DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SdhA and SDH1-2

DIOPT Version :9

Sequence 1:	NP_477210.1	Gene:	SdhA / 37228	FlyBaseID:	FBgn0261439	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_179435.1	Gene:	SDH1-2 / 816359	AraportID:	AT2G18450	Length:	632	Species:	Arabidopsis thaliana

Alignment Length:	650	Identity:	433/650 - (66%)
Similarity:	511/650 - (78%)	Gaps:	31/650 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ASMQRAAAVGVQRSYHITHGRQQASAANP---DKISKQYPVVDHAYDAIVVGAGGAGLRAAFGLV 78
            :|.:|:.:.|.    .||....:..:|.|   ||.|  |.:|||.|||:||||||||||||.||.
plant     9 SSSRRSESNGA----FITSQLSRFFSAPPSAGDKSS--YTIVDHTYDAVVVGAGGAGLRAAIGLS 67

  Fly    79 AEGFRTAVITKLFPTRSHTIAAQGGINAALGNMEEDDWKWHMYDTVKGSDWLGDQDAIHYMTREA 143
            ..||.||.|||||||||||:|||||||||||||..|||:|||||||||||||||||||.||.|||
plant    68 EHGFNTACITKLFPTRSHTVAAQGGINAALGNMSVDDWRWHMYDTVKGSDWLGDQDAIQYMCREA 132

  Fly   144 PKAVIELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSLSY 208
            |||||||||||:|||||:||||||||||||||:||.||||:||...||||||:||||||||::.:
plant   133 PKAVIELENYGLPFSRTEDGKIYQRAFGGQSLEFGIGGQAYRCACAADRTGHALLHTLYGQAMKH 197

  Fly   209 DCNYFVEYFALDLIF-EDGECRGVLALNLEDGTLHRFRAKNTVIATGGYGRAFFSCTSAHTCTGD 272
            :..:||||||||||. .||.|:||:|||:||||||||.|.:|::||||||||:||.|||||||||
plant   198 NTQFFVEYFALDLIMNSDGTCQGVIALNMEDGTLHRFHAGSTILATGGYGRAYFSATSAHTCTGD 262

  Fly   273 GTAMVARQGLPSQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLINGNGERFMERYAPVAKDLASR 337
            |.|||||.|||.|||||||||||||||||||||||.|||||.|.|..||:||:||||.|:|||||
plant   263 GNAMVARAGLPLQDLEFVQFHPTGIYGAGCLITEGARGEGGILRNSEGEKFMDRYAPTARDLASR 327

  Fly   338 DVVSRSMTIEIMEGRGAGPEKDHVYLQLHHLPPKQLAERLPGISETAMIFAGVDVTREPIPVLPT 402
            ||||||||:||.:||||||.||::||.|:||||:.|.||||||||||.|||||||||||||||||
plant   328 DVVSRSMTMEIRQGRGAGPMKDYLYLYLNHLPPEVLKERLPGISETAAIFAGVDVTREPIPVLPT 392

  Fly   403 VHYNMGGVPTNYRGQVITIDKDGKDVIVPGLYAAGEAASSSVHGANRLGANSLLDLVVFGRACAK 467
            |||||||:||||.|:|||:..|..|.:||||.||||||.:|||||||||||||||:||||||||.
plant   393 VHYNMGGIPTNYHGEVITLRGDDPDAVVPGLMAAGEAACASVHGANRLGANSLLDIVVFGRACAN 457

  Fly   468 TIAELNKPGAPAPTLKENAGEASVANLDKLRHANGQITTADLRLKMQKTMQHHAAVFRDGPILQD 532
            .:||:.|||.....|:::|||.|:..||::|::||.:.|:.:||.||:.||::|||||....|::
plant   458 RVAEIQKPGEKLKPLEKDAGEKSIEWLDRIRNSNGSLPTSKIRLNMQRVMQNNAAVFRTQETLEE 522

  Fly   533 GVNKMKEIYKQFKDIKVVDRSLIWNSDLVETLELQNLLANAQMTIVSAEARKESRGAHAREDFKV 597
            |.:.:.:.:..|.|:||.|||:||||||:||:||:|||.||.:|:.|||||||||||||||||..
plant   523 GCDLIDKTWDSFGDVKVTDRSMIWNSDLIETMELENLLVNACITMHSAEARKESRGAHAREDFTK 587

  Fly   598 REDEYDFSKPLDGQQKKPMDQHWRKHTLS-WVCNDNGDITLDYRNVIDTTLDNEVSTVPPAIRSY 661
            |:                 |.:|.||||. |   :.|::.|:||.|...|||:||.|.||..|.|
plant   588 RD-----------------DANWMKHTLGYW---EEGNVKLEYRPVHMKTLDDEVDTFPPKPRVY 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdhA	NP_477210.1	PTZ00139	49..661	CDD:240286	423/613 (69%)
		NADB_Rossmann	80..469	CDD:304358	310/389 (80%)
		Succ_DH_flav_C	511..661	CDD:280980	74/150 (49%)
SDH1-2	NP_179435.1	PLN00128	1..632	CDD:177739	432/648 (67%)
		NADB_Rossmann	71..482	CDD:304358	319/410 (78%)
		Succ_DH_flav_C	501..632	CDD:280980	74/150 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	668	1.000	Domainoid score	I21
eggNOG	1	0.900	-	-		E1_COG1053
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	864	1.000	Inparanoid score	I62
OMA	1	1.010	-	-		QHG60640
OrthoDB	1	1.010	-	-		D606981at2759
OrthoFinder	1	1.000	-	-		FOG0002411
OrthoInspector	1	1.000	-	-		otm3279
orthoMCL	1	0.900	-	-		OOG6_100447
Panther	1	1.100	-	-	O	PTHR11632
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1604
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840