DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SdhA and FRD1

DIOPT Version :9

Sequence 1:	NP_477210.1	Gene:	SdhA / 37228	FlyBaseID:	FBgn0261439	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_010867.3	Gene:	FRD1 / 856664	SGDID:	S000000773	Length:	470	Species:	Saccharomyces cerevisiae

Alignment Length:	508	Identity:	139/508 - (27%)
Similarity:	204/508 - (40%)	Gaps:	139/508 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 IVVGAGGAGLRAAFGLVAE-GFRTAVITKLFPTRSHTIAAQGGINAALGNME-----EDDWKWHM 120
            :|:|.|.|||.||..||.: .....::.|......::|.|..|||.|....:     ||..:...
Yeast     7 VVIGTGLAGLAAANELVNKYNIPVTILEKASSIGGNSIKASSGINGACTETQRHFHIEDSPRLFE 71

  Fly   121 YDTVKGSDWLGDQDAIHYMTREAPKAVIELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHR 185
            .||:|.:...|.|:.:..:..::|.|:..|:|   .|....|   .....||.|:     .:.||
Yeast    72 DDTIKSAKGKGVQELMAKLANDSPLAIEWLKN---EFDLKLD---LLAQLGGHSV-----ARTHR 125

  Fly   186 CCAVADRTGHSLLHTLYGQ------------SLSYDCNYFVEYFALDLIFEDGECRGVLALNLED 238
            ...... .|..::..|...            .::.|..      .:|:..:||   .:.|:..||
Yeast   126 SSGKLP-PGFEIVSALSNNLKKLAETKPELVKINLDSK------VVDIHEKDG---SISAVVYED 180

  Fly   239 --GTLHRFRAKNTVIATGGYGRAFFS---------------CTSAHTCTGDGTAMVARQGLPSQD 286
              |..|...|.:.|..:||:|   ||               .|:....||||..::.:.|....|
Yeast   181 KNGEKHMVSANDVVFCSGGFG---FSKEMLKEYAPELVNLPTTNGQQTTGDGQRLLQKLGADLID 242

  Fly   287 LEFVQFHPTGIYGAG-------CLITEGCRGEGGYLING-NGERFMERYAPVAKDLASRDVVSRS 343
            ::.:|.||||.....       .|..|..||.||.|:|. .|.||:       .:|.:||||:.:
Yeast   243 MDQIQVHPTGFIDPNDRSSSWKFLAAESLRGLGGILLNPITGRRFV-------NELTTRDVVTAA 300

  Fly   344 MTIEIMEGRGAGPEKDH---------VYLQL------------------------HHLP--PKQL 373
            :       :...|::|:         :|..|                        ::||  ..||
Yeast   301 I-------QKVCPQEDNRALLVMGEKMYTDLKNNLDFYMFKKLVQKLTLSQVVSEYNLPITVAQL 358

  Fly   374 AERLPGIS----------ETAMIFA-GVDVTREPI----PVLPTVHYNMGGVPTNYRGQVITIDK 423
            .|.|...|          .|.::.. |.|||.|.:    .|.|.||:.|||...|.:.|||
Yeast   359 CEELQTYSSFTTKADPLGRTVILNEFGSDVTPETVVFIGEVTPVVHFTMGGARINVKAQVI---- 419

  Fly   424 DGK--DVIVPGLYAAGEAASSSVHGANRLGANSLLDLVVFGRACAKTIAELNK 474
             ||  :.::.||||||| .|..||||||||.:|||:.|||||..|::||...|
Yeast   420 -GKNDERLLKGLYAAGE-VSGGVHGANRLGGSSLLECVVFGRTAAESIANDRK 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdhA	NP_477210.1	PTZ00139	49..661	CDD:240286	139/508 (27%)
		NADB_Rossmann	80..469	CDD:304358	126/483 (26%)
		Succ_DH_flav_C	511..661	CDD:280980
FRD1	NP_010867.3	flavo_cyto_c	5..463	CDD:273816	135/499 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.957091	Normalized mean entropy	S148
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760