLYGWTQGLGAQITARLKVDQEYFLVNPYGLLYHEITASALNKV 174
            :.|.||||:|||||||..||.||:||:|.:...||.|:..:||:||:.|:||||.|:|||:|.||
Frog   136 IAYEKGEKLLRCKLAAFHRLADLFGWSQLIYNHITVRVNSEQEHFLIVPFGLLYSEVTASSLIKV 200

  Fly   175 DMQGQIVEQGTTNFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVVAISSLKTGLLPLTKDACVL 239
            ::||::|::|:||.|.||:.|.|||.::|||||::|.::|......|:|::|.|||||:.:|..|
Frog   201 NLQGELVDRGSTNLGVNKAGFTLHSAIYAARPDVKCIVHIHSPAGAAVSAMKCGLLPLSPEALSL 265

  Fly   240 GEITTHAYTG-LFDEEERNRLVRSLGPNSKVILLTNHGALCCGETIEEAFFAACHIVQACETQLK 303
            ||:..|.|.| |.||||:..:.::|||.|||::|.|||.:..|||:||||:...:::.|||.|::
Frog   266 GEVAYHDYHGILVDEEEKVLIQKNLGPKSKVLILRNHGLVTMGETVEEAFYYIHNLMSACEIQVR 330

  Fly   304 LLPV--GLDNLVLIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDGAATAEKDAAEAVPKVGSPP 366
            .|..  |.|||||:....    |::||.|.          ..:.||:              |..|
Frog   331 TLASAGGPDNLVLLDPGK----YKKSRSPE----------TPSGDGS--------------GLHP 367

  Fly   367 KWRVGGAEFEALMRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELPPAVSSLGYLLEEE------ 425
            ||.||..|||||||||||.||||||.||.|.:: :..|..:|||:|.:|:  ||.|..:
Frog   368 KWLVGEQEFEALMRMLDNLGYRTGYPYRCPALR-EKAKKYSDVEIPASVT--GYSLGNDGGSGTC 429

  Fly   426 ELFRQGIWKKGDIRKGGDRSRWLN---------------SPNVYQKV-------------EVLET 462
            ...|....|     :..::::|||               ||....||             :.|.:
Frog   430 SPLRHSFQK-----QQREKTKWLNSGRADDTSEDGQNGGSPKSKTKVWTNITHDHVKPLLQSLSS 489

  Fly   463 GTPDPKKITK--WVAE-GSPTHSTPVRIEDPLQFVPAGTNPREFKRVQQLIKDNRRADKISAGPQ 524
            |...|..||.  |..| |..:.::.|    |..|||..|:|:|.:.::..|::....|..:||||
Frog   490 GVCVPSCITNCLWTKEDGMKSATSAV----PNMFVPLNTDPKEVQEMRNKIREQNLQDIKTAGPQ 550

  Fly   525 SHILEGVTWDEA--SRL---KDATVSQAGDHV-----------------VMMG---AASKGIIQR 564
            |.:|.||..|.:  .||   |||.:|...:.:                 |..|   .|||.||::
Frog   551 SQVLCGVVVDRSVVQRLAVYKDAPLSDCSETIEGLDLTEQTFSPAKTLSVRKGELVTASKAIIEK 615

  Fly   565 GFQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERKKKSVH--GEYTDTDFSESEAVLQAGTKKY 627
            .:|....|...  ..|||:..:|.||.||.:.:|||:|...  ||...:..|....||   :...
Frog   616 EYQPKVIVTST--GPNPFNKFSDRELEEYHKEIERKQKGAEDCGETAVSPSSLEGVVL---STHG 675

  Fly   628 PQSEPETEHQVIEIQTQQAPVPRQAEVVLSDDDSKNNEYGDDMENQLYERNRNVHNNSKCRRDLF 692
            |..|               ||..|:|.                     |||..:|.:      |.
Frog   676 PNGE---------------PVSSQSEA---------------------ERNEQIHTS------LA 698

  Fly   693 ATKRRDPHPSPERLYTYVYATAASV----GQCVQPEVCSALLRALH---------SEQL 738
            .....:|..:||..::.:..|...:    |.....|..:|::|||:         :|||
Frog   699 EVNGEEPRAAPEHHHSELPVTGVLIAEENGLSPHKEFHTAVIRALNFSSDFIPSTTEQL 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hts	NP_001097377.2	Aldolase_II	116..323	CDD:238232	103/209 (49%)
add1	XP_017947468.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3112
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22758
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2103
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001205
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10672
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R22
SonicParanoid	1	1.000	-	-		X937
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090