Protein Alignment SdhA and sdha-2

DIOPT Version :9

• Sequence 1: NP_477210.1
• Gene: SdhA / 37228
• FlyBaseID: FBgn0261439
• Length: 661
• Species: Drosophila melanogaster
• Sequence 2: NP_492798.1
• Gene: sdha-2 / 172968
• WormBaseID: WBGene00016392
• Length: 640
• Species: Caenorhabditis elegans
• Alignment Length: 650
• Identity: 451/650 - (69%)
• Similarity: 523/650 - (80%)
• Gaps: 14/650 - (2%)

  Fly    14 NAVASMQRAAAVGVQRSYHITHGRQQASAANPDKISKQYPVVDHAYDAIVVGAGGAGLRAAFGLV 78
            |.|.|:.||      ::...|:.::|.||      :..:.||||.:||:||||||||||||.||.
 Worm     3 NVVKSINRA------KTPVRTYMKKQVSA------TTNFDVVDHTFDAVVVGAGGAGLRAAMGLS 55

  Fly    79 AEGFRTAVITKLFPTRSHTIAAQGGINAALGNMEEDDWKWHMYDTVKGSDWLGDQDAIHYMTREA 143
            ..|.:||||||||||||||:|||||:|||||||..|:|:||.|||||||||||||||||||||||
 Worm    56 EGGMKTAVITKLFPTRSHTVAAQGGVNAALGNMNPDNWRWHFYDTVKGSDWLGDQDAIHYMTREA 120

  Fly   144 PKAVIELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSLSY 208
            .:|:|||||||||||||.|||||||||||||..||:||||||.|.|||||||||||||||.||.|
 Worm   121 ERAIIELENYGMPFSRTTDGKIYQRAFGGQSNDFGRGGQAHRTCCVADRTGHSLLHTLYGASLQY 185

  Fly   209 DCNYFVEYFALDLIFEDGECRGVLALNLEDGTLHRFRAKNTVIATGGYGRAFFSCTSAHTCTGDG 273
            ||||||||||||||.:.|:|.||:||::|.|.:|||||||||:||||||||:|||||||||||||
 Worm   186 DCNYFVEYFALDLIMDKGKCIGVVALDIETGQIHRFRAKNTVLATGGYGRAYFSCTSAHTCTGDG 250

  Fly   274 TAMVARQGLPSQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLINGNGERFMERYAPVAKDLASRD 338
            ||:.||.|:.:.|:||||||||||||.|||||||.|||||||:|..||||||||||.||||||||
 Worm   251 TALTARAGIRNSDMEFVQFHPTGIYGVGCLITEGSRGEGGYLVNSQGERFMERYAPNAKDLASRD 315

  Fly   339 VVSRSMTIEIMEGRGAGPEKDHVYLQLHHLPPKQLAERLPGISETAMIFAGVDVTREPIPVLPTV 403
            ||||:||:||.||||.||.|||:||||||||.:||.:|||||||||.||||||||:|||||:|||
 Worm   316 VVSRAMTMEINEGRGVGPNKDHIYLQLHHLPAEQLQQRLPGISETAQIFAGVDVTKEPIPVIPTV 380

  Fly   404 HYNMGGVPTNYRGQVITIDKDGKDVIVPGLYAAGEAASSSVHGANRLGANSLLDLVVFGRACAKT 468
            |||||||||||:|||:....:|.|.::||||||||.|:.|||||||||||||||||:|||:||.|
 Worm   381 HYNMGGVPTNYKGQVLDFTPEGGDKVIPGLYAAGECAAHSVHGANRLGANSLLDLVIFGRSCALT 445

  Fly   469 IAELNKPGAPAPTLKENAGEASVANLDKLRHANGQITTADLRLKMQKTMQHHAAVFRDGPILQDG 533
            |...||||...|.|..|..|.|..||:.|.|:.|.|::.:||.|||.|||.||||||.|.:|::|
 Worm   446 ILNENKPGDSIPELPVNCEEKSCDNLNGLLHSKGDISSIELRQKMQMTMQKHAAVFRRGDLLKEG 510

  Fly   534 VNKMKEIYKQFKDIKV-VDRSLIWNSDLVETLELQNLLANAQMTIVSAEARKESRGAHAREDFKV 597
            |:||..|||:.:::|. .|...:|||:|||||||||||.||..|||:||.|.||||||||:||:.
 Worm   511 VDKMSSIYKEQQNLKACADSGKVWNSELVETLELQNLLINANQTIVAAENRTESRGAHARDDFQE 575

  Fly   598 REDEYDFSKPLDGQQKKPMDQHWRKHTLSWVCNDNGDITLDYRNVIDTTLD-NEVSTVPPAIRSY 661
            |.||||:|.||:||||||.|||||||::..:....|.:.|.||.|||.||| :|...|||.:|||
 Worm   576 RIDEYDYSNPLEGQQKKPFDQHWRKHSIIGIDTKTGAVDLTYRPVIDKTLDKSETDWVPPKVRSY 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SdhA	NP_477210.1	PTZ00139	49..661	CDD:240286	440/613 (72%)
		NADB_Rossmann	80..469	CDD:304358	310/388 (80%)
		Succ_DH_flav_C	511..661	CDD:280980	91/151 (60%)
sdha-2	NP_492798.1	PTZ00139	5..640	CDD:240286	448/646 (69%)
		NADB_Rossmann	59..472	CDD:304358	321/412 (78%)
		Succ_DH_flav_C	488..640	CDD:280980	91/151 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161302
Domainoid	1	1.000	685	1.000	Domainoid score	I59
eggNOG	1	0.900	-	-		E1_COG1053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3073
Inparanoid	1	1.050	948	1.000	Inparanoid score	I167
Isobase	1	0.950	-	0.957091	Normalized mean entropy	S148
OMA	1	1.010	-	-		QHG60640
OrthoDB	1	1.010	-	-		D171709at33208
OrthoFinder	1	1.000	-	-		FOG0002411
OrthoInspector	1	1.000	-	-		otm14154
orthoMCL	1	0.900	-	-		OOG6_100447
Panther	1	1.100	-	-	O	PTHR11632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1604
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.760