DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hts and Add2

DIOPT Version :9

Sequence 1:	NP_001097377.2	Gene:	hts / 37230	FlyBaseID:	FBgn0263391	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_001258786.1	Gene:	Add2 / 11519	MGIID:	87919	Length:	725	Species:	Mus musculus

Alignment Length:	752	Identity:	259/752 - (34%)
Similarity:	394/752 - (52%)	Gaps:	115/752 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EVEQPPQNGIDPTAG--------EDDD---NSKARPADIEQDMREMERRKRVEAIMGSKLFREEL 56
            |...||     |:.|        |||.   ..:.|.||:.||...||::|||..|:.|..|||||
Mouse     8 EAASPP-----PSQGQHYFDRFSEDDPEYLRLRNRAADLRQDFNLMEQKKRVTMILQSPSFREEL 67

  Fly    57 ERIVDSARDGGAGASGI--LQQLSDIVGVPVSRVGSVFKSS----NCMVPINDIRGVESMGYAKG 115
            |.::......|..:|.|  |:|::|.:   .|...:||.:|    :.|.||||:...:|:..|||
Mouse    68 EGLIQEQMKKGNNSSNIWALRQIADFM---ASTSHAVFPASSMNFSMMTPINDLHTADSLNLAKG 129

  Fly   116 EKILRCKLAATFRLLDLYGWTQGLGAQITARLKVDQEYFLVNPYGLLYHEITASALNKVDMQGQI 180
            |:::|||:::.:||||||||.|.....:|.|:..:|::||::|.|:...|:|||:|.||::.|::
Mouse   130 ERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNILGEV 194

  Fly   181 VEQGTTNFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVVAISSLKTGLLPLTKDACVLGEITTH 245
            ||:|::.|..:.:.|.|||.::|||||:||||::......|:|::|.||||::.:|.::|::..:
Mouse   195 VEKGSSCFPVDTTGFSLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHNALLVGDMAYY 259

  Fly   246 AYTGLFDEE-ERNRLVRSLGPNSKVILLTNHGALCCGETIEEAFFAACHIVQACETQLKLLPV-- 307
            .:.|..::| :|..|.:.|||..|:::|.|||.:..|:|:||||:...|:..|||.|:..|..
Mouse   260 DFNGEMEQEADRINLQKCLGPTCKILVLRNHGMVALGDTVEEAFYKVFHLQAACEVQVSALSSAG 324

  Fly   308 GLDNLVLIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDGAATAEKDAAEAVPKVGSPPKWRVGG 372
            |.:||:|:.:|        ..||.|        |.:.:...:|           .|...|.|:|.
Mouse   325 GTENLILLEQE--------KHRPHE--------VGSVQWAGST-----------FGPMQKSRLGE 362

  Fly   373 AEFEALMRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELPPAVSSLGYLLEEEEL----FRQGIW 433
            .|||||||||||.||||||.||||.:: :..|.|::||:|..|::  ::.||:.:    .||...
Mouse   363 HEFEALMRMLDNLGYRTGYTYRHPFVQ-EKTKHKSEVEIPATVTA--FVFEEDGVPVPALRQHAQ 424

  Fly   434 KKGDIRKGGDRSRWLNSPNVYQKVEVLE-----TGTPDPKKITKWVAEGSPTHST---PVRIEDP 490
            |:..     :::||||:||.|.:|.|.:     .|:|.||  |.|:.......|:   |:|||:|
Mouse   425 KQQK-----EKTRWLNTPNTYLRVNVADEVQRNMGSPRPK--TTWMKADEVEKSSSGMPIRIENP 482

  Fly   491 LQFVPAGTNPREFKRVQQLIKDNRRADKISAGPQSHILEGVTWDEASRLKDATVSQAGDHVVMMG 555
            .||||..|:|:|...::..|::..|.|..||||||.:|..|. .|.|| ..:|.||
Mouse   483 NQFVPLYTDPQEVLDMRNKIREQNRQDIKSAGPQSQLLASVI-AEKSR-SPSTESQ--------- 536

  Fly   556 AASKGIIQRGFQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERKK--KSVHGE----------- 607
            ..|||......:...||      .|||..:||.||.|||:.|||||  :...||
Mouse   537 LMSKGDADTKDESEETV------PNPFSQLTDQELEEYKKEVERKKLEQEQEGEKDIATEKPGSP 595

  Fly   608 YTDTDFSESEAVLQAGTKKYPQSEPETEH-----QVIEIQTQQAPVPRQAEVVLSDDDSKNNEYG 667
            ...|..|..::..:||||....|..:|..     :|.|..|:..||..:..||...::..:.|
Mouse   596 VKSTPASPVQSPSKAGTKSPAVSPSKTSEDTKKTEVSEANTEPEPVKPEGLVVNGKEEEPSVE-- 658

  Fly   668 DDMENQLYERNRNVHNNSKCRRDLFATKRRDPHPSPE 704
            :.:...|.:...|...:....:|...:....| .|||
Mouse   659 EALSKGLGQMTTNADTDGDSYKDKTESVTSGP-LSPE 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hts	NP_001097377.2	Aldolase_II	116..323	CDD:238232	83/209 (40%)
Add2	NP_001258786.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		5/18 (28%)
		Aldolase_II	130..379	CDD:294146	105/275 (38%)
		Interaction with calmodulin. /evidence=ECO:0000255	425..444		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..725		51/189 (27%)
		IHABP4_N	553..655	CDD:292792	33/107 (31%)
		Interaction with calmodulin. /evidence=ECO:0000255	703..720
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844290
Domainoid	1	1.000	190	1.000	Domainoid score	I3259
eggNOG	1	0.900	-	-		E1_COG0235
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2057
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001205
OrthoInspector	1	1.000	-	-		otm44048
orthoMCL	1	0.900	-	-		OOG6_100477
Panther	1	1.100	-	-	O	PTHR10672
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X937
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.750