DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SdhA and OSM1

DIOPT Version :9

Sequence 1:	NP_477210.1	Gene:	SdhA / 37228	FlyBaseID:	FBgn0261439	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_012585.1	Gene:	OSM1 / 853510	SGDID:	S000003812	Length:	501	Species:	Saccharomyces cerevisiae

Alignment Length:	530	Identity:	126/530 - (23%)
Similarity:	206/530 - (38%)	Gaps:	161/530 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 DKISKQYPVVDHAYDAIVVGAGGAGLRAAFGLVAEGFRTAVI--TKLFPTRSHTIAAQGGINAAL 108
            |:.|.:.|||       |:|:|.|||..:..|::: :|..|:  .|......::|.|..|||.|.
Yeast    29 DQTSMKQPVV-------VIGSGLAGLTTSNRLISK-YRIPVVLLDKAASIGGNSIKASSGINGAH 85

  Fly   109 GNMEE-----DDWKWHMYDTVKGSDWLGDQDAIHYMTREAPKAV--------------IELENYG 154
            .:.::     |..:..:.||:..:...|....:..:|:|:..|:              .:|..:.
Yeast    86 TDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHS 150

  Fly   155 MPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSL----SYDCN---Y 212
            :|.:....||:                          ..|..::..| .:.|    |.|.|   .
Yeast   151 VPRTHRSSGKL--------------------------PPGFEIVQAL-SKKLKDISSKDSNLVQI 188

  Fly   213 FVEYFALDLIFED-GECRGVLALNLEDGTLHRFRAKNTVIATGGYGRA------------FFSCT 264
            .:....:|:..:: |...||:.:: |:|.....::.:.|..:||:|.:            ....|
Yeast   189 MLNSEVVDIELDNQGHVTGVVYMD-ENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTT 252

  Fly   265 SAHTCTGDGTAMVARQGLPSQDLEFVQFHPTGIYGAG-------CLITEGCRGEGGYLIN-GNGE 321
            :....||||..::::.|....|::.||.||||.....       .|..|..||.||.|:: ..|.
Yeast   253 NGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGR 317

  Fly   322 RFMERYAPVAKDLASRDVVSRSMTIEIM------EGRGAGPEKDHVY----LQLHHLPPKQLAER 376
            ||       ..:|::||.|    |:||.      :.|......|.||    ..::....|.|.::
Yeast   318 RF-------TNELSTRDTV----TMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKK 371

  Fly   377 L--------------------------------------------PGISETAMIFAGVDVTREPI 397
            :                                            ..||..:.::.|
Yeast   372 VSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVG-------- 428

  Fly   398 PVLPTVHYNMGGVPTNYRGQVITIDKDGKDVIVPGLYAAGEAASSSVHGANRLGANSLLDLVVFG 462
            .|.|.||:.||||..|.:.||  |.|:.:.|:..|::|||| .|..||||||||.:|||:.||||
Yeast   429 EVTPVVHFTMGGVKINEKSQV--IKKNSESVLSNGIFAAGE-VSGGVHGANRLGGSSLLECVVFG 490

  Fly   463 RACAKTIAEL 472
            :..|..||:|
Yeast   491 KTAADNIAKL 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdhA	NP_477210.1	PTZ00139	49..661	CDD:240286	125/527 (24%)
		NADB_Rossmann	80..469	CDD:304358	111/491 (23%)
		Succ_DH_flav_C	511..661	CDD:280980
OSM1	NP_012585.1	flavo_cyto_c	36..495	CDD:273816	120/516 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.957091	Normalized mean entropy	S148
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760