DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hts and ADD2

DIOPT Version :9

Sequence 1:NP_001097377.2 Gene:hts / 37230 FlyBaseID:FBgn0263391 Length:1833 Species:Drosophila melanogaster
Sequence 2:NP_001171983.1 Gene:ADD2 / 119 HGNCID:244 Length:726 Species:Homo sapiens


Alignment Length:771 Identity:260/771 - (33%)
Similarity:392/771 - (50%) Gaps:146/771 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 EVEQPPQNGIDPTAG--------EDDD---NSKARPADIEQDMREMERRKRVEAIMGSKLFREEL 56
            |...||     |..|        |||.   ..:.|.||:.||...||::|||..|:.|..|||||
Human     8 EAASPP-----PPQGQPYFDRFSEDDPEYMRLRNRAADLRQDFNLMEQKKRVTMILQSPSFREEL 67

  Fly    57 ERIVDSARDGGAGASGI--LQQLSDIVGVPVSRVGSVFKSS----NCMVPINDIRGVESMGYAKG 115
            |.::......|..:|.|  |:|::|.:   .|...:||.:|    :.|.||||:...:|:..|||
Human    68 EGLIQEQMKKGNNSSNIWALRQIADFM---ASTSHAVFPTSSMNVSMMTPINDLHTADSLNLAKG 129

  Fly   116 EKILRCKLAATFRLLDLYGWTQGLGAQITARLKVDQEYFLVNPYGLLYHEITASALNKVDMQGQI 180
            |:::|||:::.:||||||||.|.....:|.|:..:|::||::|.|:...|:|||:|.||::.|::
Human   130 ERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNILGEV 194

  Fly   181 VEQGTTNFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVVAISSLKTGLLPLTKDACVLGEITTH 245
            ||:|::.|..:.:.|.|||.::|||||:||.|::......|:|::|.||||::.:|.::|::..:
Human   195 VEKGSSCFPVDTTGFCLHSAIYAARPDVRCIIHLHTPATAAVSAMKWGLLPVSHNALLVGDMAYY 259

  Fly   246 AYTGLFDEE-ERNRLVRSLGPNSKVILLTNHGALCCGETIEEAFFAACHIVQACETQLKLLPV-- 307
            .:.|..::| :|..|.:.|||..|:::|.|||.:..|:|:||||:...|:..|||.|:..|..  
Human   260 DFNGEMEQEADRINLQKCLGPTCKILVLRNHGVVALGDTVEEAFYKIFHLQAACEIQVSALSSAG 324

  Fly   308 GLDNLVLIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDGAATAEKDAAEAVPKVGSPPKWRVGG 372
            |::||:|:.:|        ..||.|        |.:.:...:|           .|...|.|:|.
Human   325 GVENLILLEQE--------KHRPHE--------VGSVQWAGST-----------FGPMQKSRLGE 362

  Fly   373 AEFEALMRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELPPAVSSLGYLLEEE----ELFRQGIW 433
            .|||||||||||.||||||.||||.:: :..|.|::||:|..|::  ::.||:    ...||...
Human   363 HEFEALMRMLDNLGYRTGYTYRHPFVQ-EKTKHKSEVEIPATVTA--FVFEEDGAPVPALRQHAQ 424

  Fly   434 KKGDIRKGGDRSRWLNSPNVYQKVEVLE-----TGTPDPKKITKWVAEGSPTHST---PVRIEDP 490
            |:..     :::||||:||.|.:|.|.:     .|:|.||  |.|:.......|:   |:|||:|
Human   425 KQQK-----EKTRWLNTPNTYLRVNVADEVQRSMGSPRPK--TTWMKADEVEKSSSGMPIRIENP 482

  Fly   491 LQFVPAGTNPREFKRVQQLIKDNRRADKISAGPQSHILEGVTWDEASRLKDATVSQAGDHVVMMG 555
            .||||..|:|:|...::..|::..|.|..||||||.:|..|. .|.|| ..:|.||         
Human   483 NQFVPLYTDPQEVLEMRNKIREQNRQDVKSAGPQSQLLASVI-AEKSR-SPSTESQ--------- 536

  Fly   556 AASKGIIQRGFQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERKKKSVHGE------------- 607
            ..|||..........||      .|||..:||.||.|||:.|||||..:.||             
Human   537 LMSKGDEDTKDDSEETV------PNPFSQLTDQELEEYKKEVERKKLELDGEKETAPEEPGSPAK 595

  Fly   608 --------------YTDTDFSESEAVLQAGTKKYPQS-----EPET---EHQVIEIQTQQAPVPR 650
                          .|.:........|:.||||...|     ||||   |..|:..:.::    :
Human   596 SAPASPVQSPAKEAETKSPLVSPSKSLEEGTKKTETSKAATTEPETTQPEGVVVNGREEE----Q 656

  Fly   651 QAEVVLSDDDSKNNEYGD-DMENQLYERNRNVHNNSKCRRDLFATKRRDPHPSPER 705
            .||.:||...|:.....| |::            .||.:.:...:....|..||.:
Human   657 TAEEILSKGLSQMTTSADTDVD------------TSKDKTESVTSGPMSPEGSPSK 700

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htsNP_001097377.2 Aldolase_II 116..323 CDD:238232 82/209 (39%)
ADD2NP_001171983.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25 5/21 (24%)
Aldolase_II 130..379 CDD:381867 104/275 (38%)
Interaction with calmodulin. /evidence=ECO:0000255 425..444 8/23 (35%)
PRK13108 <509..647 CDD:237284 49/154 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..726 53/208 (25%)
Interaction with calmodulin. /evidence=ECO:0000255 704..721
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154055
Domainoid 1 1.000 192 1.000 Domainoid score I3218
eggNOG 1 0.900 - - E1_COG0235
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 384 1.000 Inparanoid score I2048
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001205
OrthoInspector 1 1.000 - - otm41996
orthoMCL 1 0.900 - - OOG6_100477
Panther 1 1.100 - - O PTHR10672
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X937
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.750

Return to query results.
Submit another query.