DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hts and ADD1

DIOPT Version :9

Sequence 1:	NP_001097377.2	Gene:	hts / 37230	FlyBaseID:	FBgn0263391	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_001341690.1	Gene:	ADD1 / 118	HGNCID:	243	Length:	799	Species:	Homo sapiens

Alignment Length:	805	Identity:	269/805 - (33%)
Similarity:	393/805 - (48%)	Gaps:	172/805 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEQPPQNGIDPTAGE---------DDDN-----SKARPADIEQDMREMERRKRVEAIMGSKLFRE 54
            |..||     ||...         |::|     .:....|:.||...||::|||..|:.|..|.|
Human    10 VTSPP-----PTTAPHKERYFDRVDENNPEYLRERNMAPDLRQDFNMMEQKKRVSMILQSPAFCE 69

  Fly    55 ELERIVDSARDGGAGASGI--LQQLSDIV---------GVPVSRVGSVFKSSNCMVPINDIRGVE 108
            |||.::......|...:|:  |||::|.:         ..|...:.::..|...:.|:||:||.:
Human    70 ELESMIQEQFKKGKNPTGLLALQQIADFMTTNVPNVYPAAPQGGMAALNMSLGMVTPVNDLRGSD 134

  Fly   109 SMGYAKGEKILRCKLAATFRLLDLYGWTQGLGAQITARLKVDQEYFLVNPYGLLYHEITASALNK 173
            |:.|.||||:|||||||.:||.||:||:|.:...||.|:..:||:||:.|:||||.|:|||:|.|
Human   135 SIAYDKGEKLLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVK 199

  Fly   174 VDMQGQIVEQGTTNFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVVAISSLKTGLLPLTKDACV 238
            :::||.||::|:||.|.|::.|.|||.::|||||::|.::|......|:|::|.||||::.:|..
Human   200 INLQGDIVDRGSTNLGVNQAGFTLHSAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALS 264

  Fly   239 LGEITTHAYTG-LFDEEERNRLVRSLGPNSKVILLTNHGALCCGETIEEAFFAACHIVQACETQL 302
            |||:..|.|.| |.||||:..:.::|||.|||::|.|||.:..||::||||:...::|.|||.|:
Human   265 LGEVAYHDYHGILVDEEEKVLIQKNLGPKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQV 329

  Fly   303 KLLPV--GLDNLVLIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDGAATAEKDAAEAVPKVGSP 365
            :.|..  |.|||||:..|..||   :||.|                |:...|        ..|||
Human   330 RTLASAGGPDNLVLLNPEKYKA---KSRSP----------------GSPVGE--------GTGSP 367

  Fly   366 PKWRVGGAEFEALMRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELPPAVSSLGYLLEEEELFRQ 430
            |||::|..|||||||||||.||||||.||:|.:: :..|..:|||:|.:|:  ||....:
Human   368 PKWQIGEQEFEALMRMLDNLGYRTGYPYRYPALR-EKSKKYSDVEVPASVT--GYSFASD----- 424

  Fly   431 GIWKKGDI-----------RKGGDRSRWLN---------------SPNVYQKV------------ 457
                 ||.           ::..:::||||               ||....||
Human   425 -----GDSGTCSPLRHSFQKQQREKTRWLNSGRGDEASEEGQNGSSPKSKTKVWTNITHDHVKPL 484

  Fly   458 -EVLETGTPDPKKITK--WVAE-GSPTHSTPVRIEDPLQFVPAGTNPREFKRVQQLIKDNRRADK 518
             :.|.:|...|..||.  |..| |..|.::.|    |..|||..|||:|.:.::..|::....|.
Human   485 LQSLSSGVCVPSCITNCLWTKEDGHRTSTSAV----PNLFVPLNTNPKEVQEMRNKIREQNLQDI 545

  Fly   519 ISAGPQSHILEGVTWD----------------EASRLKDATVSQAGDHVVMMG---AASKGIIQR 564
            .:|||||.:|.||..|                |...|.:.|.|.|.......|   .|||.||::
Human   546 KTAGPQSQVLCGVVMDRSLVQDAPLSDCTETIEGLELTEQTFSPAKSLSFRKGELVTASKAIIEK 610

  Fly   565 GFQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERKKKSVHGEYTDTDFSESEAVLQAGTKKYPQ 629
            .:|.:..|  :....|||..:||.||.||:|.||||:|   |...:.|.:..:      .:|.|.
Human   611 EYQPHVIV--STTGPNPFTTLTDRELEEYRREVERKQK---GSEENLDEAREQ------KEKSPP 664

  Fly   630 SEPETEH----QVIEIQTQQAPVPRQAEVVLSDD-----------DSKNNEYGDDMENQLYERNR 679
            .:|...|    ..|:::....|.|     ...||           |...:|..:.:...:.|:..
Human   665 DQPAVPHPPPSTPIKLEEDLVPEP-----TTGDDSDAATFKPTLPDLSPDEPSEALGFPMLEKEE 724

  Fly   680 NVHNNSKCRRDLFATKRRDPHPSPE 704
            ..|.......   |.....|.|:|:
Human   725 EAHRPPSPTE---APTEASPEPAPD 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hts	NP_001097377.2	Aldolase_II	116..323	CDD:238232	103/209 (49%)
ADD1	NP_001341690.1	Aldolase_II	145..391	CDD:320825	127/272 (47%)
ADD1	NP_001341690.1	BASP1	<646..764	CDD:330577	20/118 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154054
Domainoid	1	1.000	192	1.000	Domainoid score	I3218
eggNOG	1	0.900	-	-		E1_COG0235
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22758
Inparanoid	1	1.050	384	1.000	Inparanoid score	I2048
Isobase	1	0.950	-	0	Normalized mean entropy	S5158
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001205
OrthoInspector	1	1.000	-	-		otm41996
orthoMCL	1	0.900	-	-		OOG6_100477
Panther	1	1.100	-	-	LDO	PTHR10672
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R22
SonicParanoid	1	1.000	-	-		X937
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.730