DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SdhA and SDH1

DIOPT Version :9

Sequence 1:	NP_477210.1	Gene:	SdhA / 37228	FlyBaseID:	FBgn0261439	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_012774.1	Gene:	SDH1 / 853709	SGDID:	S000001631	Length:	640	Species:	Saccharomyces cerevisiae

Alignment Length:	630	Identity:	415/630 - (65%)
Similarity:	499/630 - (79%)	Gaps:	21/630 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 THGRQQASAANPDKISKQYPVVDHAYDAIVVGAGGAGLRAAFGLVAEGFRTAVITKLFPTRSHTI 98
            |.|....||:.  ....:|.::||.||.:|:|||||||||||||...|::||.|:|||||||||:
Yeast    30 TQGSVNGSASR--SADGKYHIIDHEYDCVVIGAGGAGLRAAFGLAEAGYKTACISKLFPTRSHTV 92

  Fly    99 AAQGGINAALGNMEEDDWKWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELENYGMPFSRTQDG 163
            |||||||||||||.:|:|||||||||||||||||||:||||||||||::||||:||:|||||::|
Yeast    93 AAQGGINAALGNMHKDNWKWHMYDTVKGSDWLGDQDSIHYMTREAPKSIIELEHYGVPFSRTENG 157

  Fly   164 KIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSLSYDCNYFVEYFALDLIFEDGEC 228
            ||||||||||:.::|||.||:|.|||||||||:||||||||:|.:|.::|:|||||||:..:||.
Yeast   158 KIYQRAFGGQTKEYGKGAQAYRTCAVADRTGHALLHTLYGQALRHDTHFFIEYFALDLLTHNGEV 222

  Fly   229 RGVLALNLEDGTLHRFRAKNTVIATGGYGRAFFSCTSAHTCTGDGTAMVARQGLPSQDLEFVQFH 293
            .||:|.|.||||:|||||..|:|||||||||:|||||||||||||.|||:|.|.|.|||||||||
Yeast   223 VGVIAYNQEDGTIHRFRAHKTIIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLQDLEFVQFH 287

  Fly   294 PTGIYGAGCLITEGCRGEGGYLINGNGERFMERYAPVAKDLASRDVVSRSMTIEIMEGRGAGPEK 358
            |:||||:|||||||.|||||:|:|..||||||||||.|||||.||||||::|:||.||||.|.:|
Yeast   288 PSGIYGSGCLITEGARGEGGFLVNSEGERFMERYAPTAKDLACRDVVSRAITMEIREGRGVGKKK 352

  Fly   359 DHVYLQLHHLPPKQLAERLPGISETAMIFAGVDVTREPIPVLPTVHYNMGGVPTNYRGQVITIDK 423
            ||:||||.||||:.|.||||||||||.||||||||:||||::|||||||||:||.:.|:.:|||:
Yeast   353 DHMYLQLSHLPPEVLKERLPGISETAAIFAGVDVTKEPIPIIPTVHYNMGGIPTKWNGEALTIDE 417

  Fly   424 D-GKDVIVPGLYAAGEAASSSVHGANRLGANSLLDLVVFGRACAKTIAELNKPGAPAPTLKENAG 487
            : |:|.::|||.|.||||..||||||||||||||||||||||.|.|:|:..:||.|...|..:.|
Yeast   418 ETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVAHTVADTLQPGLPHKPLPSDLG 482

  Fly   488 EASVANLDKLRHANGQITTADLRLKMQKTMQHHAAVFRDGPILQDGVNKMKEIYKQFKDIKVVDR 552
            :.|:|||||||:|||..:||::|:.|::|||...:|||....|.:||..:..:.|.|.|:|..||
Yeast   483 KESIANLDKLRNANGSRSTAEIRMNMKQTMQKDVSVFRTQSSLDEGVRNITAVEKTFDDVKTTDR 547

  Fly   553 SLIWNSDLVETLELQNLLANAQMTIVSAEARKESRGAHAREDFKVREDEYDFSKPLDGQQKKPMD 617
            |:||||||||||||||||..|..|.|||..||||||||||||:..|:||
Yeast   548 SMIWNSDLVETLELQNLLTCASQTAVSAANRKESRGAHAREDYPNRDDE---------------- 596

  Fly   618 QHWRKHTLSWVCNDNGDITLDYRNVIDTTLD-NEVSTVPPAIRSY 661
             ||.||||||..:....:||.||.|||.||| .|..:|||.:|:|
Yeast   597 -HWMKHTLSWQKDVAAPVTLKYRRVIDHTLDEKECPSVPPTVRAY 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdhA	NP_477210.1	PTZ00139	49..661	CDD:240286	410/613 (67%)
		NADB_Rossmann	80..469	CDD:304358	294/389 (76%)
		Succ_DH_flav_C	511..661	CDD:280980	76/150 (51%)
SDH1	NP_012774.1	SdhA	46..640	CDD:393461	410/610 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	637	1.000	Domainoid score	I16
eggNOG	1	0.900	-	-		E1_COG1053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3073
Inparanoid	1	1.050	840	1.000	Inparanoid score	I51
Isobase	1	0.950	-	0.957091	Normalized mean entropy	S148
OMA	1	1.010	-	-		QHG60640
OrthoFinder	1	1.000	-	-		FOG0002411
OrthoInspector	1	1.000	-	-		otm46908
orthoMCL	1	0.900	-	-		OOG6_100447
Panther	1	1.100	-	-	LDO	PTHR11632
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R308
SonicParanoid	1	1.000	-	-		X1604
TreeFam	1	0.960	-	-
	15	14.810