Protein Alignment SdhA and SDHA

DIOPT Version :9

• Sequence 1: NP_477210.1
• Gene: SdhA / 37228
• FlyBaseID: FBgn0261439
• Length: 661
• Species: Drosophila melanogaster
• Sequence 2: XP_016865174.1
• Gene: SDHA / 6389
• HGNCID: 10680
• Length: 785
• Species: Homo sapiens
• Alignment Length: 642
• Identity: 474/642 - (73%)
• Similarity: 542/642 - (84%)
• Gaps: 6/642 - (0%)

  Fly     1 MSGIMRVPSILAKNAVASMQRAAAVGVQ---RSYHIT-HGRQQASAANPDKISKQYPVVDHAYDA 61
            |||:..:..:|:...:| :.:|....:|   |.:|.| .|.::|||...|.||.|||||||.:||
Human     1 MSGVRGLSRLLSARRLA-LAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDHEFDA 64

  Fly    62 IVVGAGGAGLRAAFGLVAEGFRTAVITKLFPTRSHTIAAQGGINAALGNMEEDDWKWHMYDTVKG 126
            :|||||||||||||||...||.||.:||||||||||:||||||||||||||||:|:||.||||||
Human    65 VVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKG 129

  Fly   127 SDWLGDQDAIHYMTREAPKAVIELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVAD 191
            ||||||||||||||.:||.||:||||||||||||:||||||||||||||||||||||||||.|||
Human   130 SDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVAD 194

  Fly   192 RTGHSLLHTLYGQSLSYDCNYFVEYFALDLIFEDGECRGVLALNLEDGTLHRFRAKNTVIATGGY 256
            ||||||||||||:||.||.:||||||||||:.|:||||||:||.:|||::||.||||||:|||||
Human   195 RTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVVATGGY 259

  Fly   257 GRAFFSCTSAHTCTGDGTAMVARQGLPSQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLINGNGE 321
            ||.:||||||||.|||||||:.|.|||.|||||||||||||||||||||||||||||.|||..||
Human   260 GRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGE 324

  Fly   322 RFMERYAPVAKDLASRDVVSRSMTIEIMEGRGAGPEKDHVYLQLHHLPPKQLAERLPGISETAMI 386
            ||||||||||||||||||||||||:||.||||.||||||||||||||||:|||.|||||||||||
Human   325 RFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMI 389

  Fly   387 FAGVDVTREPIPVLPTVHYNMGGVPTNYRGQVITIDKDGKDVIVPGLYAAGEAASSSVHGANRLG 451
            |||||||:|||||||||||||||:||||:|||:. ..:|:|.|||||||.||||.:|||||||||
Human   390 FAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLR-HVNGQDQIVPGLYACGEAACASVHGANRLG 453

  Fly   452 ANSLLDLVVFGRACAKTIAELNKPGAPAPTLKENAGEASVANLDKLRHANGQITTADLRLKMQKT 516
            |||||||||||||||.:|.|..:||...|.:|.||||.||.||||||.|:|.|.|::|||.|||:
Human   454 ANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKS 518

  Fly   517 MQHHAAVFRDGPILQDGVNKMKEIYKQFKDIKVVDRSLIWNSDLVETLELQNLLANAQMTIVSAE 581
            ||:||||||.|.:||:|..|:.::|...|.:|..||.::||:|||||||||||:..|..||..||
Human   519 MQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAE 583

  Fly   582 ARKESRGAHAREDFKVREDEYDFSKPLDGQQKKPMDQHWRKHTLSWVCNDNGDITLD 638
            |||||||||||||:|||.||||:|||:.||||||.::||||||||:|....|.::::
Human   584 ARKESRGAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKVSVE 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SdhA	NP_477210.1	PTZ00139	49..661	CDD:240286	458/590 (78%)
		NADB_Rossmann	80..469	CDD:304358	330/388 (85%)
		Succ_DH_flav_C	511..661	CDD:280980	79/128 (62%)
SDHA	XP_016865174.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150024
Domainoid	1	1.000	706	1.000	Domainoid score	I122
eggNOG	1	0.900	-	-		E1_COG1053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3073
Inparanoid	1	1.050	1002	1.000	Inparanoid score	I297
Isobase	1	0.950	-	0.957091	Normalized mean entropy	S148
OMA	1	1.010	-	-		QHG60640
OrthoDB	1	1.010	-	-		D171709at33208
OrthoFinder	1	1.000	-	-		FOG0002411
OrthoInspector	1	1.000	-	-		oto90965
orthoMCL	1	0.900	-	-		OOG6_100447
Panther	1	1.100	-	-	LDO	PTHR11632
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R308
SonicParanoid	1	1.000	-	-		X1604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750