DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hts and ADD3

DIOPT Version :9

Sequence 1:NP_001097377.2 Gene:hts / 37230 FlyBaseID:FBgn0263391 Length:1833 Species:Drosophila melanogaster
Sequence 2:NP_001307520.1 Gene:ADD3 / 120 HGNCID:245 Length:706 Species:Homo sapiens


Alignment Length:695 Identity:246/695 - (35%)
Similarity:370/695 - (53%) Gaps:87/695 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 DIEQDMREMERRKRVEAIMGSKLFREELERIVDSARDGGAGASGI--LQQLSD-IVGVPVSRVGS 90
            |:.||...||:||||..|:.|..|||:||.::......|...:|:  |||::| |:....|...|
Human    44 DLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLALQQIADYIMANSFSGFSS 108

  Fly    91 VFKSSNCMVPINDIRGVESMGYAKGEKILRCKLAATFRLLDLYGWTQGLGAQITARLKVDQEYFL 155
            ...|...:.||||:.|.::..|.||||:.|||||:.:||:||:||.......|:.|:..:|::.:
Human   109 PPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHII 173

  Fly   156 VNPYGLLYHEITASALNKVDMQGQIVEQGTTNFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVV 220
            :.|.||.:.|.|||.|.||::.|::|:||:||...:.:.|..|:.:::.|||::|.|:|......
Human   174 IIPRGLSFSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATA 238

  Fly   221 AISSLKTGLLPLTKDACVLGEITTHAYTG-LFDEEERNRLVRSLGPNSKVILLTNHGALCCGETI 284
            |:||:|.|:||:::::.:||::..:.|.| |.::|||.:|.:.|||:.||::|.|||.:..|||:
Human   239 AVSSMKCGILPISQESLLLGDVAYYDYQGSLEEQEERIQLQKVLGPSCKVLVLRNHGVVALGETL 303

  Fly   285 EEAFFAACHIVQACETQLKLL--PVGLDNLVLIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDG 347
            ||||....::..|||.|::.|  ..|:|||.::..:..||               |....||..|
Human   304 EEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKA---------------FTYTVAASGG 353

  Fly   348 AATAEKDAAEAVPKVGSPPKWRVGGAEFEALMRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELP 412
            ...          .:||..||:||..|||.|||.|||.||||||.||||||: :.|:.|:|||:|
Human   354 GGV----------NMGSHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIR-EKPRHKSDVEIP 407

  Fly   413 PAVSSLGYLLEEEELFRQGIWKKGDIRKGGDRSRWLNSPNVYQKVEVLE---TGTPDPK-KITKW 473
            ..|::..:   |::.......|....|:..:::|||||||.|.||.|.|   .|...|: |||..
Human   408 ATVTAFSF---EDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWM 469

  Fly   474 VAEGSPTHS--TPVRIEDPLQFVPAGTNPREFKRVQQLIKDNRRADKISAGPQSHILEGVTWDEA 536
            .||.|...|  ||::||||.||||..|||.|....:..|::..|.|..:|||||.:|.|:..|  
Human   470 KAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVD-- 532

  Fly   537 SRLKDATVSQAGDHVVMMGAASKGIIQRGFQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERKK 601
               |..:..|..|.                .|.     .|...|||.::|:.||.|||||:|||:
Human   533 ---KPPSTMQFEDD----------------DHG-----PPAPPNPFSHLTEGELEEYKRTIERKQ 573

  Fly   602 KSVHGEYTD--TDFSESEAVLQAGTKKYPQSEP---ETEHQVIEIQTQQAPVPRQAEVVLSDDDS 661
            :.:.....:  :|.:.|.:.:|:.|:. ||:.|   |..|::.........||  ..||...||.
Human   574 QGLEDAEQELLSDDASSVSQIQSQTQS-PQNVPEKLEENHELFSKSFISMEVP--VMVVNGKDDM 635

  Fly   662 KNNEYGDDMENQLYERNRNVHNNSKCRRDLFATKRRDPHPSPERL 706
                  .|:|::|.:|...:..::.........|      |||::
Human   636 ------HDVEDELAKRVSRLSTSTTIENIEITIK------SPEKI 668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htsNP_001097377.2 Aldolase_II 116..323 CDD:238232 82/209 (39%)
ADD3NP_001307520.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Aldolase_II 137..385 CDD:320825 102/272 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 471..497 14/25 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 535..555 6/40 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 575..610 7/35 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 666..706 1/3 (33%)
Interaction with calmodulin. /evidence=ECO:0000255 684..701
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154053
Domainoid 1 1.000 192 1.000 Domainoid score I3218
eggNOG 1 0.900 - - E1_COG0235
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 384 1.000 Inparanoid score I2048
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001205
OrthoInspector 1 1.000 - - otm41996
orthoMCL 1 0.900 - - OOG6_100477
Panther 1 1.100 - - O PTHR10672
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X937
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.750

Return to query results.
Submit another query.