DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SdhA and SDH9

DIOPT Version :9

Sequence 1:	NP_477210.1	Gene:	SdhA / 37228	FlyBaseID:	FBgn0261439	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_012490.1	Gene:	SDH9 / 853405	SGDID:	S000003581	Length:	634	Species:	Saccharomyces cerevisiae

Alignment Length:	645	Identity:	421/645 - (65%)
Similarity:	499/645 - (77%)	Gaps:	26/645 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GVQRSYHITHG-------RQQASAANPDKISKQYPVVDHAYDAIVVGAGGAGLRAAFGLVAEGFR 83
            |:.:||.:...       ||.....:..|...:|.::||.||.:|||||||||||||||...|::
Yeast     7 GITKSYILQRTFTSSSVVRQIGEVKSESKPPAKYHIIDHEYDCVVVGAGGAGLRAAFGLAEAGYK 71

  Fly    84 TAVITKLFPTRSHTIAAQGGINAALGNMEEDDWKWHMYDTVKGSDWLGDQDAIHYMTREAPKAVI 148
            ||.::|||||||||:|||||||||||||..||||.|||||||||||||||||||||||||||:||
Yeast    72 TACLSKLFPTRSHTVAAQGGINAALGNMHPDDWKSHMYDTVKGSDWLGDQDAIHYMTREAPKSVI 136

  Fly   149 ELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSLSYDCNYF 213
            |||:||||||||:||:||||||||||..|||||||:|.|||||||||::|||||||:|..:.::|
Yeast   137 ELEHYGMPFSRTEDGRIYQRAFGGQSKDFGKGGQAYRTCAVADRTGHAMLHTLYGQALKNNTHFF 201

  Fly   214 VEYFALDLIFEDGECRGVLALNLEDGTLHRFRAKNTVIATGGYGRAFFSCTSAHTCTGDGTAMVA 278
            :||||:||:..:||..||:|.|.||||:|||||..|||||||||||:|||||||||||||.|||:
Yeast   202 IEYFAMDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTVIATGGYGRAYFSCTSAHTCTGDGNAMVS 266

  Fly   279 RQGLPSQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLINGNGERFMERYAPVAKDLASRDVVSRS 343
            |.|.|.:|||||||||:||||:|||||||.|||||:|:|..||||||||||.||||||||||||:
Yeast   267 RAGFPLEDLEFVQFHPSGIYGSGCLITEGARGEGGFLLNSEGERFMERYAPTAKDLASRDVVSRA 331

  Fly   344 MTIEIMEGRGAGPEKDHVYLQLHHLPPKQLAERLPGISETAMIFAGVDVTREPIPVLPTVHYNMG 408
            :|:||..|||.|..|||:.|||.||||:.|.||||||||||.:|||||||:||||||||||||||
Yeast   332 ITMEIRAGRGVGKNKDHILLQLSHLPPEVLKERLPGISETAAVFAGVDVTQEPIPVLPTVHYNMG 396

  Fly   409 GVPTNYRGQVITIDKD-GKDVIVPGLYAAGEAASSSVHGANRLGANSLLDLVVFGRACAKTIAEL 472
            |:||.:.|:.:|||:: |:|.::|||.|.||||..||||||||||||||||||||||.|.|||:.
Yeast   397 GIPTKWTGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVANTIADT 461

  Fly   473 NKPGAPAPTLKENAGEASVANLDKLRHANGQITTADLRLKMQKTMQHHAAVFRDGPILQDGVNKM 537
            .:||.|...|..|.|..|:|||||:|:|.|.:.|:.:||.||:|||...:|||....|.:||..:
Yeast   462 LQPGLPHKPLASNIGHESIANLDKVRNARGSLKTSQIRLNMQRTMQKDVSVFRTQDTLDEGVRNI 526

  Fly   538 KEIYKQFKDIKVVDRSLIWNSDLVETLELQNLLANAQMTIVSAEARKESRGAHAREDFKVREDEY 602
            .|:.|.|:|:.|.|:|:||||||||||||||||..|..|.|||..||||||||||||:..|:
Yeast   527 TEVDKTFEDVHVSDKSMIWNSDLVETLELQNLLTCATQTAVSASKRKESRGAHAREDYAKRD--- 588

  Fly   603 DFSKPLDGQQKKPMDQHWRKHTLSWVCNDNGDITLDYRNVIDTTLD-NEVSTVPPAIRSY 661
                          |.:||||||||....:..:.:.|||||..||| ||.:.||||:|||
Yeast   589 --------------DVNWRKHTLSWQKGTSTPVKIKYRNVIAHTLDENECAPVPPAVRSY 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdhA	NP_477210.1	PTZ00139	49..661	CDD:240286	413/613 (67%)
		NADB_Rossmann	80..469	CDD:304358	296/389 (76%)
		Succ_DH_flav_C	511..661	CDD:280980	77/150 (51%)
SDH9	NP_012490.1	PTZ00139	5..634	CDD:240286	419/643 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344480
Domainoid	1	1.000	637	1.000	Domainoid score	I16
eggNOG	1	0.900	-	-		E1_COG1053
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	840	1.000	Inparanoid score	I51
Isobase	1	0.950	-	0.957091	Normalized mean entropy	S148
OMA	1	1.010	-	-		QHG60640
OrthoFinder	1	1.000	-	-		FOG0002411
OrthoInspector	1	1.000	-	-		otm46908
orthoMCL	1	0.900	-	-		OOG6_100447
Panther	1	1.100	-	-	O	PTHR11632
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R308
SonicParanoid	1	1.000	-	-		X1604
TreeFam	1	0.960	-	-
	15	14.740