DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hts and add-1

DIOPT Version :9

Sequence 1:	NP_001097377.2	Gene:	hts / 37230	FlyBaseID:	FBgn0263391	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_001024640.1	Gene:	add-1 / 180760	WormBaseID:	WBGene00000072	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	804	Identity:	290/804 - (36%)
Similarity:	416/804 - (51%)	Gaps:	147/804 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EVEQPPQNGIDPTAGEDDDNSK--ARPADIEQDMREMERRKRVEAIMGSKLFREELERIV----D 61
            |.|:|...  ||   :|.:..|  .|||.|::|:.||||||||:.|:.||.|..|||.::    |
Worm     8 ERERPYYR--DP---DDPEYIKDLQRPAVIKEDLSEMERRKRVQQILESKSFCHELEEVIRQECD 67

  Fly    62 SARDGGAGASGILQQLSDIVGVPVSRV--GSVFKSSNCMVPINDIRGVESMGYAKGEKILRCKLA 124
            :||....... :||:|||:. ||...:  |::.......:.|.|:||.|.  |:|.|:|.|.|||
Worm    68 TARTDPDHLQ-VLQKLSDLT-VPQGNMSFGNLHTYGGNTIAIADLRGNEK--YSKAERIQRNKLA 128

  Fly   125 ATFRLLDLYGWTQGLGAQITARLKVDQEYFLVNPYGLLYHEITASALNKVDMQGQIVEQGTTNFG 189
            ..|||.||:.|:||:..:|:.|...:...||:||:|||||||||:.:.|:|..|:|::.||...|
Worm   129 CLFRLADLFQWSQGIHNEISYRTNDEDNTFLMNPFGLLYHEITAATIVKIDENGKILDCGTLKAG 193

  Fly   190 GNKSHFVLHSVVHAARPDIRCAIYIGCSPVVAISSLKTGLLPLTKDACVLGEITTHAYTGLFDEE 254
            .|:..|:|||.::.|.|.:||.:::..:.|.|::|:|.|||||.|:|.|||.:..|.|..:.|::
Worm   194 VNQPAFLLHSAIYKAHPMVRCILHMHTAIVAAVASMKCGLLPLCKEAMVLGPVGYHDYQDIGDDD 258

  Fly   255 -ERNRLVRSLGPNSKVILLTNHGALCCGETIEEAFFAACHIVQACETQLKLLPVGLDNLVLIPEE 318
             :.:.::.:|| :..|:.|.|.|.|..|:|||.|.|.|.:.|.|||||::....|||||: ||||
Worm   259 IQFDEIIANLG-DKNVLFLRNQGFLVVGDTIEHATFLANNTVIACETQVRAARAGLDNLI-IPEE 321

  Fly   319 SRKAIYEQSR--RPPEDLEKKFAAVAAAEDGAATAEKDAAEAVPKVGSPPKWRVGGAEFEALMRM 381
              |||....|  |....|::.           .|.:               ||||..|:|:.||:
Worm   322 --KAIQRAFRNSRNTNSLKRN-----------GTVD---------------WRVGELEWESWMRV 358

  Fly   382 LDNAGYRTGYIYRHPLIKSDPPKP--------KNDVELPPAVSSLGYLLEEEELFRQGIWKKGDI 438
            ||:|.::||::||.|.::   ||.        .|||.:||..|:.|. ::|..|......:...:
Worm   359 LDHANFQTGHVYRQPQLR---PKSAMSTSMVNNNDVAVPPTTSAYGQ-IDETNLESVSAHRLALL 419

  Fly   439 RKGGDRSRWLNSPNVYQKVEVLETGTPDPKKITKWVAE-GSPTHS-TPVRIEDPLQFVPAGTNPR 501
            ||..:|.||:||||.|||||.||.|..:||||||||.: ..|:.| |||:|....||.||.:||:
Worm   420 RKEQERVRWMNSPNAYQKVEFLEYGADNPKKITKWVHDVNVPSASGTPVKISSVHQFSPASSNPK 484

  Fly   502 EFKRVQQLIKDNRRADKISAGPQSHILEGVTWDEASRL----KDATVSQA--GDHVVMMGAASKG 560
            |||..|:.||:|.|...:||||||.||:.||:::.:.|    .|.||.|:  .|..:::|.||||
Worm   485 EFKEKQKAIKENNRLGTLSAGPQSQILDSVTYEDIALLIKPDNDGTVGQSSTADRAILIGTASKG 549

  Fly   561 IIQRGFQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERKKKSVHGEYTDTDFSESEAV-LQAGT 624
            ||.|.|||:|.||...||.|||...||.::.:|...|:.|.            |:|..| .::|.
Worm   550 IIDRQFQHHAQVYHQIYAPNPFSVETDADIKKYVDMVKAKN------------SQSAPVSARSGY 602

  Fly   625 KKYPQSEPET--------EHQVIEIQTQQAPVPRQAEVVLSDDD-----SKNN-EYGDDMENQLY 675
            .:|.:.|.:|        ||::           .||.:..|||.     |.|| ...::..|..|
Worm   603 SQYDEVEADTVSLMQGVREHKL-----------SQAALSASDDGLNAGISPNNVRTSEESVNTSY 656

  Fly   676 ERNRNVHNNSKCRRDLFATKRRDPHPSPERLYTYVYATAASVGQCVQPEVCSALLRALHSEQLGY 740
            .....|.:   |           .||||..:.|.                        :.|::..
Worm   657 MSQSVVFD---C-----------DHPSPMSISTE------------------------YPEKVKM 683

  Fly   741 LASSYRGGAGNSNATTASTCTITS 764
            ...|...|....| ||:.:||..|
Worm   684 TRFSSTQGTSEGN-TTSRSCTTAS 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hts	NP_001097377.2	Aldolase_II	116..323	CDD:238232	92/207 (44%)
add-1	NP_001024640.1	Aldolase_II	115..360	CDD:294146	108/276 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I2176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22758
Inparanoid	1	1.050	397	1.000	Inparanoid score	I1109
Isobase	1	0.950	-	0	Normalized mean entropy	S5158
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001205
OrthoInspector	1	1.000	-	-		oto18170
orthoMCL	1	0.900	-	-		OOG6_100477
Panther	1	1.100	-	-	LDO	PTHR10672
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X937
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.910