Protein Alignment SdhA and sdha

DIOPT Version :9

• Sequence 1: NP_477210.1
• Gene: SdhA / 37228
• FlyBaseID: FBgn0261439
• Length: 661
• Species: Drosophila melanogaster
• Sequence 2: NP_957204.1
• Gene: sdha / 393884
• ZFINID: ZDB-GENE-040426-874
• Length: 661
• Species: Danio rerio
• Alignment Length: 662
• Identity: 493/662 - (74%)
• Similarity: 555/662 - (83%)
• Gaps: 2/662 - (0%)

  Fly     1 MSGIMRVPSILAKNAVASMQRAAAVGVQRSYHITHGRQQASAANPDKISKQYPVVDHAYDAIVVG 65
            |:.:.....:|....::|....|.....|..|.:...::..|...|.:|.|||||||.:||:|||
Zfish     1 MAAVCAASRVLGTKILSSKSLPAVCQANRQLHFSIYGKRGDAKISDGVSNQYPVVDHEFDAVVVG 65

  Fly    66 AGGAGLRAAFGLVAEGFRTAVITKLFPTRSHTIAAQGGINAALGNMEEDDWKWHMYDTVKGSDWL 130
            ||||||||||||...||.||.:||||||||||:||||||||||||||:|||:||.||||||||||
Zfish    66 AGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEQDDWRWHFYDTVKGSDWL 130

  Fly   131 GDQDAIHYMTREAPKAVIELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGH 195
            ||||||||||.:||.||:||||:|||||||.||||||||||||||||||||||||||.|||||||
Zfish   131 GDQDAIHYMTEQAPAAVVELENFGMPFSRTDDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGH 195

  Fly   196 SLLHTLYGQSLSYDCNYFVEYFALDLIFEDGECRGVLALNLEDGTLHRFRAKNTVIATGGYGRAF 260
            ||||||||:||.||.:||||||||||:.|||||:||:||.:|||::|||||||||||||||||.|
Zfish   196 SLLHTLYGRSLRYDTSYFVEYFALDLLMEDGECKGVIALCMEDGSIHRFRAKNTVIATGGYGRTF 260

  Fly   261 FSCTSAHTCTGDGTAMVARQGLPSQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLINGNGERFME 325
            ||||||||.||||.|||.|.|||.|||||||||||||||||||||||||||||.|||..||||||
Zfish   261 FSCTSAHTSTGDGNAMVTRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSEGERFME 325

  Fly   326 RYAPVAKDLASRDVVSRSMTIEIMEGRGAGPEKDHVYLQLHHLPPKQLAERLPGISETAMIFAGV 390
            ||||.||||||||||||||||||.||||.||:||||:||||||||:|||.|||||||||||||||
Zfish   326 RYAPNAKDLASRDVVSRSMTIEIREGRGVGPDKDHVHLQLHHLPPQQLAARLPGISETAMIFAGV 390

  Fly   391 DVTREPIPVLPTVHYNMGGVPTNYRGQVITIDKDGKDVIVPGLYAAGEAASSSVHGANRLGANSL 455
            |||:|||||||||||||||:||||:|||||. |||:|.:||||||.|||..:|||||||||||||
Zfish   391 DVTKEPIPVLPTVHYNMGGIPTNYKGQVITY-KDGQDHVVPGLYACGEAGCASVHGANRLGANSL 454

  Fly   456 LDLVVFGRACAKTIAELNKPGAPAPTLKENAGEASVANLDKLRHANGQITTADLRLKMQKTMQHH 520
            |||||||||||.||||::.||.....||.||||||||||||:|:|||...|:::||.||||||.|
Zfish   455 LDLVVFGRACALTIAEIDTPGEKLSPLKPNAGEASVANLDKMRYANGSTRTSEIRLNMQKTMQSH 519

  Fly   521 AAVFRDGPILQDGVNKMKEIYKQFKDIKVVDRSLIWNSDLVETLELQNLLANAQMTIVSAEARKE 585
            |||||.|.:|::|..||:.:||...:||..||.::||:|||||||||||:.||..||||||||||
Zfish   520 AAVFRTGDVLKEGCVKMESVYKSMDNIKTFDRGIVWNTDLVETLELQNLMLNAVQTIVSAEARKE 584

  Fly   586 SRGAHAREDFKVREDEYDFSKPLDGQQKKPMDQHWRKHTLSWVCNDNGDITLDYRNVIDTTLDNE 650
            |||||||||||.|.||||:||||.||.|||.:|||||||||:|..:.|.:||:||.|||::||.|
Zfish   585 SRGAHAREDFKDRVDEYDYSKPLQGQVKKPFEQHWRKHTLSYVDPETGKVTLEYRPVIDSSLDAE 649

  Fly   651 -VSTVPPAIRSY 661
             .:.:|||||||
Zfish   650 DCAAIPPAIRSY 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SdhA	NP_477210.1	PTZ00139	49..661	CDD:240286	483/612 (79%)
		NADB_Rossmann	80..469	CDD:304358	332/388 (86%)
		Succ_DH_flav_C	511..661	CDD:280980	100/150 (67%)
sdha	NP_957204.1	PTZ00139	45..661	CDD:240286	484/616 (79%)
		NADB_Rossmann	82..468	CDD:304358	331/386 (86%)
		Succ_DH_flav_C	510..661	CDD:280980	100/150 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584250
Domainoid	1	1.000	710	1.000	Domainoid score	I117
eggNOG	1	0.900	-	-		E1_COG1053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3073
Inparanoid	1	1.050	1012	1.000	Inparanoid score	I278
OMA	1	1.010	-	-		QHG60640
OrthoDB	1	1.010	-	-		D171709at33208
OrthoFinder	1	1.000	-	-		FOG0002411
OrthoInspector	1	1.000	-	-		oto39804
orthoMCL	1	0.900	-	-		OOG6_100447
Panther	1	1.100	-	-	LDO	PTHR11632
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R308
SonicParanoid	1	1.000	-	-		X1604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800