Protein Alignment SdhA and SDH9

DIOPT Version :10

• Sequence 1: NP_477210.1
• Gene: SdhA / 37228
• FlyBaseID: FBgn0261439
• Length: 661
• Species: Drosophila melanogaster
• Sequence 2: NP_012490.1
• Gene: SDH9 / 853405
• SGDID: S000003581
• Length: 634
• Species: Saccharomyces cerevisiae
• Alignment Length: 645
• Identity: 421/645 - (65%)
• Similarity: 499/645 - (77%)
• Gaps: 26/645 - (4%)

  Fly    26 GVQRSYHITHG-------RQQASAANPDKISKQYPVVDHAYDAIVVGAGGAGLRAAFGLVAEGFR 83
            |:.:||.:...       ||.....:..|...:|.::||.||.:|||||||||||||||...|::
Yeast     7 GITKSYILQRTFTSSSVVRQIGEVKSESKPPAKYHIIDHEYDCVVVGAGGAGLRAAFGLAEAGYK 71

  Fly    84 TAVITKLFPTRSHTIAAQGGINAALGNMEEDDWKWHMYDTVKGSDWLGDQDAIHYMTREAPKAVI 148
            ||.::|||||||||:|||||||||||||..||||.|||||||||||||||||||||||||||:||
Yeast    72 TACLSKLFPTRSHTVAAQGGINAALGNMHPDDWKSHMYDTVKGSDWLGDQDAIHYMTREAPKSVI 136

  Fly   149 ELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSLSYDCNYF 213
            |||:||||||||:||:||||||||||..|||||||:|.|||||||||::|||||||:|..:.::|
Yeast   137 ELEHYGMPFSRTEDGRIYQRAFGGQSKDFGKGGQAYRTCAVADRTGHAMLHTLYGQALKNNTHFF 201

  Fly   214 VEYFALDLIFEDGECRGVLALNLEDGTLHRFRAKNTVIATGGYGRAFFSCTSAHTCTGDGTAMVA 278
            :||||:||:..:||..||:|.|.||||:|||||..|||||||||||:|||||||||||||.|||:
Yeast   202 IEYFAMDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTVIATGGYGRAYFSCTSAHTCTGDGNAMVS 266

  Fly   279 RQGLPSQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLINGNGERFMERYAPVAKDLASRDVVSRS 343
            |.|.|.:|||||||||:||||:|||||||.|||||:|:|..||||||||||.||||||||||||:
Yeast   267 RAGFPLEDLEFVQFHPSGIYGSGCLITEGARGEGGFLLNSEGERFMERYAPTAKDLASRDVVSRA 331

  Fly   344 MTIEIMEGRGAGPEKDHVYLQLHHLPPKQLAERLPGISETAMIFAGVDVTREPIPVLPTVHYNMG 408
            :|:||..|||.|..|||:.|||.||||:.|.||||||||||.:|||||||:||||||||||||||
Yeast   332 ITMEIRAGRGVGKNKDHILLQLSHLPPEVLKERLPGISETAAVFAGVDVTQEPIPVLPTVHYNMG 396

  Fly   409 GVPTNYRGQVITIDKD-GKDVIVPGLYAAGEAASSSVHGANRLGANSLLDLVVFGRACAKTIAEL 472
            |:||.:.|:.:|||:: |:|.::|||.|.||||..||||||||||||||||||||||.|.|||:.
Yeast   397 GIPTKWTGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVANTIADT 461

  Fly   473 NKPGAPAPTLKENAGEASVANLDKLRHANGQITTADLRLKMQKTMQHHAAVFRDGPILQDGVNKM 537
            .:||.|...|..|.|..|:|||||:|:|.|.:.|:.:||.||:|||...:|||....|.:||..:
Yeast   462 LQPGLPHKPLASNIGHESIANLDKVRNARGSLKTSQIRLNMQRTMQKDVSVFRTQDTLDEGVRNI 526

  Fly   538 KEIYKQFKDIKVVDRSLIWNSDLVETLELQNLLANAQMTIVSAEARKESRGAHAREDFKVREDEY 602
            .|:.|.|:|:.|.|:|:||||||||||||||||..|..|.|||..||||||||||||:..|:
Yeast   527 TEVDKTFEDVHVSDKSMIWNSDLVETLELQNLLTCATQTAVSASKRKESRGAHAREDYAKRD--- 588

  Fly   603 DFSKPLDGQQKKPMDQHWRKHTLSWVCNDNGDITLDYRNVIDTTLD-NEVSTVPPAIRSY 661
                          |.:||||||||....:..:.:.|||||..||| ||.:.||||:|||
Yeast   589 --------------DVNWRKHTLSWQKGTSTPVKIKYRNVIAHTLDENECAPVPPAVRSY 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SdhA	NP_477210.1	PTZ00139	49..661	CDD:240286	413/613 (67%)
SDH9	NP_012490.1	FAD_binding_2	5..634	CDD:481218	419/643 (65%)